Meloxicam 7.5mg Treatment of rheumatoid arthritis, osteoarthritis pain (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Meloxicam

Ingredient

Composition information	Content
Meloxicam	7.5mg

Uses

indications

Meloxicam 7.5 mg drug is indicated in the following cases:

rheumatoid arthritis.

Pharmacological

Meloxicam is Oxicam's derivatives of nonsteroidal anti -inflammatory groups with anti -inflammatory, analgesic, fever -reducing properties. Meloxicam has strong anti -inflammatory properties for many types of inflammation, due to the ability to inhibit biosynthesis of prostaglandin, intermediate inflammatory substances. The drug has a selective inhibitory effect on cyclooxygenase - 2 (COX - 2).

Dynamic pharmacokinetics

Meloxicam is well absorbed through the gastrointestinal tract, oral bioavailability reaches 89% compared to intravenous intravenous, very little food affects absorption. About 99% associated with plasma protein.

Good diffuse drugs into joint fluid, concentration in joint fluid is equivalent to 50% of plasma concentrations, free types of drugs in joint fluid is 2.5 times higher in plasma because there is less protein in joint fluid.

Meloxicam is almost completely metabolized in the liver with the main catalyst of CYP2C9 and a small part of CYP3A4. The metabolites are no longer active and excreted mainly through urine and feces. A small amount of drugs without metabolism excreted through urine and feces.

Average half -cancellation time. In humans mitigation or medium function or kidney function (creatinine clearance> 20 ml/ min) does not need to adjust the dose of meloxicam. Meloxicam cannot be separated.

Before taking Meloxicam 7.5mg Treatment of rheumatoid arthritis, osteoarthritis pain (3 blisters x 10 tablets)

How to use

Meloxicam 7.5 mg oral medication.

Patriarchal background at meals.

Dosage

Adults:

Osteoarthritis: Using a dose of 7.5 mg/day. If necessary, it may increase to 15 mg/day.

rheumatoid arthritis, joint spondylitis: 15 mg/day. Depending on the response, the therapy can be reduced by 7.5 mg/day.

Maximum daily dose is recommended 15 mg.

Other similarities:

For the elderly for long -term treatment: 7.5 mg/day. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Meloxicam 7.5 mg, you may experience unwanted effects (ADR).

Common: digestive disorders, nausea, vomiting, abdominal pain, constipation, bloating, diarrhea, anemia, itching, skin rash, headache, edema. Uncommon

: Mild increasing transaminase, bilirubin, belching, esophagitis, stomach -duodenal ulcer, potential gastrointestinal bleeding; leukopenia, thrombocytopenia; stomatitis, urticaria; Hypertension, chest drum, flushed face; increase creatinine and blood urea levels; Dizziness, tinnitus and drowsiness.

Rare: colitis, gastrointestinal ulcers, duodenum, hepatitis, gastritis; Increasing skin sensitivity to light, diverse rash, Stevens - Johnson syndrome, Lyell syndrome, bronchial asthma attacks; Neurological fleet, anaphylaxis.

Instructions on how to handle ADR: When the side effects of the drug are encountered, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

PMS-Meloxicam 7.5 mg contraindicated in the following cases:

History of allergies to Meloxlcam, Salicylate or other nonsteroidal anti -inflammatory.

Bronchial asthma, nasal polyps, nerveema or quincke edema, urticaria after taking aspirin or other nonsteroidal anti -inflammatory drugs.

Severe liver failure and severe kidney failure without dialysis.

Progressive peptic ulcer.

Stomach bleeding, brain bleeding.

Pregnant and lactating women.

Be cautious when used

Meloxicam must be very careful in patients with gastrointestinal pathology or being treated with anticoagulant drugs because the drug can cause stomach - duodenal ulcer, causing bleeding. To minimize unwanted effects, the lowest dose should be used in the shortest possible time.

During the use of drugs with abnormalities on the skin, mucosa or signs of ulcer or gastrointestinal bleeding must stop the drug immediately.

Meloxicam inhibits prostaglandin synthesis in the kidneys leading to reduced renal perfusion. Patients who have reduced blood flow to the kidneys or hypoglycemia such as heart failure, nephrotic syndrome, cirrhosis, severe kidney disease, are taking diuretics or are performing large surgery, which need to check the volume of urine and kidney function before using Meloxicam.

Meloxicam can cause a slight increase in transaminase or different liver function assessment parameters. When these parameters rise beyond the normal limit of meaning or prolonged increase, Meloxicam must be stopped.

In patients with cirrhosis but at a stable stage when taking the drug is not careful to reduce the dose.

Elderly patients with poor liver, kidney and heart function should not use Meloxicam.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery, but can cause unwanted effects such as dizziness, drowsiness, so avoid using Meloxicam while participating in these activities.

Pregnancy

Experimental research does not see evidence of Meloxicam's teratogenic evidence. However, Meloxicam is recommended not to be used for pregnant women, especially in the last 3 months of pregnancy for fear of early closed arterioscleros or other complications for the fetus.

breastfeeding period

should not use Meloxicam. If you need to use medication for mothers, you should not breastfeed.

Drug interaction

should not be coordinated:

Meloxicam with other nonsteroidal anti -inflammatory drugs, anticoagulant oral medications, ticlopidin, heparin using systemic sugar, thrombolytic drugs.

Meloxicam: increases blood lithium, increases the toxicity of methotrexate in blood.

The contraceptive device placed in the uterus: Meloxicam can reduce the effectiveness of contraception.

Precautions:

Diuretics with Meloxicam may most likely lead to acute renal failure in dehydration patients.

Meloxicam increases the toxicity on the kidneys of ciclosporin.

Meloxicam reduces the hypotension effect of high blood pressure treatment.

cholestyramin increases the elimination of meloxicam.

Meloxicam can increase bleeding, so bleeding must be monitored when used with warfarin.

Meloxicam reduces the diuretic effect of Furosemid and the thiazid group.

Storage

less than 30 ° C, avoid moisture and light.

Other drugs

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