Methylcobalamin Capsules 1500mcg Softgel Treatment of peripheral neuropathy (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylcobalamin

Ingredient

Composition information	Content
Methylcobalamin	1500mcg

Uses

indications

Methylcobalamin is indicated in the following cases:

Treatment of peripheral neuropathy.

Pharmacology

mecobalamin is a form of coenzyme of vitamin B12 in the blood and cerebrospinal fluid. This active ingredient is transported into a neurological tissue higher than other types of vitamin B12. According to the biochemical mechanism, mecobalamine enhances the metabolism of nucleic acid, protein and lipid through methyl group transfer reactions. Pharmacological, Mecobalamin has the effect of restoring damaged nerves and preventing abnormal nerve impulses. Mecobalamin promotes the maturity and division of Red blood cells, synthesized heme, thus treating anemia.

Pharmacokinetics

absorption

After drinking, mecobalamin is absorbed through the intestine, mainly in the ileum in two mechanisms: passive mechanism when used in large amounts and positive mechanisms when used at the level of treatment. The absorption of mecobalamin is supported from the intrinsic factor, glycoprotein, which is secreted by the cell into the stomach mucosa.

Distribution

Natural vitamin B12 is found through the process of separation from the protein in the stomach thanks to the activity of acid and pepsin. The derivatives of the B12 produced in this process are mecobalamin and adenosylcobalamin. All the derivatives of the B12 bind to a protein called Haptocorrin or R protein, which is secreted by salivary glands and gastric mucosa. The process of creating links takes place in the stomach. The pancreatic protease partially reduces the cobalamin - Haptocorrin complex in the small intestine - where the cobalamin is released and then linked to the intrinsic factor (IF). Cobalamin complexes - internal factors are absorbed at the end of the intestine. Cobalamin is released from the cobalamin complex - internal factor, then linked to another protein called Transcobalamin and is put into the circulatory system.

Metabolism

In the liver, Cobalamin is partially metabolized, the rest is transported to other tissues of the body through the circulatory system. The cobalamin complex - transcobalamin is metabolized in cells through the lysosom protease to create metabolites: cyanocobalamin, mecobalamin, adenosylcobalamin, hydroxocobalamin. Cobalamin is transformed to form mecobalamin in the cytoplasm and create adenosylcobalamin in mitochondria. Mecobalamin is the main circulation of cobalamin in the body.

mecobalamin binds to 3 types of plasma transport proteins, transmecobalamin 1 (TCI), Transmecobalamin 2 (TCII), Transmecobalamin 3 (TCIII).

Elimination

mecobalamin is excreted through bile and urine. The excretion through bile is reabsorbed in the intestine.

Before taking Methylcobalamin Capsules 1500mcg Softgel Treatment of peripheral neuropathy (3 blisters x 10 tablets)

How to use

Used by oral, can be taken with or without food.

Dosage

The usual dose for adults is taking 1 tablet/day (1500μg of mecobalamin).

Dosage should be adjusted depending on the age of the patient and the severity of the symptoms.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

How to handle

If an overdose occurs, it is necessary to treat symptoms. In the case of hydroxocobalamin is the main cause of toxicity, which is required to be dialysis for the patient. Actively monitor for timely handling measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using methylcobalamin, you may experience unwanted effects (ADR).

Uncommon, 1/1000

Neurological: headache.

Digestive: reducing appetite, nausea/vomiting and diarrhea.

Skin and subcutaneous tissue: rash.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Methylcobalamin is contraindicated in the following cases: Patients with a history of hypersensitivity to mecobalamin or any excipients.

Be cautious when using

Do not take the drug for too long if you do not see the response after the treatment period.

The ability to drive and operate machinery

There is no drug report that affects the ability to drive and operate machinery.

Pregnancy

There is no full study of Mecobalamin use in pregnant women. However, vitamin B12 or precursors should be supplemented during pregnancy.

The period of breastfeeding

has not set data safely, only used when the treatment benefits are higher than any risk that may occur.

Drug interaction

When using mecobalamin along with chloramphenicol (with greater concentrations or 25 mcg/ml) can cause bone marrow syndrome, due to chloramphenicol that can resist the blood creation effects of mecobalamine. Therefore, the patient's response should be monitored when combining the drug and changing other antibiotics if possible.

Storage

Store at room temperature not more than 30 ° C, avoid light and avoid moisture after opening the lid.

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