Metrogyl Denta Unique Pharma dental gel treatment for chronic periodontal diseases (20g)

Dosage form Tube
Specifications Metronidazole, chlorhexidine

Ingredient

Composition information	Content
Metronidazole	10mg
Chlorhexidine	0.25%

Uses

indications

Metrogyl denta drug is indicated for treatment of chronic periodontal diseases to support traditional treatments.

Pharmacokology

Metronidazole is an antibacterial in the Inidazole group that works against a variety of anaerobic bacteria, including the main bacteria in the lower bacteria system in the lower periodontitis in adults. Metronidazol has bactericidal effect against Bacteroides spp.

There are several anaerobic fermented bacteria such as Actinobacillus Actinomycetemcolmitans sensitive to metrotidazole concentration achieved after applying metrogyl denta. The appearance of metronidazole resistance is rarely reported, and only with high doses after prolonged use. Metronidazole does not make pictures towards the microorganisms.

Dynamic pharmacokinetics

There are no specific studies on pharmacokinetics with metronidazole gel.

With tablets, the half -life after using a single dose is 6 - 7 hours.

Metronidazole is less linked to plasma proteins. It is easy to penetrate into the tissues and the apparent distribution is large equivalent to the distribution of about 70 - 95% of the body mass.

Metronidazole is eliminated in humans mainly through metabolic due to chain oxidation, hydroxylation or conjugated. After 24 hours, the amount of metabolites detected in urine accounts for 35 - 65% of the dose.

Before taking Metrogyl Denta Unique Pharma dental gel treatment for chronic periodontal diseases (20g)

How to use

just for external use. Only used in dentistry.

Apply a sufficient amount of metrogyl denta to create a thin layer around the teeth.

Dosage

2 times daily, the dose varies with each person, depending on the number of teeth that need to be treated.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose?

Metronidazole's oral toxicity is determined to be greater than 5 g/kg (the highest dose used) in white rats.

What to do when forgetting a dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using metrogyl denta you may experience some unwanted effects (ADR).

Because the concentration in plasma after applying the gel on the spot is low, the risk of adverse effects is also low. The most common disadvantage is usually in place and is directly related to applying the drug, such as a bitter and sensitive taste. Wild headaches are reported.

ADR processing direction

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

metrogyl denta contraindicated in the case:

Hypersensitivity to Metronidazole and Chlorhexidine (excipients).

Be cautious when using

In some patients, Metronidazole may have the same effect as disulfiram on the metabolism of alcohol, leading to intolerant symptoms.

The ability to drive and operate machinery

no.

pregnancy

metronidazole is not used in the first 3 months of pregnancy unless really necessary.

Lactation period

metronidazole is excreted by breast milk but at very low doses when using Metrogyl Denta, the risk of affecting children is very low, so it can be used for breastfeeding women if necessary.

Drug interaction

Increased anticoagulant effects have been reported when Metronidazole is used with Warfarin oral anticoagulants. Metronidazole and Disulfiram are simultaneously causing confusion.

Storage

Preserving dry dry, avoiding light and frozen, temperatures below 30⁰C.

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