Methylprednisolone Blue 4mg anti -inflammatory, hormonal disorders (100 tablets)

Dosage form Box of 100 capsules
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	4mg

Uses

Indication

Methylprednisolone Blue 4mg is indicated in the following cases:

Treatment of endocrine disorders

primary and secondary adrenal disabilities: Methylprednisolon can be used but must be combined with a mineralocorticoid such as hydrocortison or cortison. Lesson

Low disorders (joints)

Short -term additional therapy to help patients avoid drama or granted in the following cases:

Rheumatoid arthritis, including rheumatoid arthritis in children.

Stiffness of the vertebrae.

Acute and acute epidemic inflammation.

Courtitis of joints.

Non -specific sophisticated tendonitis.

Osteoarthritis after injury.

Psoriasis arthritis.

Muzzle inflammation on the convex.

Gout arthritis.

Collagen disease:

Maintain or granted treatment in cases

Lupus erythema.

Systemic muscle inflammation. Low heart level.

Skin disease:

pemphigut.

Diverse roses.

seborrheic dermatitis.

Peeling dermatitis.

Psoriasis.

Allergy:

Seasonal allergic rhinitis.

Hypersensitivity to the drug.

Serum disease.

Contact dermatitis.

bronchial asthma.

Allergic dermatitis.

Eye disease:

Allergic conjunctiva ulcer.

eye neuritis.

Mi iris inflammation.

Malaritis.

Respiratory disease:

Inhaled pneumonia.

Sacoid disease.

Beri poisoning.

Leeffler syndrome.

Blood disease:

Anemia hemolysis.

Skills of spontaneous platelets in children.

Secondary platelets in children.

Red blood cells.

congenital anemia.

Tumor disease:

leukemia and lymphoma in children.

Other indications:

Crohn's disease.

Causes the urine or decreased proteinuria in nephrotic syndrome.

Exacerbation of scattered sclerosis (nervous system)

TB meningitis.

Pharmacology

Methylprednisolon is a glucocorticoid, 6-alpha-methyl derivative of Prednisolone, anti-inflammatory, anti-allergic and immunosuppressive effects.

Due to methylation Prednisolon, the effect of corticosteroids metabolizes salt has been excluded, so there is very little risk of keeping Na+, and causing edema. The anti -inflammatory effect of methylprednisolon increases by 20% compared to the effect of Prednisolon; 4mg methylprednisolon is valid as 20mg of hydrocortison.

Glucocorticoids inhibit the phenomenon of vascular drainage and permeability of the white blood cells into the tissue (position) of inflammation. Glucocorticoids inhibit these phenomena. Glucocorticoid uses systemic sugar to increase the number of neutrophils and reduce the number of lymphocytes, eosin leukocytes, single -blood leukocytes in peripheral blood.

In addition to the effect of the leukemia, glucocorticoid also affects inflammatory reaction by reducing prostaglandin synthesis due to phospholipase activation a.

Glucocorticoid increases the concentration of some membrane phospholipids that inhibit prostaglandin synthesis. Corticosteroids also increase lipocortin levels, which is a protein that reduces phospholipids, the substrate of phospholipase a.

Finally, glucocorticoid reduces the appearance of cyclo-oxygenase in inflammatory cells, thus reducing the amount of enzyme to produce prostaglandin.

Glucocorticoid reduces capillary base due to inhibiting the activity of kinine and bacterial internal toxins and reduces the amount of hydrophilia by base leukemia.

Dynamic pharmacokinetics

absorption: Biological use is approximately 80%. Maximum effect 1-2 hours after taking the drug. Effect time is about 30-36 hours.

The distribution of drugs is widely distributed in tissues, through the brain blood barrier and secretion into the milk. Distribution volume 0.7-5 liters/kg.

Methylprednisolon metabolism is metabolized in the liver, like metabolism of hydrocortisone.

Elimination: The metabolic excreted in the urine. Half life is approximately 3 hours.

Before taking Methylprednisolone Blue 4mg anti -inflammatory, hormonal disorders (100 tablets)

How to use

Methylprednisolone Blue is oral.

Dosage

The starting dose of methylprednisolone tablets may vary from 4 mg to 48 mg of methylprednisolone/day, depending on the disease.

Unwanted effects can be reduced by using the lowest effective doses in the shortest time.

Dosage maintenance depending on the clinical response of each patient, usually 3-7 days in case of rheumatism (except for acute heart low), imaging allergies to the stomach or respiratory tract, eye disease.

If the response is not achieved after 7 days of treatment, it is necessary to re -evaluate to have appropriate initial guesses.

If the response is achieved, should gradually reduce the daily dose or terminate treatment in cases of acute diseases such as (seasonal asthma, skin peeling dermatitis, acute loss of inflammation). Or the lowest maintenance dose is effective in chronic diseases (rheumatoid arthritis, systemic lupus, systemic erythematosus, cerebral asthma, atopic dermatitis).

In chronic diseases, especially rheumatoid arthritis, the reduction of the dose from the initial dose to the maintenance dose is carried out according to clinical assessment. Reduce no more than 2 mg in about 7-10 days. In rheumatoid arthritis, the treatment is maintained at the lowest possible level.

In a daily -distance therapy, the lack of minimum corticosteroids daily is doubled and used as a single Lunarity at 8 am. Dosage depends on the treatment and response of the patient.

Elderly: Treatment for elderly patients, especially if long -term treatment should be paid attention to the common side effects of corticosteroids in old age, especially osteoporosis, diabetes, high blood pressure, sensitive to infections and thinning skin.

