Mesalazine 500mg Savipharm treatment for ulcerative colitis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Mesalazin

Ingredient

Composition information	Content
Mesalazin	500mg

Uses

indications

Savi Mesalazine 500 medicine is indicated in the following cases:

Treatment ulcerative colitis The last to moderate last to medium segment.

Treatment of Sigma colitis.

Treatment of rectal inflammation. The mechanism of action of mesalazine is not fully understood, but seems to have a local effect, not the body effect.

intestinal inflammation is often accompanied by a tissue diffusion reaction including ulcers and invasive cells of lymphocytes, plasma cells, eosinophils, multi -core cells and active cells. The intervention of mesalazine or leukotrien or the prostaglandin metabolism can play an important role in preventing inflammatory reaction mechanism.

Mesalazine prevents the accumulation of Thromboxan B2 and 6-keto-Prostaglandin F1. Both Mesalazine and SAS (sulfasalazin) reversed H2O, chloride secretion and increased Na secretion in colitis caused in the test on the mouse (cobay mouse, cavia porcellus).

SAS and Masalazin are known to inhibit migrants can inhibit migrants through inhibition of lipoxygenase at lower concentrations than the concentration needed to inhibit prostaglandin synthesis. Therefore, it can be said that both SAS and Mesalazine substances are capable of inhibiting both lines through the inhibition of lipoxygenase.

Mesalazine (5-aminosalicylic acid, 5-ASA), is the active and origin of sulfasalazine. Although the action mechanism of 5-ASA is unclear, this mechanism is due to the combination of many factors.

5-ASA has an inflammatory process through the ability to inhibit the synthesis of prostaglandin, interfere with Leukotriene synthesis and of course create leukocytes' migration with the result of wiping free radicals. Regardless of the method of action, 5-ASA appears mainly on the spot instead of the whole body.

pharmacokinetics

absorption:

Mealazine -soluble tablets when taken orally, the drug passes through the stomach intact. The tablet tends to disintegrate about 5 hours after leaving the stomach.

Distribution:

Average agriculture in the plasma of 5-ASA and N-acetyl-5-ASA 'reaches 0.7 mcg and 1.2 mcg/ml, respectively 500mg x 3 times/day.

Metabolism:

5-ASA is metabolized through the acetyl-gland process. Most of the metabolites N Acetyl-5-Amino-Salicylic Acid have a short serum life.

Era:

Kidney excretion both 5-ASA is free and acetylation (N-AC-5-ASA) into the urine. The average rate of found in urine after drinking 5-ASA is estimated at 44%.

Before taking Mesalazine 500mg Savipharm treatment for ulcerative colitis (10 blisters x 10 tablets)

How to use

oral medication. Swallow, do not chew the tablet.

Dosage

Adults:

Acute treatment: 4 g (ie 8 tablets 500 mg/day), divided into 2-3 times.

Maintain treatment: The starting dose should take 1.5 g (ie 3 tablets 500 mg)/day, divided into 2-3 times.

Dosage for each patient, recommended dose is 2 g (ie 4 tablets 500 mg) masalazin/day, divided into several times.

Children:

Acute ulcerative ulcer:

Children from 5 to 15 years old: 15 - 20 mg/kg (maximum 1 g), 3 times/day.

Children from 15 to 18 years old: 1 - 2 g (2 - 4 capsules), 2 times/day or total daily dose may be divided into 3 times.

Treatment of maintenance of ulcerative colitis and Crohn disease:

Children from 5 to 15 years old: 10 mg/kg (maximum 500 mg), 2 times/day.

Children from 15 to 18 years old: 2 g/time, once a day.

Note: Savi Mesalazine 500 is not suitable for children from 2 to under 5 years old.

Special patient group:

Elderly (> 65 years): There is no information on pharmacokinetics suitable for patients aged 65 and over. Should be cautious with the choice for an elderly patient.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? In case of overdose, actively monitor for timely measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Savi Mesalazine, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Body: headache , fatigue, weakness, dizziness, fever.

digestion: diarrhea , nausea, vomiting, abdominal pain, increasing symptoms of colitis, belching, constipation, indigestion. skin: urticaria, rash, itching, acne.

Respiratory: Sore throat, cough.

Rare, ADR

leukopenia, granulocytosis, anemia property, grain leukemia, neutropenia, thrombocytopenia and hematopoietic disorders.

circulatory: myocarditis, pericarditis.

Skin: Sensitive to light.

liver: increased transaminase, hepatitis.

Bone muscle: joint pain, cramps, back pain.

nerve: neuropathy, mainly affecting the foot.

urinary tract: nephritis, nephrotic syndrome.

Endocrine and metabolism: Increase triglycerides.

Other reactions: hair loss, pancreatitis , masalazin intolerance syndrome.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Savi Mesalazine 500 drug contraindicated in the following cases:

History of hypersensitivity to salicylate or kidneys sensitive to sulfasalazin.

Severe renal failure and liver dysfunction.

Pyloric stenosis, intestinal obstruction.

Children under 2 years old.

Be cautious when using

should be careful if using Mesalazine for patients with impaired liver function, or renal failure.

There has been a serious hematopathy when using masalazin but very rare.

Mesalazine can be used in most hypersensitivity patients or allergies to sulfasalazin. However, be cautious when treating patients allergic to sulfasalazin (risk of allergies to salicylate).

Need to monitor hematology, if the patient has unexplained bleeding, bruises, hemorrhage, anemia, fever or sore throat.

This drug is not recommended in patients with renal failure. Nephrotic function should be regularly monitored as serum creatinine quantification, especially in the early stages of treatment. It is possible to suspect toxicity for the kidneys due to mesalazine in patients with abnormal kidney function during treatment.

Myocarditis and pericarditis caused by Mesalazine have been recorded in rare cases. Must stop treatment when suspected of these unwanted effects.

The ability to drive and operate machinery

is almost no effect. Serious effects on the ability to drive and operate machinery when using Mesalazine has not been reported.

Pregnancy

Precautions when used for pregnant women and only use only when benefits are more than possible. There is a small amount of drugs passing through the placenta.

The period of breastfeeding

Precautions during breastfeeding and only use when benefits are more than possible.

Drug interaction

Timeless with oral sulfasalazin can increase the risk of toxicity to the kidneys.

There has been a notice of increasing prothrombin time in patients using warfarin.

Storage

In the dry place, the temperature does not exceed 30 ° C. Avoid light.

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