Metiocolin solution 100mg CPC1 Hanoi treatment for children with underdeveloped intelligence (4 blisters x 5 tubes x 10ml)

Dosage form Box of 4 blisters x 5 tubes
Specifications Citicolin

Ingredient

Thành phần cho 10ml

Composition information	Content
Citicolin	100mg

Uses

Indications

Metiocolin 100mg is indicated in the following cases:

Treatment of biosynthesis of phospholipids on nerve cell membranes, anti -brain damage, enhance neurotransmitter function.

Treatment:

Children with mental retardation.

Children with sleep disorders, or startled crying at night.

Conscious disorders due to head injury or after brain surgery.

Supporting exercise with patients with hemiplegia after a stroke.

Parkinson's disease shows severe tremor.

Intelligence of old age (including Alzheimer's disease).

Pharmacy

active ingredient Citicoline (in the form of sodium citicolin) has the effect of stimulating acetylcholine production, stimulating phospholipid biosynthesis on nerve cell membranes, helping non -widespread stuffing areas, which help increase neurotransmitters, enhance cognition, restore and restore functions brain.

citicolin is a complex organic substance that functions as an intermediate in the biosynthesis of cell phospholipid cells. Citicolin is also known as CDP - Choline or Cytidin Diphosphate Cholin (Cytidin 5' - Diphosphocholin). Citicolin belongs to the group of biological molecules in the living systems called nucleotid plays an important role in cell metabolism.

citicolin is the precursor of phosphatidylcholin. The brain uses priority for acetylcholin synthesis, limiting the amount of cholin used in phosphatidylcholin production. When the demand for acetylcholin increases or cholin reserves in the brain low, phospholipids in the nerve cell membrane can be metabolized to provide the necessary cholin. Therefore, external citicolin helps maintain the integrity and function of the nerve cell membrane.

citicolin helps restore nerve cell membranes through increased phosphatidylcholin synthesis, restoring cholinergic nerve cells through acetylcholin production, reducing free fatty acids at a nerve damage caused by stroke.

In addition to phosphatidylcholin, citicolin is also an intermediate in Sphingomyelin synthesis, another phospholipid component of the nerve cell membrane. Citicolin helps restore sphingomyelin after ischemic.

citicolin also restores cardilipin, a phospholipid component in mitochondria, helps maintain mitochondria.

citicolin against beta - amyloid deposition, a nerve -causing protein is said to play a role in Alzheimer's pathophysiology. The characteristic lesions in Alzheimer's disease are plaque formation and crowds and then in the brain. The degree of cognitive dysfunction and neurodeless degeneration in Alzheimer's disease is proportional to the accumulation of beta-amyloid.

pharmacokinetic

absorption

citicolin absorbs well after oral, absolute bioavailability of the drug is approximately 99%. Healthy pharmacokinetic studies show that citicolin is quickly absorbed, less than 1% is not absorbed and eliminated through feces.

Because it is difficult to determine the plasma citicolin levels, in the tests only determine the free cholin concentration or the total radioactive capability of plasma within the limit of an amount equivalent to citicolin. Plasma cholin concentration increases significantly after drinking.

On the radiation spectrum obtained after taking citicolin 300mg, there are two peaks equivalent to citicolin. The first peak appears approximately after 1 hour of taking the drug (1.5 mcg/ml), perhaps associated with the unprocessed citicolin mixture and its metabolic product (cholin and cytidine diphosphate).

The second peak appears after 24 hours of medication (3 mcg/ml) and maybe this is the cause of slow absorption and continues to accumulate medication after this period.

Distribution

cholin obtained from citicolin through the brain blood barrier, perhaps the source of raw materials for synthesizing acetylcholin and lecithin (phosphatidyl cholin). A large amount of citicolin is in the form of combining tissues and/or used in biosynthetic and degenerative paths, including lecithin synthesis/lipid cell membrane.