Children: In general, the dosage for children must be based on the clinical reaction and depending on the doctor's decision. The treatment should be limited to the minimum dosage in the shortest time. If possible, use a single daily oral dose.

Reference recommendations in some cases:

Heavy rheumatoid arthritis: 12 - 16 mg, moderate weight: 8 - 12 mg, average: 4-8 mg, children: 4-8 mg.

Systemic dermatitis: 48 mg.

Lupus erythema body: 20 - 100 mg.

Rheumatoid fever: 48 mg until normal ESR tests for 1 week. allergies: 12 - 40 mg.

Bronchial asthma: Maximum 64 mg of a single dose of 100 mg.

Eye inflammation: Taking a dose of 12-40 mg.

Blood disorders and leukemia: 16 - 100 mg.

Malignant Ulygho: 16 - 100 mg.

ulcerative colon 16-60 mg.

Crohn's disease: 48 mg at the acute stage.

Tibetan transplant: 3.6 mg/kg/day.

Sarcoid disease: 32-48 mg oral daily.

Confucius blood vessel disease/rheumatoid arthritis: 64 mg.

conventional pemphigut: 80 - 360 mg.

There is no special requirement on drug treatment after use.

The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

In these cases, it is necessary to consider to make the right decision to suspend or stop using Glucocorticoid.

Handling: In case of overdose, no specific antidote, only support for support and symptoms. Methylprednisolone can be separated.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using methylprednisolone Blue 4mg, you may experience unwanted effects (ADR).

Common, ADR> 1/100

The immune system: infection.

Endocrine system: Cushing syndrome.

Metabolism and diet: Keep salt water.

Mental: Abnormal, easy -to -agitation.

Eye: cataracts.

Circulation system: High blood pressure

Digestive system: Peptic ulcer (capable of puncturing the digestive tract and gastrointestinal bleeding)

Skin and subcutaneous tissue: Atrophy of skin, acne.

Bone muscle and connective tissue: muscle weakness, growth retardation.

Other: Slow healing wounds.

Uncommon, 1/1000

No report.

Instructions on how to handle ADR

In the level indications, Glucocorticoid should be used at the lowest doses and in the shortest time of clinical effect.

After a long -term treatment with glucocorticoid, if the hill -pituitary - pituitary - adrenal is likely to occur, the urgent thing is to simplify the dose of glucocorticoid step by step, instead of sudden stop

Applying treatment to avoid continuous effects of drugs with pharmacological effects. Using a single dose of the day causes less ADR than the doses of split, and the day -by -way therapy is the best measure to minimize the inhibition of adrenal glands and other ADRs. In a single dose every day, every two days, in the morning.

Monitoring and periodic evaluation of osteoporosis parameters, hemorrhage, glucose tolerance, eye effects and blood pressure.

Preventive gastric and duodenal ulcer prophylaxis with H2 - histamine anti -receptor drugs when using high doses of methylprednisolone.

All patients treated with long -term with glucocorbcoids need to use calcium supplements to prevent osteoporosis.

People who are likely to be immunosuppressive due to Giucocorticoid should be warned about the likelihood of infection.

Patients who are about to have surgery may have to use glucocorticoid supplements because of the normal response to stress has been reduced due to the inhibition of hill - pituitary - adrenal glands.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Methylprednisolone Blue 4mg contraindicated drug in the following cases:

Patients with hypersensitivity to drug ingredients.

is using a living virus vaccine.

Severe bacterial infections except for bacterial and meningitis.

Skin damage due to viruses, fungi or tuberculosis.

Caution when using

Patients with diabetes, hypertension, stomach ulcers, duodenal ulcer.

Do not stop the drug suddenly.

Children, pregnant and lactating women.

The subjects should be noted before taking methylprednisolone blue: the elderly, pregnant women, nursing women, children under 15 years old, people with liver failure, kidney failure, people who are allergic to any substance in the ingredients of the drug ... or the object of myastheniah, liver coma, stomach ulcer.

The ability to drive and operate machinery

The effect of corticosteroids on the ability to drive and operate machinery has not been systematically assessed. Unwanted effects such as dizziness, dizziness, visual disorders and fatigue may occur after corticosteroid treatment.

If affected, patients should not drive or operate machinery.

Pregnancy

Consider and consult a doctor or pharmacist before taking the drug. Only use the drug when really necessary.

breastfeeding period

Excessive drugs through breast milk. Used only if the benefits for the mother are more likely to be at risk for the baby.

Drug interaction

CYP3A4 touch substance: Rifampicin, carbamazepin, phenobarbital, phenytoin. Reducing methylprednisolone concentration in plasma. Ketoconazole, diltiazem, ethinylelestradiol, norethindron, cyclosporin, clarithromycin, erythromycin, HIV-protease inhibitors, grapefruit juice, troleandomycin. Increases methylprednisolone levels in plasma.

Aminoglutethimid: The adrenal inhibition caused by aminoglutathimids can worsen the changes in hormones arising from prolonged glucocorticoid therapy. Methylprednisolone may increase high -dose aspirin clearance, leading to serum salicylate concentration. Methylprednisolone treatments may increase salicylate concentration in serum, leading to an increased risk of salicylate poisoning. The risk of hypoglycemia also increases when using Corticosteroids with amphotericin B, xanthin or Beta2 fortunes.

Storage

Store in a dry, cool place. Avoid light, temperature below 30⁰C.

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