Methylprednisolon 4 Khapharco anti -inflammatory, treat rheumatoid arthritis, systemic lupus system (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	4mg

Uses

Indications

Methylprednisolon 4mg is indicated in the following cases:

Rheumatoid arthritis, systemic lupus, some vascular inflammation. Nguyen Phat.

Due to methylation Prednisolon, the effect of corticosteroids metabolizes salt has been excluded, so there is very little risk of keeping Na+, and causing edema. The anti -inflammatory effect of methylprednisolon increases by 20% compared to the effect of Prednisolon; 4mg methylprednisolon is valid as 20mg of hydrocortison.

Glucocorticoids inhibit the phenomenon of vascular drainage and permeability of the white blood cells into the tissue (position) of inflammation. Glucocorticoids inhibit these phenomena. Glucocorticoid uses systemic sugar to increase the number of neutrophils and reduce the number of lymphocytes, eosin blood cells, single -glossy leukocytes in peripheral blood. Neutral leukocytes increased by an increase in the mobilization of neutral leukocytes from the bone marrow reserves, because their half -life in the blood circulation is prolonged and due to vascular escape and infection into the site of inflammation. The reduction of the number of lymphocytes, eosine leukemia and single -blood cells in the blood circulation is the result of their transportation from blood vessels into lymphoma.

In addition to the effect of leukemia, glucocorticoid also affects inflammatory reaction by reducing prostaglandin synthesis due to phospholipase activation A. glucocorticoid increases the concentration of some film phospholipids that inhibit prostaglandin synthesis. Corticosteroids also increase lipocortin levels, which is a protein that reduces phospholipid, substrate of phospholipase A. Finally, glucocorticoid reduces the appearance of cyclo-oxygenase in inflammatory cells, thus reducing the amount of enzyme to produce prostaglandin.

Glucocorticoid reduces capillary permeability due to inhibition of the activity of kinin and bacterial internal toxins and reduces the amount of hydrophilia by base leukocytes.

pharmacokinetic

bioavailability is approximately 80%.

Plasma concentration reaches a maximum of 1-2 hours after taking the drug.

Biological effect time (pituitary inhibitor) is about 15 days, which can be considered a short effect.

methylprednisolon is metabolized in the liver, like metabolism of hydrocortison, and the metabolites excreted through the urine.

Half life is approximately 3 hours.

Before taking Methylprednisolon 4 Khapharco anti -inflammatory, treat rheumatoid arthritis, systemic lupus system (10 blisters x 10 tablets)

How to use

Methylprednisolon 4 Used orally.

Dosage

Determine the dose for individuals.

The starting dose is: 6 - 40 mg of methylprednisolon per day. The necessary dose to maintain the desired treatment is lower than the dose needed to achieve the initial effect, and must determine the lowest dose that can be achieved by the need for gradually reducing the dose step by step until the signs or symptoms increase.

When you need to take large doses for a long time, apply medication therapy the day after control of the process of the disease, it will be less ADR because there is a recovery time between each dose. During the daily therapy, using a single dose of methylprednisolon every 2 days, in the morning in the span of natural secretion glucocorticoid.

Treatment of severe asthma attacks for inpatient people:

First, Methylprednisolon intravenous injection 60 - 120mg/time, every 6 hours of injection, after recovering acute asthma attacks, taking daily dose 32 - 48mg. Then gradually reduce the dose and may stop taking the drug within 10 days to 2 weeks, from the start of corticosteroid treatment.

Acute asthma attacks:

Methylprednisolon 38 to 48mg daily, for 5 days, then additional treatment can be added at a lower dose for a week. When from acute attacks, methylprednisolon is gradually reduced.

Severe diseases:

At first, Methylprednisolon often used 0.8mg/kg/day divided into a small dose, then reinforced treatment for a single daily dose, followed by a minimum reduction to the minimum dose.

rheumatoid arthritis:

The starting dose is 4 to 6mg of methylprednisolon per day. During exacerbation, higher doses: 16 to 32mg/day, then gradually decreases. Chronic arthritis in children with life -threatening complications: Sometimes methylprednisolon is sometimes used in attacking therapy, at a dose of 10 to 30mg/kg/batch (often used 3 times).

Chronic ulcerative ulcer:

Mild disease: indented (80mg); Execute feature: Take (8 to 24mg/day).

Nephromatic kidney syndrome:

Start, use daily methylprednisolon doses of 0.8 to 1.6mg/kg for 6 weeks, then gradually reduce the dose for 6 to 8 weeks.

Immune hemolytic hemolytic anemia:

Take Methylprednisolon every day 64mg, for 3 days. Methylprednisolon must be treated for at least 6-8 weeks.

Sarcoid disease:

methylprednisolon 0.8mg/kg/day, to improve the disease. Low maintenance dose, 8mg/day.

There is no special requirement on drug treatment after use.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using methylprednisolon 4, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nervous system: Insomnia, nervousness is easily agitated. Orange.

Central nervous system: dizziness, convulsions, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment. Glucose, reduced blood potassium, alkaline infection, amenorrhea, sodium and water, hyperglycemia

In the level indications, Glucocorticoid should be used at the lowest doses and in the shortest time of clinical effect.

After a long -term treatment with glucocorticoid, if the hill -gland -pituitary - adrenal inhibitor inhibits the adrenal gland, it is likely to occur, the urgent thing is to reduce the dose of glucocorticoids step by step, instead of sudden stop.

Applying the treatment regime to avoid continuous effects of drugs with pharmacological effects. Using a single dose of the day causes less ADR than the doses of division, and the day -by -way therapy is a good measure to minimize the inhibition of adrenal glands and other ADRs. In daily therapy, use a single dose every two days, in the morning.

Monitoring and periodic assessment of osteoporosis parameters, hemorrhage, glucose tolerance, eye effects and blood pressure.

Preventive gastric and duodenal ulcer prophylaxis with H2 - histamine anti -receptors when using high doses of methylprednisolon.

All patients with long -term treatment with glucocorticoid need to use calcium supplements to prevent osteoporosis.

People who are likely to be inhibited by glucocorticoids should be warned about the likelihood of infection.

Patients who are about to have surgery may have to use glucocorticoid supplements because of the normal response to stress has been reduced due to the inhibition of hill - pituitary - adrenal glands.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Methylprednisolon 4 contraindications in the following cases:

Hypersensitivity to methylprednisolon.

Precautions when using

Use cautiously in people with osteoporosis, new blood vessel connection, mental disorders, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stressed.

When using high doses, it can affect the effect of vaccination.

Children may be more sensitive to adrenal inhibition when treating topical medication.

The ability to drive and operate machinery

In the treatment dose, Methylprednisolon 4 does not influence the ability to drive or operate machinery during oral treatment.

Patients should be instructed that if they feel dizzy, headache, they should avoid doing things that are dangerous such as driving or operating machinery.

Pregnancy and lactation

Pregnancy

Methylprednisolon for methylprednisolon can lead to mitigation of the babies. Therefore, using methylprednisolon in pregnant people requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

Breastfeeding period

Usable for breastfeeding.

Drug interaction

methylprednisolon is a cytochrom p enzyme induction, and the substrate of the P450 3A enzyme, so this drug affects the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepin, ketoconzol, ketoconon, ketoconon Rifampicin.

Phenytoin, Phenobarbital, Rifampicin, and diuretics decreased potassium can reduce the effectiveness of methylprednisolon.

methylprednisolon may cause hyperlem of blood glucose, so the higher insulin dose is needed. Due to no studies on the correlation of the drug, not mixed with this drug with other drugs.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

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