Methyloston 16 Boston anti -inflammatory Boston, treat adrenal insufficiency, arthritis, lupus erythematosus (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Methylprednisone

Ingredient

Composition information	Content
Methylprednisone	16mg

Uses

Indications

Methylboston 16 mg is indicated in the following cases:

Endocrine disorders: primary and secondary adrenal insufficiency, congenital adrenal hyperplasia. PEMPHIGUS Normal. Symids, tuberculosis (when using appropriate tuberculosis chemotherapy), Inhalation pneumonia. TB meninges (when using appropriate tuberculosis chemotherapy), organs.

Pharmacokinetics

absorption

methylprednisolone acetate is hydrolyzed into a form of serum cholinesterase. In humans, methylprednisolone establishes weak complexes that are easy to separate with albumin and transcortin.

Distribution

about 40 - 90% of the drug is connected to plasma proteins. The internal impact of glucocorticoid cells gives a clear difference between the semi -cancellation time and the semi -pharmacological time according to pharmacological.

The extension of the anti -inflammatory activity of glucocorticoids is similar to the time of reducing the activity of the hypothalamus shaft - pituitary - adrenal (HPA).

Metabolism

Metabrednisolone metabolism in the liver is similar in terms of qualitative to cortisol. The main metabolites are 20-Beta Hydroxymethylprednisolone and 20-Beta-Hydroxy-6-Alpha-Methylprednisolone.

Elimination

Metabolic substances are mainly excreted in urine in the form of glucuronide, sulfate and unnecessary compounds. These complex reactions occur mainly in the liver and may be in the kidneys for a few levels.

Before taking Methyloston 16 Boston anti -inflammatory Boston, treat adrenal insufficiency, arthritis, lupus erythematosus (3 blisters x 10 tablets)

How to use

Methylboston 16 mg oral.

Dosage

Indication

Recommended dose

Maximum of 64 mg of a single dose/Daily treatment with a dose of 100 mg

12 - 16 mg

8 - 12 mg

16 - 100 mg

Average level

4 - 8 mg

16 - 100 mg

Children

4 - 8 mg

16 - 60 mg

48 mg

Maximum 48 mg per day during acute phase

20 - 100 mg

Maximum of 3.6 mg/kg/day

low heart

48 mg until normal blood deposit rate in 1 week

Low muscle pain

64 mg

allergies

12 - 40 mg

32 - 48 mg Daily treatment

eye disease

12 - 40 mg

1 - 360 mg

The starting dose may vary vary depending on the condition that is needed. Must continue treatment until clinical response. If not met with 7 days, it is necessary to reassess to confirm the initial diagnosis. In the case of clinical response, daily dosage should be gradually reduced or stopped treatment in case of acute diseases (such as seasonal asthma, flaky dermatitis, acute eye inflammation) or minimum maintenance dose in case of chronic diseases (such as rheumatoid arthritis, systemic lupus erythema, brave asthma, atopic dermatitis).

Treatment for daily is a corticosteroid dosage in which the patient takes 2 times the daily dose of corticosteroids every 8 am of the first day and does not take the drug on the second day and then repeat.

Elderly

In case of treatment for the elderly, especially if long -term treatment should be cautious because the common side effects of corticosteroids may be more serious in this object, especially osteoporosis, diabetes, hypertension, sensitivity to infection and skin thinning.

Children

Dosage for children must be based on clinical response and doctor's decision. The treatment should be limited to the minimum dosage in the shortest time. If possible, single dose and daily treatment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? When using too high doses for a long time, it may increase the adrenal gland energy and inhibit the adrenal glands.

In these cases, it is necessary to consider to make the right decision to suspend or stop using the drug.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using methylboston 16mg, you may experience unwanted effects (ADR).

The most common effects occur most when using methylprednisolone high doses and long -term.

methylprednisolone inhibits prostaglandin synthesis and thus losing the effect of prostaglandin on the gastrointestinal tract, including inhibiting gastric acid secretion and protecting the stomach lining.

Common

Central nerve: Insomnia, nervousness is easily agitated.

digestion: Increase appetite, indigestion. Skin: Skin.

Endocrine and metabolism: diabetes.

Neurosomal and bone: joint pain.

Eyes: cataracts, glaucoma.

Respiratory: Nosebleeds.

Less

Central nerve: dizziness, convulsions, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension. skin: acne, skin atrophy, bruising, tissue hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, pituitary inhibition, adrenal, slow growth, glucose intolerance, hypokalemia, alkaline infection, amenorrhea, sodium and water, hyperlem of blood glucose.

digestion: stomach ulcers, nausea, vomiting, bloating, esophageal ulcer, pancreatitis.

nervous - muscle and bone: muscle weakness, osteoporosis, broken bone.

Other: Hypersensitivity reaction.

Unwanted effects can be reduced by using the lowest dose effectively in the shortest time.

Instructions on how to handle ADR

Notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Methylboston 16 mg is contraindicated in the following cases:

Patients with systemic fungal infections.

Patients with systemic infection unless using specific anti -infections.

Patients with hypersensitivity to methylprednisolon or any ingredient of the drug.

Do not use live vaccines, reduce poison for patients taking corticosteroid immunosupplaces.

Be cautious when using

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stress.

Be cautious in people with osteoporosis, new blood vessels, mental disorders, stomach ulcers, duodenum, diabetes, hypertension, heart failure and growing children.

Use cautiously for the elderly, should be used in the lowest doses and in the shortest possible time.

High -dose corticosteroids can affect the effects of vaccines.

Be cautious when used for train drivers or operating machines, pregnant women and nursing.

The ability to drive and operate machinery

Patients if dizzy or other central neurological disorders, including visual disorders, should not drive and operate machinery.

Pregnancy

Precautions when taking drugs for pregnant women.

breastfeeding period

Be cautious when taking the drug for breastfeeding women.

Drug interaction

methylprednisolone affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconazol, rifampicin.

Phenytoin, Phenobarbital, Rifampicin and diuretics decreased potassium can reduce the effectiveness of methylprednisolone.

methylprednisolone may cause increased blood glucose, so higher insulin dose.

Storage

Keep the drug in a dry place, the temperature does not exceed 300C. Avoid light.

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Disclaimer

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