Metafeyna 20mg polera medicine for angina treatment (2 blisters x 30 tablets)

Dosage form Box of 2 blisters x 30 tablets
Specifications Trimetazidine

Ingredient

Composition informationContent
Trimetazidine20mg

Uses

Indications

Metafeyna 20 drugs are indicated in cases for adults designated as supplementary/supported therapy in existing treatments to treat symptoms in stable angina patients not fully controlled or non -tolerant patients with other angina treatment therapy.

Pharmacokology

Mechanism of action

By conserving energy metabolism in cells deficient in oxygen or ischemia, trimetazidine prevents ATP decline in cells. Therefore, it still ensures ionic pumping and sodium-potassium flow in the cell membrane while maintaining the lip balance of the cell.

Trimetazidin inhibits beta oxidation of fatty acids by inhibiting 3-ketoacyl-coa thiolase enzymes, promoting glucose oxidation. In ischemic cells, energy during oxidation of glucose consumes less oxygen than the beta oxidation. Glucose oxidation helps optimize cell energy, thus maintaining appropriate energy metabolism during anemia.

Pharmacological effect:

In patients with local heart anemia, trimetazidine acts as a metabolite, which helps conserve high intracellular energy levels in myocardial cell. Trimetazidin has anti -anemia effects but does not affect hemodynamics.

pharmacokinetic

absorption

After drinking, trimetazidin is quickly absorbed from the digestive tract. Birth of over 85%. The peak concentration of serum (TMAX) of trimetazidin appears from 2 to 3 hours after drinking. The concentration of drugs in plasma is stable from 24 to 36 hours after the recommended dose.

Distribution

The peak concentration (CMAX) of trimetazidine after using the single dose (20 mg) is up to approximately 55 ng/ml. Trimetazidine binds to a mild plasma protein (about 16%). The distribution volume is 4.8 l/kg. This shows that the drug is well penetrated into the tissues.

Elimination

Trimetazidin is excreted mainly into urine in the form of non -metabolic drugs. The waste sale time (T1/2) is 6 hours.

Before taking Metafeyna 20mg polera medicine for angina treatment (2 blisters x 30 tablets)

How to use

Oral drugs, meals with meals.

Dosage

Common dose: 1 tablet 20 mg x 3 times/day.

Special subjects

Patients with renal failure

Patients with average renal failure (Creatinin clearance 30 - 60 ml/minute): Dosage recommended is 1 tablet of 20 mg x 2 times/day, with breakfast and dinner.

Elderly patients

Elderly patients may have a higher level of trimetazidine sensitivity than normal due to impaired renal function by age. Caution should be careful when calculating the dose for elderly patients.

Children

Safety and effectiveness of trimetazidin for patients under 18 years of age has not been evaluated. There is currently no data on this patient object.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose?

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Metafyyna 20, you may experience unwanted effects (ADR).

Overall, the drug is well tolerated. Symptoms in the stomach are usually mild (such as nausea, vomiting), headache, chest drums, hypersensitivity reactions (such as skin rash, urticaria) may occur but rare.

Agency group

Frequency

Expression

Common

Dizziness, headache.

Unknown

Parkinson symptoms (Run, slow movement and difficulty, muscle tone), unstable go, restless leg syndrome, other relevant movement disorders, can often recover after stopping the drug

Unknown

Sleep disorders (insomnia, drowsiness)

Rare

Brushing chest drums, suspense, extra mind, fast heartbeat.

Rare

Aortic hypotension, hypotension, which can lead to discomfort, dizziness or falling, especially in patients being treated with anti -hypertension drugs, flushing

Common

Abdominal pain, diarrhea, indigestion, nausea

Unknown

Constipation

Common

Rashes, urticaria.

Unknown

Excavity of the acne pustules (AGEP), Evaluation

Common

weakness

Unknown

Loss of granulocytes.

platelet reduction.

Platelet hemorrhage.

Unknown

Hepatitis

Notify the doctor the unwanted effects occur during the use of the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

MetazyDYNA 20 drugs contraindicated in the following cases:

  • Hypersensitivity to trimetazidin or any ingredients of the drug.
  • Parkinson patient, Parkinson's symptoms, tremor, restless leg syndrome and other relevant movement disorders.

    • Severe renal failure (Creatinine clearance

    Caution when using

    No trimetazidine prescription for cases of patients with dizziness, tinnitus, visual disorders. Patients who are using trimetazidin to treat these symptoms need to talk to the doctor to choose alternative drugs.

    No trimetazidine prescription for Parkinson patients or with Parkinson's similar symptoms, hands tremor, restless leg syndrome or other manifestations related to movement disorders, and not prescribing patients with severe renal impairment.

    Be careful when prescribing trimetazidin for patients with average renal impairment and elderly patients, may consider reducing the dose in this patient.

    It is advisable to stop using trimetazidine for patients with progressive movement disorders such as Parkinson's syndrome. If Parkinson's syndrome lasts more than four months after stopping the drug, consulting the advice of a neurologist.

    Trimetazidin is not suitable for the treatment of acute angina or treatment for patients with unstable angina or myocardial infarction.

    trimetazidin is not used before hospitalization and the first days of hospitalization. While acute angina, coronary ventilation should be considered and changes in treatment (medical treatment is capable of regenerating circuit).

    may experience ego, unsteady or hypotension, especially in patients who are taking drugs to treat hypertension.

    Medications containing red cochineal, which can cause allergic reactions.

    The ability to drive and operate machinery

    No report.

    Pregnancy

    There is no monster birth when using trimetazidin is observed in studies conducted on animals, but adequate and controlled studies have not been conducted in pregnant women. Therefore, it is unclear whether the drug can cause defects for the fetus or not, do not use trimetazidin for pregnant women.

    Breastfeeding period

    There is no study of trimetazidin ability to excrete in breast milk, so do not use trimetazidin for nursing women.

    Drug interaction

    There is no report on trimetazidin interaction with other drugs.

    Storage

    Store at a temperature of less than 30 ° C, in a closed packaging, to dry in a cool place, avoid light.

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