Methyldopa 250mg Traphaco tablets for hypertension (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Methyldopa

Ingredient

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Composition information	Content
Methyldopa	250mg

Uses

Indications

Methyldopa drug indicated in the following cases:

Methyldopa is used to treat hypertension. Methyldopa can also be combined with beta blockers. The anti -hypertension effect of methyldopa is probably because the drug is metabolized in the central nervous system to A - Methyl Norepinephrin, which stimulates the receptors of the A -adrenergic body leading to a decrease in sympathetic tone and reducing blood pressure. Therefore, Methyldopa is considered a sympathetic drug that has a central impact.

Methyldopa also reduces the lyin activity in plasma and contributes to the hypotension effect of the drug. Methyldopa has been shown to reduce the concentration of serotonin, dopamine, norepinephrin and epinephrin in tissues.

Methyldopa lowers blood pressure both in a standing position and a lying position. The drug does not directly affect the kidney and heart function. Cardiac supply is usually maintained; No heart frequency increases. In some cases, it can be seen that the heart rate slows down. The supply of kidney, glomerular filtration, or filter fraction is often not affected, so the effect of reducing blood pressure can be maintained even in patients with renal impairment.

pharmacokinetics

The absorption of methyldopa is incomplete. The average bioavailability only reaches 25% of the dose, and changes a lot among patients.

The maximum concentration in plasma is achieved within 2-4 hours after drinking, the anti -hypertension effect is maximum after 4 - 6 hours. The half -life in the plasma of the drug is 1-2 hours for people with normal renal function and increases when the kidney function decreases.

About 70% of the dose is excreted through the kidneys, of which 60% are free methyldopa, the rest is metabolites in the form of a conjugate form.

Before taking Methyldopa 250mg Traphaco tablets for hypertension (10 blisters x 10 tablets)

How to use

Drug tablets for oral film.

Dosage

Adults

Starting dose: 250 mg/time, 2-3 times/day, used in the first 2 days.

Then adjust the dose depending on the response of each patient (the distance between two adjustments at least 2 days). To minimize the sedative effect, should start increasing the dose in the evening.

Maintain treatment: usually 0.5 - 2 g/day, divided 2-4 times. Do not use more than 3 g/day.

Should be used in combination with thiazid diuretics if not started with thiazid or if the effect of reducing blood pressure does not reach a dose of 2 g/day.

Elderly

Starting dose 125 mg/time, 2 times/day, the dose may increase gradually. Maximum dose of 2g/day.

Children

The starting dose is 10 mg/kg body weight/day, divided into 2-4 times. The maximum dose is 65 mg/kg or 3 g/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose treatment: Symptomatic treatment and support, may be gastrointestinal or vomiting. If the drug has been absorbed, it can be transmitted to increase the elimination of the drug through the urine. Special attention should be paid to heart frequency, blood flow, electrolyte balance, intestinal paralysis and brain activity.

Can use drugs that are similar to sympathetic effects such as Levarterenol, Epinephrin, Metaraminol.

methyldopa can be excluded from circulation by hemorrhage.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using methyldopa often has unwanted effects (ADR) such as:

Systemic: dizziness, fatigue, fever, may have a headache when newly treated (after all), weakness (rarely).

Central nervous system: The most common is sedative and drowsiness. Reduce intelligence, paresthesia (rarely). Rarely encounter face paralysis, incontinence dance movement, cerebral disabled syndrome, Parkinson's symptoms.

Digestive system: may dry mouth, nausea, vomiting, diarrhea. Rarely encounter pancreatitis, colitis, salivary gland inflammation, black tongue, flatulence.

cardiovascular system: can cause edema, lower posture hypotension, hypotension when standing. Rarely slow heart rate, worsen angina, heart failure, sinus impairment syndrome, myocarditis, pericarditis, diseases like lupus erythematosus.

Blood and immunity: It can be positive for a positive Coombs when treatment lasts but rarely becomes hemolytic anemia. Rarely suffer from bone marrow failure, leukemia, granulocytosis, thrombocytopenia, hemolytic anemia, huge red blood cell anemia. If hemolytic anemia occurs with a positive COOMB reaction (usually after 6-12 months of treatment), the drug should be stopped.

Endocrine: can reduce sex, rare menstruation, big breasts in men, increase milk secretion.

Respiratory: may have a stuffy nose.

Other effects: rarely occur skin rash, epidermal necrosis, arthritis or muscle pain, depression, jaundice, hepatitis.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Methyldopa drugs are contraindicated in the following cases:

Hypersensitivity to the drug.

Precautions when using

methyldopa should be used carefully in the following cases:

History of liver disease or anti -liver dysfunction; severe renal failure; History of hemolytic anemia; Parkinson's disease; Mental depression; Porphyrin metabolism disorders; Atherosclerosis.

should periodically test the blood formula and test the liver for the first 6-12 weeks of treatment or when the fever is unknown.

The effect of the drug on the ability to drive and operate machinery

methyldopa can cause drowsiness, should not drive or operate machinery when taking the drug.

Use drugs for women during pregnancy and lactation

pregnancy

Unknown about drug risks. Methyldopa can be used for hypertension caused by pregnancy. However, only medication for pregnant women on the basis of careful evaluation of beneficial aspects.

Breastfeeding period

methyldopa is excreted into breast milk, which can cause risks for children with the dose of treatment commonly used for nursing mothers. So the drug should not be used for breastfeeding.

Drug interaction

should be cautious when used simultaneously with the following drugs:

Other drugs for hypertension: The drug may increase the effect of lowering blood pressure, increasing adverse reactions.

Anesthesia: Must reduce the dose of anesthetic; If hypotension during anesthesia can take vasoconstrictor drugs.

Lithi: The drug increases the toxicity of lithium.

Monoamine inhibitors (Mao): Excessive hypotension.

Amphetamine, central nerve stimulants, 3 -round antidepressants: causing antagonism to treat hypertension and loss of blood pressure control.

iron hematopsius has: Methyldopa's concentration in plasma and reducing anti -hypertension effects of methyldopa.

Oral contraceptives: increases the risk of vascular damage and makes it difficult to control blood pressure.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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