Metoclopramid Kabi 10mg Fresenius Kabi solution for prophylaxis of vomiting and postoperative nausea or radiotherapy (12 tubes x 2ml)

Dosage form Box of 12 tubes x 2ml
Specifications Metoclopramide

Ingredient

Thành phần cho 2ml

Composition information	Content
Metoclopramide	10mg

Uses

indications

Metoclopramid Kabi 10 drugs are indicated in the following cases:

Adults:

Preventive vomiting and postoperative nausea.

is a second -hand choice to prevent vomiting and nausea that appear late due to chemotherapy. Acetylcholin. The drug increases the peristalsis of taste, duodenum, and colon. Metoclopramid reduces the upper part of the stomach and increases the contractions of the taste. Therefore, combining the two effects on the stomach quickly and reducing reflux from the duodenum and stomach to the esophagus. These effects are important in using metoclopramid as a peristaltic drug. The anti-vomiting essence of Metoclopramid is due to the direct dopamine resistance on the receptor and vomiting launch area and due to the antagonistic effect on the Serotonin-5HT3 receptor.

Dynamic pharmacokinetics

Quickly distributed drugs into most tissues and easily through the brain and placenta barriers. The concentration of drugs in milk may be higher in plasma. 30% of the drug excreted in the form of unchanged urine, the rest excreted through urine and bile after connecting with sulfate or glucuronic acid. Half a lifetime of the drug during the circulation is about 4-6 hours, but it can also be up to 24 hours in patients with impaired kidney or cirrhosis.

When intramuscularly, the drug starts to work after 10 to 15 minutes, when intravenously after 1-3 minutes.

Before taking Metoclopramid Kabi 10mg Fresenius Kabi solution for prophylaxis of vomiting and postoperative nausea or radiotherapy (12 tubes x 2ml)

How to use

intramuscularly or intravenous intravenous for at least 3 minutes.

Dosage

Adults:

Preventive vomiting and postoperative nausea: Recommendations of 10 mg. mg/kg/day.

With all the indications: recommend the dose of 0.1 - 0.15 mg/kg x up to 3 times/day, intravenously.

Maximum dose: 0.5 mg/kg/day. age weight Dosage Time/day

3 - 5 years old 15 - 19 kg 2 mg Maximum 3 times/day

5 - 9 years old 20 - 29 kg 2.5 mg Time/day

9 - 18 years old 30 - 60 kg 5 mg Maximum 3 times/day

15 - 18 years old 60 kg 10 mg Time/day

Preventive vomiting and nausea appear late due to chemotherapy: Maximum within 5 days.

Elderly people: Should consider losing the dose of the drug based on liver and physical function. 50%. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Periodic disorders, drowsiness, reduced cognitive ability, confusion, hallucinations, cardiac arrest.

Handling

In the event of a pagan disorder, maybe due to an overdose or not, Metoclopramid should be stopped and used for symptomatic medications including benzodiazepine in young children and/or anti -cholinergic drugs for Parkinson's treatment in adults.

Need to treat symptoms and continuous monitoring of cardiovascular and respiratory functions depending on the patient's clinical condition.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug often has unwanted effects (ADR) such as:

The undesirable effects below are listed according to the organization classification.

The frequency of meeting conventions is as follows: Very common (≥ 1/10), common (≥ 1/100,

Organizational classification frequency Cytochrome B5 Reductase, especially in infant sulfhemoglobin blood, is mainly due to simultaneous use with high -dose sulfur release:

cardiovascular disorders The circuit

unknown cardiac arrest, occurring in a short time after the injection line, may occur after the heart rate slow, sinus stops, especially with intravenous preparations; extending the QT distance on the electrocardiogram; Twisted Clearly big breasts in the South Visual > Neurological disorders Yen less common muscle disorders, motor disorders, reduced cognitive ability

Late exercise may not be recovered, during or after prolonged treatment, especially in elderly patients, malignant neuroleptic syndrome Enlightenment

rare Confusion Clearly shock, fainting after injection, acute hypertension in patients with adrenal marrow tumors

The reactions are related or often occurs when high doses include:

Periodic disorders: muscular disorders or acute movement disorders, Parkinson's syndrome, restless standing, even after using a single dose, especially in children and young people.

