Metronidazole Stella 250mg tablets treat Trichomonas infection, gynecological inflammation, gum ulcer (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Metronidazole

Ingredient

Composition information	Content
Metronidazole	250mg

Uses

Indications

Metronidazole 250mg indicated treatment in the following cases:

Treatment of sensitive protozoa such as trichomonas infection, amipine infection, balantidium disease, blastocystis hominis infection, Giardia infection, dragon worm Drucunculus. Characteristic infections such as gynecological infections, acute necrotic gum ulcer, pelvic inflammatory disease and antibiotic colitis. The spectrum is wide and active on primeval animals such as amoeba, giardia and on anaerobic bacteria.

The mechanism of action of Metronidazol is not very clear. In parasites, group 5 - nitro of the drug is reduced into toxic mediators to cells. These substances are linked to the twisted structure of the DNA molecule that broke the bouncing fibers and eventually causes dead cells. The effective average concentration of metronidazol is 8microgam/ml or lower for most protozoa and sensitive bacteria. The minimum concentration of inhibition (mic) sensitive strains is about 0.5microgam/ml. A strain of bacteria when isolated is considered to be sensitive to the drug when the mic does not exceed 16 micrograms/ml.

pharmacokinetic pharmacokinetics

Distribution: Metronidazol is widely distributed in most body tissues and DJCH such as bones, bile, saliva, lung fluid, peritoneal fluid, vaginal discharge, semen, cerebrospinal fluid, liver and brain abscess. Under 20% of Metronidazole connects to plasma proteins. Metronidazol through the placenta easily. The drug is distributed into breast milk with concentrations equivalent to the concentration of the drug present in plasma.

metabolism: approximately 30-60% of metronidazol is metabolized through the liver with hydroxy, extra chain oxidation and glucuronid complex. The main metabolites are 2 - hydroxy metronidazol with anti -bacterial and protozoa activity.

Elimination: Metronidazol's sale time in plasma is about 6-8 hours in adults with normal kidney and liver function. Metronidazol's excretors in plasma are not affected by renal function changes, however, this time is longer in patients with liver function impairment. The majority of Metronidazol's oral dose is eliminated in the urine, mainly in the form of metabolites, a small amount appears in feces.

Before taking Metronidazole Stella 250mg tablets treat Trichomonas infection, gynecological inflammation, gum ulcer (2 blisters x 10 tablets)

How to use

Tablets are used by oral. The drug is taken at the same time or after meals.

Dosage

Infection Trichomonas:

The only dose of 2 g or a 7 -day treatment includes 250 mg x 3 times/day.

In addition, you should treat your partner.

AMIP:

Awesome dysentery in the intestine due to e.histolyica:

Adults: 750 mg x 3 times/day for 5-10 days.

Children: 35-50 mg/kg/day, divided into 3 times, for 5-10 days.

liver abscess due to amoeba:

Adults: 500-750 mg x 3 times/day for 5-10 days or 1.5-2.5 g x 1 time/day for 2 or 3 days.

Children: 35-50 mg/kg/day, divided into 3 times, for 5-10 days.

Balantidium disease and Blastocystis hominis infection:

750 mg, 3 times/day, for 5-10 days.

Giardia disease:

Adults: 2 g x 1 time/day, for 3 consecutive days or 250 mg x 3 times/day, for 5-7 days.

Children: 15 mg/kg/day divided into 3 times in 5-7 days.

Dracunchus dragon worm disease

Adults: 250 mg x 3 times/day or 25 mg/kg/day for 10 days.

Children: 25 mg/kg/day for 10 days. Not more than 750 mg/day (although children over 30 kg).

Anaerobic infection:

7.5 mg/kg, until 1 g, every 6 hours in about 7 days or longer.

Gynecological infections:

The only dose of 2 g or a 5-7-day treatment with 500 mg 2 times/day.

