Metrima 100 Pharmacy 3-2 vaginal tablets for treatment of candidiasis (1 blister x 6 tablets)

Dosage form Box of 1 blister x 6 tablets
Specifications Clotrimazol

Ingredient

Composition informationContent
Clotrimazol100mg

Uses

indications

Metrima®100 drug is indicated for treatment on the spot treatment Candida in vulva, vagina.

Pharmacological

Clotrimazol is a synthetic antifungal drug belonging to a broad spectrum imidazole group used on the spot cases of fungal diseases on the skin. The mechanism of acting of clotrimazol is linked to phospholipids in the fungal cell membrane, changing the permeability of the membrane, causing loss of intracellular essential substances that lead to the destruction of mushroom cells.

Effective spectrum:

  • In vitro, Clotrimazol have the effect of restraining and killing fungi, depending on the concentration, with Trichophyton Rugbrum, Trichophyton Mentagrophytes, Epidermophyton Flocosum, Microsporum Canis and Candida species. Aureus, Streptococcus Pyogenes), Gram -negative bacteria (Bacteroides, Gardnerella Vaginalis), Trichomonas. But the tests of fungal sensitivity with drugs do not help predict which fungus will respond to treatment.
  • Natural resistance with rare clotrimazol. Azol.

    Vaginal lines, Clotrimazol is very little absorbed into the blood: After placing the Clotrimazol - 14C 100 mg vagina, the average serum peak concentration is only 0.03 micrograms Clotrimazol/ml after 1-2 days.

    distribution

    No report.

    transformation

    No report.

    Elimination

    No report.

    • Before taking Metrima 100 Pharmacy 3-2 vaginal tablets for treatment of candidiasis (1 blister x 6 tablets)

    How to use

    Dip the pill in cool boiled water for about 20 seconds, then put deep into the vagina. Keep the position in 15 minutes after placing the drug.

    Should put the drug in the evening before going to bed.

    Dosage

    Common dose: 2 tablets are placed deep in the vagina every night before going to bed for 3 consecutive days. Or place 1 tablet deep in the vagina before going to bed for 6 consecutive days.

    Do not take medicine for children under 16 years old.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    No specific antidote.

    However, in case of accidentally drinking, rarely have to wash the stomach and should only be considered if there are clinical symptoms of clear overdose (for example, dizziness, nausea or vomiting). The stomach should only be performed when the respiratory tract has been fully protected.

    What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

    Side Effects

    When using Metrima®100, you may experience unwanted effects (ADR).

    Common, ADR> 1/100

  • No report.

    • Uncommon, 1/1000

  • No report.

    • Not determined frequency

  • The immune system: allergic reactions (fainting, hypotension , shortness of breath, urticaria , itching).

    • Reproduction system: Peeling the genitals, itching, rash, edema, erythema, discomfort, burning, irritation, pelvic pain, vaginal bleeding.

  • Digestive system: abdominal pain.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Contraindicated

    Metrima®100 drug is contraindicated in the following cases:

  • Sensitive to Clotrimazol or any ingredients of the drug.

    • Be cautious when using

    need to consult a doctor if the patient first has symptoms of Candida vaginitis.

    Before using the drug, it should be notified to the doctor if in any of the following cases:

  • There have been more than twice suffering from vaginitis due to candidiasis in the past 6 months.
  • There is a history of sexually transmitted diseases or sexually transmitted sexually transmitted diseases.

    • Pregnancy or suspicion of pregnancy.

  • Patients under 16 or over 60 years old.
    • Hypersensitivity to imidazol or other vaginal antifungal drugs.

    Do not use the drug and consult your doctor if the patient has any of the following symptoms:

  • Unusual vaginal bleeding.

    • Vaginal or vaginal ulcer, skin burning or blisters.

  • Abdominal pain or difficulty urinating.

    • There are any side effects such as red, irritation or swelling related to treatment. fever or chills. nausea or vomiting.

    diarrhea .

  • The vagina has a bad odor .

    • Patients should consult a doctor if the symptoms do not get better after 1 week of taking the drug. It can be reused if the fungal infection recurs after 7 days. However, if the fungal infection recurs more than 2 times within 6 months, the patient should consult a doctor.

    Must treat the drug enough time despite the symptoms of relief.

    Avoid sources of infection or re -infection

    The ability to drive and operate machinery

    Metrima®100 drugs affect the ability to drive or operate machinery?

    The drug does not affect or affect the ability to drive or operate machinery.

    Pregnancy

    Should Metrima®100 be pregnant?

    There are very little data from the use of clotrimazol in pregnant women. Animal studies with clotrimazol have shown reproductive toxicity when taking high doses. At low body exposure level after using vaginal clotrimazol, harmful effects on reproductive toxicity are not predicted.

    can use clotrimazol during pregnancy, but only when the doctor or midwifery monitor.

    Breastfeeding period

    Should Metrima®100 be breastfeeding?

    Animal's pharmacotic/ toxic data has shown the excretion of clotrimazol/ metabolites in milk after intravenous injection. Can not exclude risks for breastfed babies. Must decide to stop breastfeeding or stop/ avoid using clotrimazol by taking into account the benefits of breastfeeding and the benefits of the mother's treatment.

    Drug interaction

    drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

    There is no notice of the effect of copper or antagonism between clotrimazol and nystatin, amphotericin B or flucytosin and C. albicans.

    Simultaneously use Clotrimazol to place the vagina and oral tacrolimus (FK-506; Inhibiting the enemy's exemption) can lead to an increase in the concentration of Tacrolimus in plasma and similar to syirolimus. Therefore, patients should be closely monitored with signs and symptoms of Tacrolimus or Sirolimus overdose, if necessary, the corresponding concentration in plasma can be determined.

    Laboratory tests have shown that when used simultaneously, the drug can damage the latex condom. Therefore contraceptive effect may decrease. Advise patients to use contraception instead for at least 5 days after using this drug.

    Storage

    In a cool dry place, temperatures below 30 ° C, avoiding light.

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