Metrima-M F.T Pharma treatment for cervicitis, vaginitis and vulva (10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Metronidazol, clotrimazol

Ingredient

Composition informationContent
Metronidazol500mg
Clotrimazol100mg

Uses

indications

Metrima-M drug is indicated in the case:

Treatment of cervicitis, vaginitis and vulva - vaginal inflammation caused by trichomonas vaginalis along with candida or bacterial infections.

Pharmacokology

metronidalzol

Metronidalzol is a 5-nitro-imidazole derivative, has a broad spectrum on protozoa such as amoeba, giargia and anaerobic bacteria.

The mechanism of action of Metronidazol is unclear. In parasites, the 5-nitro group of the drug is reduced into toxic mediators to the cell. These substances bind to the twisted structure of the DNA molecule that breaks these fibers and eventually causes dead cells. The effective average concentration of metronidazol and 8 mcg/ml or lower for most protozoa and sensitive bacteria. The minimum concentration of inhibition (mic) sensitive strains is about 0.5 mcg/ml or lower for most primary animals and sensitive bacteria. A strain of bacteria when isolated is considered to be sensitive to the drug when the mic does not exceed 16 mcg/ml.

Metronidalzol is a drug used in the treatment of protozoa such as Entamoeba Histolytica, Giardia Lamblia and Trichomonas Vaginalis. Metronidalzol is only resistant to one of the few cases. When infected with both anaerobic and anaerobic bacteria, Metronidazol must be combined with other antibacterial drugs.

Trichomonas vaginalis infection can be treated with Metronidazol oral oral oral use. Both women and men must be treated, because men can carry pathogens without symptoms. In many cases, it is necessary to treat vaginal drugs.

When bacterial/ vaginal infections, metronidazol, will cause the vaginal bacteria to return to ordinary infantry most patients taking drugs, Metronidazol does not impact on the normal vaginal bacteria.

Clotrimazol

Clotrimazol is a broad -spectrum antivirus drug used to treat skin diseases caused by various fungal species and also work on trichomonas, staphylococcus and bacteroides. No effect on lactobacilli.

The mechanism of acting of clotrimazol is to link with phospholipids in the fungal cell membrane, changing the permeability of the membrane, causing loss of intracellular essential substances leading to the destruction of mushroom cells.

In vitro, clotrimazol have the effect of restraining and killing fungi, depending on the concentration with Trichophyton Rugbrum, Trichophyton Mentagrophytop, Epidermophyton Flocosum, Microsporum Canis and Candida species.

Natural resistance with rare clotrimazol. Only a strain of Candida Guillidondri resistant to clotrimazol resistance. Cross resistance between azols is common.

pharmacokinetics

metronidazol

absorption

Metronidazole is less absorbed in the whole body after using vaginal lines. Selling time in plasma from 8 to 10 hours.

Distribution

cohesion with low plasma proteins, less than 20%. Quickly diffuse into the lungs, kidneys, liver, bile, cerebrospinal fluid, skin, saliva and vaginal discharge. Metronidazol passed the placenta and breast milk.

Metabolism

Metabolic mainly in the liver, forming two non -combined oxidant metabolites.

Elimination

Excretion mainly in the urine: about 35 - 65% of the absorbed dose is excreted in the form of constant or in the form of oxidative metabolites.

clotrimazol

Used on the skin or vaginal use, Clotrimazol is very few absorbed: After placing the vagina Clotrimazol - 14C 100 mg, the average serum peak concentration is only 0.03 micrograms clotrimazol/ml after 1-2 days and approximately 0.01 microgram/ml after 8 - 24 hours if using 5g clotrimazol cream - 14C 1%.

Before taking Metrima-M F.T Pharma treatment for cervicitis, vaginitis and vulva (10 tablets)

How to use

Dip pills in cool boiled water for about 20 seconds. Put deeply into the vagina 1 tablet in the evening before going to bed, holding the posture for 15 minutes after placing the drug. Use 7 days consecutive.

Dosage

Vaginal 1 tablet/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

No information.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Metrima-M drug, you may experience unwanted effects (ADR).

Very rare, ADR

  • Skin and subcutaneous tissue: local irritation such as itching, rash, allergic dermatitis due to contact.

    • Unknown frequency

  • Immune: allergic reactions.

    • Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    contraindicated

    Metrima-M drug contraindicated in the following cases:

    Patients are sensitive to any ingredients of the drug.

    Be cautious when using

    Metronidazole can cause immobility of treponema pallidum to create a false positive reaction of the Nelson solution.

    Metronidazole takes high doses of treatment of anaerobic infections and treatment of amoeba and Giardia can cause blood organs disorders and physical diseases.

    If irritated or sensitive when used to stop medication and appropriate treatment.

    The ability to drive and operate machinery

    does not affect.

    Pregnancy

    Do not use drugs, unless it is necessary and must be monitored by a doctor.

    The period of breastfeeding

    Do not take medicine, unless it is necessary and must be monitored by a doctor.

    Drug interaction

    Metronidazol

    Metronidazole increases anticoagulant oral effects, especially warfarin, so avoid use at the same time.

    metronidazol has a disulfiram -style effect. So do not use these two drugs simultaneously to avoid nervous effects such as psychosis, confusion.

    Simultaneous use of metronidazol and phenobarbital increases metronidazol metabolism, so Metronidazol is faster.

    Use Metronidazol for patients with high blood lithium concentration (because they are using lithium) will increase the concentration of lithium lithium increasing, toxic.

    metronidazole increases the effect of vecuronium is a non -reducing muscle relaxant.

    Clotrimazol

    There is no notice of the effect of copper or antagonism between clotrimazol and nystatin, amphotericin B or flucytosin and C. albicans.

    Tacrolimus concentration in the serum of people with liver transplant increases when used simultaneously with clotrimazol. Therefore, it should be reduced by Tacrolimus on demand.

    Storage

    Leave a cool dry place, avoid light, temperature below 30 ° C.

    Other drugs

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