Acute gingivous gum ulcer:

250 mg x 3 times/day for 3 days; The same dose is used in acute oral infections.

antibiotic colitis:

500 mg x 3-4 times daily.

pelvic inflammatory disease:

500 mg x 2 times/day is combined with ofloxacin 400 mg 2 times/day; Continuous treatment for 14 days.

Prevention of anaerobic infection after surgery:

20-30 mg/kg/day divided into 3 times.

digestive ulcer caused by H. pylori:

500 mg x 3 times/day in combination with at least one other drug with H. pylori elimination (such as bismuth subsalicylat, amoxicillin ...) for 1-2 weeks.

liver failure:

Use caution and reduce the dose for patients with severe liver failure, especially liver brain disease. You can use 1/3 of the usual daily dose 1 time/day for these patients.

For patients with lighter liver failure: no dose reduction.

kidney failure:

No dose reduction.

or according to the doctor's instructions.

What to do when overdose?

Take a single dose of up to 15g of metronidazol that has been reported in suicide and overdose due to unintentional.

Symptoms include nausea, vomiting and loss of air conditioning. The nerve effect of convulsions and peripheral neuropathy has been reported after 5-7 days of dosage 6 - 10.4g 2 days/time.

Treatment

There is no specific antidote for the case of metronidazol overdose; Therefore, the treatment includes symptomatic treatment and support. Metronidazole is excluded through hemorrhage but is not excluded through the peritoneal fertilizer.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do if you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Metronidazole, unwanted effects (ADR) such as:

Common

Nausea, vomiting, anorexia, abdominal pain, diarrhea and mouth with annoying metal flavor.

leukopenia.

Rare:

Loss of granulocytes; Epilizer type seizures, peripheral neuropathy, headache; Diverse roses, skin rash, itching; Dark urine.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Metronidazole is contraindicated in the following cases:

Patients with hypersensitivity to Metronidazol or other nitro - imidazol derivatives or any excipients of the drug.

Caution when used

metronidazole has the effect of inhibiting alcohol Dehydrogenase and other alcohol oxidation enzymes. Disulfiram -style mild reactions such as hot face, headache, nausea, vomiting, abdominal spasms and sweating.

Should monitor clinical and experimental during treatment for more than 10 days.

Metronidazol should be used carefully and reduce the dose in patients with severe liver failure. Metronidazole should be monitored in plasma in these patients.

Use drugs for women during pregnancy and lactation

Pregnant women

Metronidazol passes the placenta and quickly penetrates the fetal circulation.

There is no adequate and well -controlled research on the use of Metronidazol in pregnant women, so it only takes medication during pregnancy when it is really necessary. Do not use medication for women in the first 3 months of pregnancy.

breastfeeding women

Metronidazol is excreted through breast milk with the concentration of drugs equivalent to the concentration found in plasma. Because tests show that Metronidazole has the potential to cause cancer in the mouse, there is a decision to stop breastfeeding or stop taking the drug, near and reminded the importance through the mother.

The effect of the drug on the ability to drive and operate machinery

Patients should be warned of the possibility of drowsiness, dizziness, confusion, hallucinations, convulsions or visual disorders and are advised not to drive or operate machinery if these symptoms occur.

Medicinal interaction

Medicinal interaction may affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

When used simultaneously with alcohol, Metronidazole can cause disulfiram reaction in some patients. Psychiatric disorder or confusion due to simultaneous use of metronidazol and disulfiram.

Metronidazole is reported to reduce the metabolism or elimination of some drugs such as Warfarin, Phenytoin, Lithi, Ciclosporin and Fluorouracil, leading to the risk of increased harmful effects. There are some evidence that phenytoin may increase the metabolism of Metronidazol.

Phenobarbital reduces the plasma metronidazol levels, the results reduce the effectiveness of Metronidazol's treatment.

cimetidine increases the plasma metronidazol levels and may increase the risk of side effects on nerves.

Storage

Leave in a dry place, avoid light, the temperature does not exceed 30 degrees C.

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