Menison 4mg Pymepharco Treatment of endocrine disorders, arthritis, collagen disease (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	4mg

Uses

Indications

Dumpalon 4mg is indicated in the following cases:

Inflammatory diseases:

rheumatoid arthritis (including rheumatoid arthritis in children), stiff spine, acute and semi -acute epidemic inflammation, Animal epidemic inflammation of the joints, non -specific epidemicitis, osteoarthritis Incomure , conjunctiva ulcers, keratitis, tuberculosis meningitis, some vascular inflammation, temporal artery inflammation, arterial inflammation, chronic ulcerative colon.

Diseases related to allergies: Seasonal allergic rhinitis, hypersensitivity to drugs, serum, bronchial asthma and severe allergens including anaphylaxis.

Immune -related diseases: lupus erythematosus Body, heart low.

Raw primary renal disease syndrome, primary or secondary adrenal insufficiency, congenital adrenal hyperplasia, pus -festering thyroiditis, hypercalcemia in cancer.

In cancer treatment: Acute leukemia disease, lymphoma, breast cancer and prostate cancer.

In blood diseases: Anemia hemolysis, granulocytosis.

Sarcoid disease.

Pharmacology

methylprednisolon is a glucocorticoid, 6-alpha-methyl derivative of prednisolon, anti-inflammatory, anti-allergic and immunosuppressive effects.

Anti -inflammatory effects of methylprednisolon increases 20% compared to the effect of prednisolon.

Glucocorticoid uses systemic sugar to increase the number of neutrophils and reduce the number of lymphocytes, eosin leukocytes, multi -core leukocytes in peripheral blood.

Glucocorticoid also inhibits the function of lymphocytes and tissue macrophages. Their response ability with antigens and split substances decreases.

Glucocorticoid also affects inflammatory reaction by reducing prostaglandin synthesis.

Glucocorticoid reduces capillary permeability due to inhibition of the activity of kinin, bacterial internal toxins and reduces the amount of histamine released by base leukocytes.

Dynamic pharmacokinetics

absorption: Methylprednisolon quickly absorbs and plasma concentrations reach a maximum of 1.5 - 2.3 hours after taking the drug. Absolutely highly available about 82 - 89%.

Distribution: Methylprednisolon is widely distributed throughout the tissue, through the brain blood barrier, and excreted into breast milk. The indicator distribution is approximately 1.4 liters/kg. Plasma protein attachment is about 77%.

Metabolic: Metabolic mainly in the liver, partly in the kidneys and then excreted through urine. Methylprednisolon is metabolized in the liver into non-active metabolites mainly 20α-hydroxymethylprednisolon and 20β-hydroxymethylprednisolon. The metabolism in the liver occurs mainly by CYP3A4 enzyme. Like the substrates of CYP3A4, methylprednisolon may be the substrate of p-glycoprotein, which can affect the distribution of tissue and interact with other drugs.

Elimination: The average selling time is about 1.8 -5.2 hours. The total clearance is about 5 - 6 ml/min/kg. No need to adjust the dose in patients with renal failure. Methylprednisolon can be eliminated through hemorrhage.

Before taking Menison 4mg Pymepharco Treatment of endocrine disorders, arthritis, collagen disease (3 blisters x 10 tablets)

How to use

oral Mupison 4mg.

Dosage

Starting dose 4 - 48 mg/day. Dosage should be maintained and adjusted until the response is satisfied. If the treatment for a long time should determine the lowest dose that can achieve the need for gradually reducing the dose until the signs or symptoms increase.

Treatment of acute asthma attacks: 32 - 48 mg/day, used for 5 days, then additional treatment can be added at a lower dosage in a week. When from acute attacks, methylprednisolon is quickly reduced.

Severe diseases: The starting dose is 0.8 mg/kg/day divided into a small dose, then reinforced treatment for a single daily dose, followed by gradually decreasing to the minimum dosage.