Metabolism

citicolin is metabolized in intestinal and liver cells. Citicolin products are hydrolyzed in the intestine, choline and cytidin. After absorption, Choline and cytidin are distributed throughout the body, go into the circulatory system to participate in biosynthesis processes and pass through the brain barrier to re -synthesize citicolin in the brain.

Elimination

A small amount of drugs are eliminated through urine (2 - 3%) and feces (less than 1%). There are approximately 12% of the drug excreted as respiratory carbondioxid. The selling time of citicolin is 3.5 hours (the first peak concentration) and 125 hours (the second peak concentration).

Before taking Metiocolin solution 100mg CPC1 Hanoi treatment for children with underdeveloped intelligence (4 blisters x 5 tubes x 10ml)

How to use

Take oral use.

Dosage

The acute recovery stage (6 - 12 months).

Adults

2 tubes 10ml x 3 times/day.

Children

1 tube 10ml x 3 times/day.

Chronic enhancement

Use oral dose as recovery stage.

Use drugs for the elderly

Do not adjust the dose when using citicolin for the elderly.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? In a diagonal study, with placebo back in a short time, 12 healthy volunteers took Citicolin at a dose of 600mg, 1,000mg or placebo for 5 consecutive days.

A transient headache occurs over 4 users with a dose of 600mg, 5 users of 1,000mg and 1 placebo users. There are no changes and abnormalities observed about hematology, clinical and nervous testing.

In case of overdose, stop using the drug. Contact your doctor or pharmacist if you take more medication than the recommended dose in this tutorial or more than the doctor's prescription.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Metiocolin 100mg, you may experience unwanted effects (ADR).

may experience symptoms such as hypotension, chest tightness, fatigue, insomnia, headache, dizziness, nausea, anorexia ...

Unwanted effects are often rare and transient including:

Gastrointestinal disorders: nausea, vomiting, anorexia, epigastric disorders, diarrhea.

Eyes: Couple.

cardiovascular: flushing, changing blood pressure, uncomfortable feeling.

Nervous system: insomnia, rarely headache, dizziness, nausea, stimulation, convulsions. liver: abnormalities in liver function tests, sometimes GOT, GPT can occur.

hypersensitivity: If the rash is seen, the medication should be stopped. shock: rarely occur shock, if you see hypotension, chest tightness, shortness of breath should stop taking the drug and treat with appropriate drugs.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Metiocolin 100mg contraindicated drug in the following cases:

Patients with hypersensitivity to citicolin or ingredients of preparations.

Patient increases the sympathetic nervous system.

Cerebral vascular disease.

Caution when using

citicolin may cause hypotension and in case of need for hypotension can be treated with corticosteroids or sympathetic drugs.

In case of prolonged bleeding in the brain, do not use citicolin more than 1,000mg/day.

Do not drink alcohol and alcoholic beverages while using citicolin.

When prolonged intracranial hemorrhage: Do not use more than 1,000mg of citicolin/day and use intravenous dosage form (must be slow intravenous infusion).

In acute and emergency pathological condition, citicolin should be used in combination with drugs that reduce intracranial pressure or lower body heat. If the cerebral bleeding continues, avoid high doses of citicolin (> 500mg), as it can increase the blood flow in the brain. If necessary, low -dose citicolin can be used (100 - 500mg, 2-3 times/day).

The ability to drive and operate machinery

The drug can be stunned, lower blood pressure, so it should be cautious when used for drivers and machinery.

Pregnancy

Currently, there has been no full research on good control of citicolin use during pregnancy. Citicolin is only used during pregnancy when the benefits are greater than the risk to the fetus.

Breastfeeding period

Currently, there has not been a complete study of good control of citicolin use for nursing women. Must be cautious during breastfeeding because it is still unknown whether citicolin is excreted in milk or not.

Drug interaction

Do not use citicolin simultaneously with drugs containing meclophenoxat (or Centrophenoxin).

citicolin increases the effects of L-DOPA.

Storage

Store in closed packaging, avoid moisture, avoid light, temperature below 300C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.