Methotrexate Belmed 2.5mg Psoriasis, Psoriasis, Psoriasis Arthritis, Rheumatoid Arthritis (20 Tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Methotrexate

Ingredient

Composition information	Content
Methotrexate	2.5mg

Uses

Indications

Methotrexate Belmed drug prescribed to treat psoriasis, psoriasis arthritis, rheumatoid arthritis, mushroom warts (T -limb tumor T).

Pharmacokology

Pharmacological group: Anti -cancer drug, metabolic resistance group.

Code ATC: L01BA01

Anti -metabolic drug groups of substances have the same structure similar to folic acid. The drug has anti -cancer effect (cell restraint), immunosuppressive. Methotrexate inhibits dihydrofolate reductase (DHFR), which has the effect of converting dihydroflic acid into tetrahydrofolic acid as the substance involved as a co -factor for the carbon for a nucleotid purine and thymidilate biosynthesis, which is essential for DNA biosynthesis.In addition, in the cell, methotrexate is converted into polyglutamats that have the effect of inhibiting not only dher but also folat-dependent enzymes, including thymidilat synthetase, 5-amino-imidazol-4-carboxamidoriTotid (AICAR) Transamylase.

DNA biosynthesis and repair, cellular cockroaches, at a lower level, it affects RNA and protein biosynthesis. SPECIAL ACCESSORIES SPECIAL, active with tissues with strong cell proliferation, inhibiting the growth of malignant tumors. The fast division cells of the tumor, as well as the bone marrow, fetal cells, oral, intestinal epithelium, bladder are the most sensitive cells with methotrexa.

pharmacokinetics

Goodly absorbed drugs through oral, when taking low doses. When using high doses may not absorb completely. Maximum concentration in serum 1-2 hours after drinking. There is a major change in the drug concentration between patients and each patient, especially when used to repeat.

Maximum absorption after taking the dose exceeds 30 mg/m2 of the skin. About 50% of the absorption drug is attached - inversely with plasma proteins. Methotrexate is easy to diffuse into tissues, with the highest concentration in
liver and kidney; The drug also diffused into the cerebrospinal fluid.

The drug is removed from plasma after 3 -phase elimination. The majority of drugs excreted through pepper within 24 hours. The half -life of methotrexate prolonged in people with renal failure may cause accumulation and poisoning without appropriate dose adjustment.

Before taking Methotrexate Belmed 2.5mg Psoriasis, Psoriasis, Psoriasis Arthritis, Rheumatoid Arthritis (20 Tablets)

How to use

Methotrexate tablets are used orally, before meals, no chewing.

The treatment time is adjusted with each patient, depending on the chemotherapy program, indication, regimen, response and patient tolerance.

Dosage

Dosage for rheumatoid arthritis

The normal starting dose is 7.5 mg once a week (drinking once), or dividing the dose of 2.5 mg separated by 12 hours apart (taken for a total of 3 times per week). To achieve optimal clinical effect, the weekly dose can be increased (maximum of 20 mg), then began to gradually decrease to the lowest dose effectively.

Dosage for psoriasis

The initial oral dose is 10 - 25 mg once a week or 2.5 mg with the time between the drug use is 12 hours, 3 times per week to achieve adequate clinical effect, but not exceed 30 mg/week. The dose is usually increased slowly, after the optimal clinical effect is optimized, the lowest dose is effective.

With mushroom warts

Take 2.5 - 10 mg daily for several weeks or months. Reducing the dose or stopping the drug depends on the response of the patient and the hematology indicators.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? There is no need for special measures to overdose.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using methotrexate belmed often has unwanted effects (ADR) such as:

The most common is nausea, increased liver enzyme in plasma.

Common, ADR> 1/100

Systemic: headache, dizziness. 1/100

Blood: Nasal bleeding, leukopenia, thrombocytopenia.

Skin: itching.

Body: impotence.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Methotrexate Belmed contraindications in the following cases:

Severe renal failure.

Be cautious when using

should avoid conception during and after treatment with methotrexate (at least for men: 2 months after treatment, women: an ovulation cycle). Recommendation of using calcium folinat to reduce the toxicity of the dose of
high after methotrexate treatment.

For patients with marrow, liver failure or renal failure, methotrexat must be used very carefully. This drug must also be used cautiously in alcoholics, or people with gastrointestinal ulcers, and in the elderly or young children. So regularly the liver, kidney and blood function.

In patients using low -doses of methotrexate to treat psoriasis or rheumatoid arthritis, the liver, kidney and blood function must be tested before stable treatment, and then every 2 to 3 months.

To avoid drugs when renal failure is noticeable and stop the drug if the liver function is detected.

Patients and caregivers must report all symptoms and heads that suggest that infections, especially sore throat or if they have shortness of breath or cough.

Use drugs for women during pregnancy and lactation

anti -contraindications during pregnancy (causing fetal death or genetic defects). No breastfeeding when treated.

Pediatric use: Safety and effectiveness in children have not been determined firmly, in addition to cancer chemotherapy.

The effect of drugs on driving and operating machinery

Considering the danger of unwanted effects such as dizziness, confusion, sleeping chicken, while using methotrexate recommends limiting driving and operating machinery.

Drug interaction

Simultaneously with NSAID, Barbiturat, Sulfanilamid, Corticosteroids, Tetracyclin, Trimethoprim, Chloramphenicol, Para-Aminobenzoic and para-aminahovippuric acid, Probenecid increases and prolongs the effects of methottrexate. Folic acid and its derivatives reduce the effect of the drug. Methotrexate increases the effects of indirect anticoagulants (Coumarin or indandion derivatives) and increases the risk of bleeding. The drugs of the penicillin group reduce the clearance of methotrexate.

In case of simultaneous use of methotrexate and asparaginas, methotrexate may lose its effect.

Neomycin (oral) may reduce the absorption of methotrexate (oral). The drugs that cause medical changes in blood will increase leukopenia and/or platelets, if they have the same effect on bone marrow like methotrexate. The function of inhibitors of the bone marrow or radiation therapy will increase the effects of methotrexate and increase the inhibition of bone marrow function.

Conductive toxic effects can be encountered when coordinated with cytarabin. If combined with the vaccine, increase the unwanted effects of the vaccine and reduce the production of antibodies to respond to both live and inactivated vaccines.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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