Metronizol Neo Opv vaginal gauge treats vaginitis (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Metronidazole, neomycin, nystatin

Ingredient

Composition information	Content
Metronidazole	500mg
Neomycin	65000iu
Nystatin	100000iu

Uses

Indications

Treatment of local vaginitis caused by microorganisms (such as bacteria, fungi) sensitive and vaginitis are not typical, can coordinate treatment with appropriate antibiotics.

Pharmacokology

Pharmacological group: antibacterial and anti -animal drugs in gynecological.

ATC code: G01AA51

Mechanism of action: Metronidazol is a 5-nitroimidazol conductor, with a broad spectrum on virgin animals and anaerobic bacteria. The mechanism of action of metronidazol is not very clear. In bacterial or protozoa cells, the 5-nitro group of the drug is reduced by nitroreductuctase of bacteria into toxic mediators to the cell. These substances are associated with the twisted structure of the DNA molecule to stop the copy process, eventually causing the cell to die.

Metronidazol works with most anaerobic bacteria and many types of protozoa including Entamoeba Histolytica, Trichomonas Vaginalis, Giardia Lamblia and Bantidium Coli.

Neomycin is an aminoglycosid antibiotic. The drug attaches to the ribosom 30S subunit of bacteria, thus inhibits protein synthesis and creates errors in the genetic fluid that leads to cell death. The drug has antibacterial spectrum on Gram aerobic bacteria (-) and some gram (+) bacteria. Nystatin is an antifungal drug, which has the effect of pliers and destruction of many different types of mushrooms.

The drug acts by attaching to the fungal cell membrane sterol, the result changes the absorbency of the cell membrane, causing leaking into the cell. Nystatin tolerates well even when long -term treatment and rarely cause drug resistance. The most sensitive is yeast and has a very good effect on Candida Albicans. Nystatin does not work with bacteria, protozoa and viruses.

pharmacokinetics

Metronidazol is poorly absorbed when using vaginal tablets. The amount of drugs absorbed to the peak concentration in plasma after 8 hours. Metronidazol is widely distributed. The drug appears in most tissues and body fluids including bile, breast milk, saliva, and vaginal secretions.

The drug also goes through the placenta. Less than 20% of drugs associated with plasma protein.

metronidazol is metabolized in the liver by oxidizing branch vessels and complex glucuronids. The drug is mainly eliminated in the urine. Neomycin is absorbed through wounds and inflamed or injured mucosa. The drug is quickly excreted in urine in the form of activity. The waste sale time has been reported at about 2-3 hours. Nystatin is not absorbed through the skin or mucosa when used on the spot.

Before taking Metronizol Neo Opv vaginal gauge treats vaginitis (1 blister x 10 tablets)

How to use

only for adults.

Use the vaginal lines. Dip the tablet water for about 20-30 seconds before placing it deep in the vagina and hold the position in 15 minutes after placing the drug.

Dosage

Put 1 tablet in the vagina 1-2 times daily for 10 consecutive days, coordinate more oral medication if necessary. Do not stop treating even during the menstrual cycle.

No treatment for more than 10 days and no more than 2-3 treatments in 1 year.

In addition to drugs, it is advisable to keep hygiene (especially sexual hygiene). Mandatory coordination to treat spouse (partner) although there are no symptoms.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when using overdose? However, there was a report on the Metronidazol overdose after taking a single dose of up to 12g. Symptoms may include nausea, vomiting, loss of air conditioning, and mild disorientation. In addition, the case of high doses and/or prolonged doses will have manifestations such as moderate leukopenia and peripheral sensory neuropathy.
This condition will recover after the drug is stopped.
How to handle: There is no specific antidote, mainly treating symptoms.
In case of an overdose, call the doctor immediately, or if the patient shows signs of overdose such as respiratory failure, call the emergency center 115.
What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not use twice the prescribed dose.

Side Effects

Rare, 1/10000

benign digestive symptoms such as nausea, vomiting, mouth with metal taste, anorexia, epigastric pain , diarrhea.

Seals: urticaria, itching, redness, tongue inflammation.

Hematology: Adjacent leukocytes (recovering normally when stopping the drug).

Neurology: peripheral sensory neuropathy (recovering normally when stopping the drug).

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

]

Hypersensitivity to Metronidazol, Neomycin, Nystatin or any other ingredient of the drug.

Be cautious when using

for Metronidazol

A round of treatment does not exceed 10 days and does not repeat over 2-3 times a year.

Stop treatment in case of non -tolerated drugs or allergies or dizziness, perceived disorders, loss of air conditioning.

Note that the drug can cause more severe nervous condition for patients with central neuropathy and/or peripheral level.

Do not drink alcohol or substances containing alcohol during treatment. Control the granulocytic formula in cases where patients have a history of hematological disorders or high -dose or prolonged metronizol treatments. Metronizol anchor can cause syphilis inactivation, so it can give a fake Nelson test.

For neomycin

Hypersensitivity to local antibiotics can cause sensitivity when using the body with the same type of antibiotic or causing cross -sensitivity to other antibiotics in the same group.

Treatment time should be limited because of avoiding drug resistance and superinfection.

Using drugs for women during pregnancy and lactation

Pregnancy: Neomycin and other aminoglycosides can be poisoned and systemic toxicity, so the use of drugs in pregnant women is not recommended.

Breastfeeding period: It is not known whether the drug is present in breast milk.

Should avoid using drugs in breastfeeding women.

The effect of the drug on the ability to drive and operate machinery

The drug can cause headaches, dizziness. Patients should be cautious when operating machinery, driving train, working on high and other cases.

Medicinal interaction

drug interactions may affect the activity of the drug or cause side effects.

Patients should notify the doctor or pharmacist a list of the drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Storage

Store in a dry, dry place, temperatures below 30 degrees C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.