Rheumatoid arthritis: The starting dose is 4 - 6 mg/day. During the acute phase, higher doses are 16 - 32 mg/day, then gradually decreases.

Chronic arthritis in children with life-threatening complications: Sometimes methylprednisolon is sometimes used in attacking therapy, at a dose of 10-30 mg/kg/batch (usually used 3 times).

Chronic ulcerative ulcer: severe exacerbations, taking 8 - 24 mg/day.

Nephrotic syndrome: The starting dose is 0.8 -1.6 mg/kg/day for 6 weeks, then gradually reduces the dose for 6-8 weeks.

Immune -soluble hemolysis: Take methylprednisolon 64 mg/day, for 3 days. Methylprednisolon must be treated at least 6 - 8 weeks.

Sarcoid disease: Take methylprednisolon 0.8 mg/kg/day. Using maintenance dose is low 8 mg/day.

Exacentality of scattered sclerosis: 160 mg/day, used for 1 week, then reducing the dose to 64 mg/day, used for 1 month.

Do not stop the drug suddenly after a long time of high doses, slowly reduced dose.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

When using too high doses for a long time, increase adrenal gland energy and inhibit the adrenal glands may occur. In these cases, it is necessary to consider to be able to decide properly to suspend or stop using Glucocorticoid.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Menison 4mg you may experience unwanted effects (ADR).

Common, ADR> 1/100

Infection (including increased sensitivity and severity of infection by concealing symptoms and clinical signs).

Metabolic: Cushing syndrome, sodium and water.

Mental: Easy to touch.

Eyes: cataracts.

Cardiovascular: hypertension .

Digestive: stomach ulcers (gastric bleeding and perforation).

Skin: Skin atrophy, Acne .

Systemic: weak muscle, growth retardation. Reduce the process of healing wounds. Reducing potassium.

Unknown frequency

Cheme infection, tuberculosis recurrence. Kaposi’s Sarcoma.

Blood: leukemia

Pituitary gland: Reduce the pituitary function.

Metabolism: metabolic acid infection, reducing glucose intolerance, increasing insulin demand or hypoglycemic drugs for oral blood glucose in diabetes, increasing appetite.

Mental: Mental disorders, easy to touch, change personality, abnormal action.

Neurological: convulsions, increased pressure in the skull, dizziness, headache .

Eyes: Glaucom, protruding eyes.

Cardiovascular: congestive heart failure, heart muscle hernia after myocardial infarction, hypotension, artery blockage.

Digestive: Perforated intestines, gastric hemorrhage, pancreatitis , esophageal ulcer, bloating, abdominal pain, diarrhea, indigestion, nausea.

Skin: Red rash, itching, urticaria, rash, hemorrhage, hemorrhagic spots.

muscle - bone: muscle atrophy, muscle pain, joint pain, osteoporosis, fracture.

Genital disorders: abnormal menstrual periods.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Menison 4mg medicine contraindicated in the following cases:

Patients who are sensitive to drug ingredients.

Be cautious when using

Use cautiously in people with osteoporosis, new people connecting blood vessels, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, caution must be used for the elderly, with the lowest doses and in the shortest possible time.

Do not stop the drug suddenly after a long time of treatment.

The ability to drive and operate machinery

There is no evidence of the effect of the drug on the ability to drive and operate machinery.

Pregnancy

Taking prolonged drugs for the mother can lead to mitigation of the baby's weight. It is necessary to consider benefits that can be achieved compared to the risks that may occur with mother and child.

breastfeeding period

Precautions when used in breastfeeding women.

Drug interaction

methylprednisolon is a cytochrom P450 enzyme induction, and is the substrate of the P450 3A enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketoconol, ketocon, ketocmazepin Rifampicin.

Phenobarbital, Phenytoin, rifampicin and diuretics decreased potassium can reduce the effectiveness of the drug.

Storage

30 oC. Avoid moisture and light.

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