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Metoclopramid Kabi 10 drug is contraindicated in the following cases:

Hypersensitivity to Metoclopramid or any ingredients of the drug. Mobility due to sedation. Under 1 year of age due to the increased risk of foreign towering disorders on this object.

Be cautious when using

Please see more information about the drug in the instruction sheet of the use of the drug attached.

Causes of caution when taking the drug:

neurological disorders:

There may be symptoms of alphabetical disorders, common in children and young people and/or when using high doses. These reactions usually occur in the early stages of drug use, some cases occur after a single dose. Should stop the drug as soon as there is a expression of the percentage disorders. In most cases, these symptoms are completely lost after stopping the drug. However, some cases need to use symptomatic medication (benzodiazepin in children and/or anti -antacids of Parkinson's treatment in adults).

The distance of at least 6 hours, including vomiting or does not use one dose to avoid the risk of overdose.

Prolonged treatment with metoclopramid can cause late movement disorders, many cases of non -recovery, especially in the elderly. Therefore, do not extend the treatment time for more than 3 months. It is necessary to stop taking the drug as soon as there are manifestations of late movement disorders.

Malignant neuroleptic syndrome has been reported to Metoclopramid for use as well as in collaboration with other sedatives. Patients need to stop the drug and take appropriate treatment as soon as the manifestations of malignant neurolithic syndrome.

Be careful to monitor patients with neuropathy and patients being treated with medications with central effects.

Metoclopramid may worsen Parkinson's symptoms.

Methemoglobin blood:

Some cases of blood methemoglobin may be associated with NADH cytochrome B5 Reductase deficiency. When the patient shows methemoglobin, it is necessary to stop the drug immediately and have appropriate treatments such as using methylene green. In these cases, never reusing Metoclopramid for patients.

cardiovascular disorders:

Some cases of serious adverse adverse reactions have been reported including circulatory, serious slow heart rate, cardiac arrest and extending the QT period after Metoclopramide injection, especially intravenous injection.

Be careful to monitor patients using Metoclopramid, especially in the case of intravenous medication for the elderly, patients with heart disease disorders (including extension of QT), patients with electrolyte disorders, bradycardia and patients with other drugs that are at risk of extending the QT range.

In case of intravenous medication: slow intravenous injection for at least 3 minutes to reduce the risk of adverse reactions such as hypotension and restless sitting.

kidney failure or liver failure:

Recommendations to reduce the dose in patients with serious liver or liver failure.

The effect of the drug on driving and operating machinery

metoclopramid can cause drowsiness, dizziness, dysfunction, muscle disorders and can affect the vision and driving ability as well as operate the drug user of the drug user.

Using drugs for women during pregnancy and lactation

Pregnancy:

Many data on pregnant women (with over 1,000 output indicators) show that metoclopramid does not cause teratogenic or toxicity to the fetus, so it can be used during pregnancy if necessary. Due to the pharmacological properties of Metoclopramid similar to other sedatives, the use of drugs at the end of pregnancy may cause a risk of extracurricular syndrome on the child. Therefore, avoid using metoclopramid at the end of pregnancy; In case of drug use, closely monitoring on the above manifestations.

Breastfeeding period:

Metoclopramid excreted small amounts of breast milk, so breastfed babies are at risk of adverse drug reactions. Therefore, it is not recommended to use metoclopramid during breastfeeding. On breastfeeding women use metoclopramid, it is necessary to consider stopping the drug.

Drug interaction

Contraindicated Metoclopramide combination with levodopa or dopamine owners due to mutual antagonism.

Coordination should be avoided:

Alcohol can increase the central neurological inhibition effect of Metoclopramid.

Coordination needs to consider:

Because metoclopramid increases the peristalsis of the gastrointestinal tract, it can change the absorption of some drugs.

anti -cholinergic drugs and morphine derivatives: anti -cholinergic drugs and morphine derivatives may have antagonistic compatible with metoclopramid on the effects of the gastrointestinal tract. Quan): The combination of central painkillers and Metoclopramid can increase the impact on the mental influence. Increases the risk of serotonin syndrome. When used in combination, plasma digoxin concentration should be closely monitored. When used in combination, plasma cyclosporin levels should be closely monitored. The consequences of this interaction clinically. Paroxetin increases the level of exposure to Metoclopramid in patients. Although the clinical consequences of interaction are not well known, it is necessary to closely monitor patients to detect adverse reactions.

Storage

Avoid light, temperature not exceeding 30 ° C.

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