Methylprednisolon 16 khapharco anti -inflammatory, treat rheumatoid arthritis, systemic lupus system (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	16mg

Uses

indications

Methylprednisolon 16mg is indicated in the following cases:

Treatment of rheumatoid arthritis, systemic lupus erythematosus, some vascular inflammation. paralysis.

Due to methylation Prednisolon, the effect of corticosteroids metabolizes salt has been excluded, so there is very little risk of keeping Na+, and causing edema. The anti -inflammatory effect of methylprednisolon increases by 20% compared to the effect of Prednisolon; 4mg methylprednisolon is valid as 20mg of hydrocortison.

Glucocorticoids inhibit the phenomenon of vascular drainage and permeability of the white blood cells into the tissue (position) of inflammation. Glucocorticoids inhibit these phenomena. Glucocorticoid uses systemic sugar to increase the number of neutrophils and reduce the number of lymphocytes, eosin blood cells, single -glossy leukocytes in peripheral blood.

In addition to the effect on the function of leukemia, glucocorticoid also affects inflammatory reaction by reducing prostaglandin synthesis due to phospholipase activation A. glucocorticoid increases the concentration of some film phospholipids that inhibit prostaglandin synthesis.

corticosteroids also increase lipocortin levels, which is a protein that reduces phospholipid, substrate of phospholipase A. Finally, glucocorticoid reduces the appearance of cyclo-oxygenase in inflammatory cells, thus reducing the amount of enzyme to produce prostaglandin.

Glucocorticoid reduces capillary base due to inhibiting the activity of kinine and bacterial internal toxins and reduces the amount of hydrophilia by base leukemia.

Pharmacokinetics

absorption

bioavailability is approximately 80%.

Distribution

Plasma concentration reaches a maximum of 1-2 hours after taking the drug.

Biological effect time (pituitary inhibitor) is about 15 days, which can be considered a short effect.

Metabolism

methylprednisolon is metabolized in the liver, like metabolism of hydrocortison.

Elimination

The metabolites excreted through the urine. Half life is approximately 3 hours.

Before taking Methylprednisolon 16 khapharco anti -inflammatory, treat rheumatoid arthritis, systemic lupus system (10 blisters x 10 tablets)

How to use

Methylprednisolon 16mg tablets for oral tablets.

Dosage

The normal starting dose is: 6 - 40mg of methylprednisolon per day.

The necessary dose to maintain the desired treatment is lower than the dose needed to achieve the original effect, and must determine the lowest dose possible to achieve the need by reducing the dose gradually until seeing signs or symptoms increased.

When you need to use big doses for a long time, apply medication therapy after day after controlling the process of the disease, there will be fewer side effects because of the recovery time between each dose.

In a daily -way therapy, using a single dose of methylprednisolon every 2 days, in the morning, the span of natural secretion glucocorticoid.

The dose is often used to treat severe asthma attacks for inpatient people:

First, Methylprednisolon intravenous injection 60 - 120 mg/time, every 6 hours of injection, after recovering acute asthma, daily dosage 32 - 48 mg.

The dose is often used to treat acute asthma attacks:

methylprednisolon 38 to 48 mg daily, for 5 days, then additional treatment can be added at a lower dose for a week.

Common doses used to treat low disease:

At first, Methylprednisolon usually used 0.8 mg/kg/day divided into small doses, then reinforced treatment for a single daily dose, followed by a minimum reduced to the minimum dosage.

The dose is often used to treat rheumatoid arthritis:

The starting dose is 4 to 6 mg of methylprednisolon per day.

The dose is often used to treat chronic arthritis in children with life -threatening complications:

Sometimes methylprednisolon is sometimes used in attack therapy, at a dose of 10 to 30 mg/kg/time (usually 3 times).

Common dose used to treat chronic ulcerative ulcer:

Mild illness: Holding (80 mg).

