Metpredni 4 A.T anti -inflammatory, treat rheumatoid arthritis, lupus erythematosus (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Methylprednisolone

Ingredient

Composition information	Content
Methylprednisolone	4mg

Uses

indications

Metpredit 4 A.T is indicated in nonspecific therapy that requires anti -inflammatory and immunosuppressive effect of glucocorticoid:

Treatment of rheumatoid arthritis, systemic lupus system, some vasculitis, temporal arteritis and inflammation around the artery, sarcoid disease, bronchial asthma, ulcerative colitis, hemolytic anemia, granulocytopenia and severe allergens including anaphylaxis. Treatment of nephropathy syndrome.

Due to methylation predisolone, the effect of corticosteroids metabolizes salt has been excluded, so there is very little risk of keeping Na+ and causing edema. The anti -inflammatory effect of methylprednisolone increases by 20% compared to the effect of Prednisolone, 4 mg methylprednisolone is valid as 20 mg of hydrocortisone.

Glucocorticoid uses systemic sugars to increase the number of neutrophils and reduce the number of Iymi cells, eosin leukemia, single -blood leukocytes in peripheral blood.

Glucocorticoid also inhibits the function of Iymo cells and macrophages, limits the production of inflagen-1 inflated inflates, lice, fever, collagenase and elastase enzymes, and plasminogen-active hypertrophy. Glucocorticoid acts on lymphocytes that reduce the production of Interleukin-2.

Glucocorticoid also affects inflammatory reaction by reducing prostaglandin synthesis due to phospholipase activation A2. Glucocorticoid increases the concentration of some membrane phospholipids that inhibit prostaglandin synthesis. Glucocorticoid also increases the level of lipocortin is a protein that reduces phospholipids, the substrate of phospholipase A2. Finally, glucocorticoid reduces the appearance of cyclooxygenase in inflammatory cells, thus reducing the amount of enzyme to produce prostaglandin.

Glucocorticoid reduces capillary permeability due to inhibition of the activity of kinin and bacterial internal toxins and reduces the amount of histamine released by base leukocytes.

Dynamic pharmacokinetics

Absorption: Biochemical is approximately 80%. Plasma concentration reaches a maximum of 1–2 hours after taking the drug. Biological effect time (inhibiting pituitary gland) is about 1.5 days, can be considered a short effect.

Metabolism: methylprednisolone is metabolized in the liver, like metabolism of hydrocortisone.

Elimination: The metabolites are excreted in the urine. Selling time is approximately 3 hours.

Before taking Metpredni 4 A.T anti -inflammatory, treat rheumatoid arthritis, lupus erythematosus (10 blisters x 10 tablets)

How to use

Metpredit 4 A.T uses oral.

Dosage

Start dose: 6–10 mg of methylprednisolone per day. The necessary dose to maintain the desired treatment is lower than the dose needed to achieve the initial effect and must determine the lowest dose that can achieve the necessary effect by reducing the dose gradually step by step until the signs or symptoms increase.

When you need to take large doses for a long time, apply medication therapy the day after control of the process of the disease, there will be fewer side effects because of the recovery time between each dose. In a daily therapy, use a single dose of methylprednisolone every 2 days in the morning according to the span of natural secretion glucocorticoid.

Rheumatoid arthritis: The starting dose is 4–6 mg of methylprednisolone per day. During the exacerbation, taking a dose higher than 16–32 mg/day, then gradually decreases quickly.

Chronic arthritis in children with life -threatening complications: Sometimes using methylprednisolone in attacking therapy, at a dose of 10–30 mg/kg/batch (often used 3 times).

ulcerative colitis: severe acute period, taking 8–24 mg/day.

Nephropathy syndrome: Start using daily methylprednisolone doses of 0.8–1.6 mg/kg for 6 weeks, then gradually reduce the dose for 6–8 weeks.

Anemia hemolysis due to immunity: Take 64 mg/day. Methylprednisolone must be treated for at least 6–8 weeks.

Sarcoid disease: methylprednisolone 0.8 mg/kg/day, to relieve the disease. Using maintenance dose is low 8 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

Actively monitor for timely management measures.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Metpredni 4 A.T, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Central nerve: Insomnia, nervousness is easily agitated.

digestion: Increase appetite, indigestion. Skin: Skin.

Endocrine and metabolism: diabetes.

nervousness and bone: joint pain.

Eyes: cataracts, glaucoma.

Respiratory: Nosebleeds.

Uncommon, 1/1000

Central nerve: dizziness, convulsions, mental disorders, fake tumors in the brain, headache, mood change, delirium, hallucinations, refreshment.

Cardiovascular: edema, hypertension. skin: acne, skin atrophy, bruising, tissue hyperpigmentation.

Endocrine and metabolism: Cushing syndrome, pituitary inhibitor - kidney, slow growth, glucose intolerance, reduced blood potassium, alkaline contamination, amenorrhea, sodium and water, hyperlem of blood glucose.

digestion: stomach ulcers, nausea, vomiting, bloating, esophageal ulcer, pancreatitis.

nervousness and bone: muscle weakness, osteoporosis, fracture.

Other: Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Metpredit 4 A.T Contraindications in the following cases:

Too hypersensitivity to any component in the formula.

Severe infections, except for bacterial shock and meningitis.

Viral, mushroom or tuberculosis skin lesions.

using a living virus vaccine.

Be cautious when used

The drug contains lactose. Patients with rare genetic disorders such as galactose intolerance, lapp lactase deficiency or glucose -galactose absorption disorders do not take this drug.

Use cautiously in patients with osteoporosis, new blood vessels, mental disorders, stomach ulcers, duodenal ulcers, diabetes, hypertension, heart failure and growing children.

Due to the risk of unwanted effects, caution must be used with all body corticosteroids for the elderly, with the lowest doses and in the shortest possible time.

Acute adrenal insufficiency may occur when stopping the drug suddenly after a long time of treatment or when stress.

When high doses, can affect the effects of vaccine vaccine.

The ability to drive and operate machinery

The drug can cause unwanted side effects such as dizziness, psychosis, hallucinations, convulsions, refreshing so it is best not to use methylprednisolone when driving or operating machinery.

Pregnancy

For extension of body corticosteroids for mothers can lead to mitigation of the babies of newborns. In general, using methylprednisolone in pregnant people requires consideration of benefits that can be achieved compared to the risks that may occur with mother and child.

The period of breastfeeding

Non -contraindicated corticosteroids for breastfeeding women.

Drug interaction

methylprednisolone is an enzyme induction cytochrome P450 and is the substrate of isoenzyme CYP3A, so the drug affects the metabolism of cyclosporin, erythromycin, phenobarbital, phenytoin, carbamazepine, ketoconileole, ketoconolate, ketoconolole Rifampicin.

Phenytoin, Phenobarbital, Rifampicin and diuretics decreased potassium can reduce the effectiveness of methylprednisolone.

methylprednisolone may cause hyperlemor of blood glucose, so higher insulin dose is needed.

Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.