The dose is often used to treat nephropathy syndrome:

Start, use daily methylprednisolon doses of 0.8 to 1.6 mg/kg for 6 weeks, then gradually reduce the dose for 6 to 8 weeks.

The dose is often used to treat immunosuppressive hemolytic anemia:

Take methylprednisolon daily 64 mg, for 3 days.

The common dose is used to treat sarcoid disease:

methylprednisolon 0.8 mg/kg/day, to improve the disease.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

What to do when you forget 1 dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using methyl 16mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: Insomnia, nervousness is easily agitated.

Digestive: Increase appetite, indigestion.

Skin: Hairy.

endocrine and metabolism: diabetes.

Neurosurgery and bone: joint pain.

Eyes: cataract, glaucom.

Respiratory: nosebleeds.

Uncommon, 1/1000

Central nerve: dizziness, convulsions, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension.

Skin: acne, skin atrophy, bruising, tissue hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, Online inhibition of Yen - adrenal, slow growth, glucose intolerance, hypokalemia, alkaline infection, amenorrhea, sodium and water, hyperglycemia.

Digestive: stomach ulcers, nausea, vomiting, bloating, esophageal ulcer, pancreatitis.

Neuros - muscles and bones: muscle weakness, osteoporosis, broken bone.

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

After a long -term treatment with glucocorticoid, inhibiting the exchange - pituitary - adrenal gland is likely to occur, the urgent thing is to reduce the dose of glucocorticoids by step by step, instead of sudden stopping.

Applying the treatment regime to avoid continuous effects of drugs with pharmacological effects. Using a single dose of the day causes less ADR than the doses of division, and the day -by -way therapy is a good measure to minimize the inhibition of adrenal glands and other ADRs. During daily therapy, use a single dose every two days, in the morning.

Monitor and periodically evaluate the parameters of osteoporosis, hemorrhage, glucose tolerance, eye effects and blood pressure.

Preventive gastric and duodenal ulcer prophylaxis with H2 - histamine anti -receptors when using high doses of methylprednisolon.

All long -term patients with glucocorticoid need to use calcium supplements to prevent osteoporosis. People who are likely to be immunosuppressive due to glucocorticoid should be warned about the possibility of infection.

Patients who are about to have surgery may have to use glucocorticoid supplements because of the normal response to stress has been reduced due to the inhibition of hill - pituitary - adrenal glands.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Methylprednisolon 16mg contraindications in the following cases:

Hypersensitivity to methylprednisolon.

Severe bacterial infections (except for bacterial shock and meningitis).

Virus, mushroom or tuberculosis skin lesions.

Using a live virus vaccine.

Caution when using

Use cautiously in people with osteoporosis, new people connecting blood vessels, mental disorders, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when the drug is stopped suddenly after a long time of treatment or when there is stress.

When high doses, can affect the effects of vaccination vaccinations.

Children may be more sensitive to adrenal inhibition when treating topical medication.

The ability to drive and operate machinery

In the treatment dose, Methylprednisolon 16mg does not affect the ability to drive or operate machinery during oral treatment.

Patients should be instructed that if they feel dizzy, headache, they should avoid doing things that are dangerous such as driving or operating machinery

Pregnancy

Prolonged methylprednisolon for mothers can lead to mitigation of babies.

Therefore, using methylprednisolon in pregnant people requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

breastfeeding period

Methylprednisolon 16mg is used for nursing mothers.

Drug interaction

methylprednisolon is a cytochrom P450 enzyme induction, and is the substrate of the P450 3A enzyme, so this drug affects the metabolism of ciclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconol, rifampicine.

Phenytoin, Phenobarbital, Rifampicin, and diuretics decreased potassium can reduce the effectiveness of methylprednisolon.

methylprednisolon may cause hyperlem of blood glucose, so the higher insulin dose is needed. Because there are no studies on the cavalry of the drug, not mixing this drug with other drugs.

Storage

Storage: Under 30 ° C, in a dry place, avoiding light.

Expiry date: 36 months from the date of production.

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