MEXCLD 500 Imexpharm tablets treat headaches, toothache, muscle aches (10 blisters x 10 tablets)

Dosage form Tablet
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen
Indication Sore throat, fever, cold, headache, migraine, body aches
Contraindication Acute renal failure, chronic kidney failure

Ingredient

Composition information	Content
Acetaminophen	500mg

Uses

Indications

Mexcold 500 drug are indicated in the following cases:

Treatment of pains such as headaches, toothache , muscle aches, dysmenorrhea, rheumatism rheumatism . Paracetamol has an effective antipyretic analgesic effect that can replace aspirin, but it is not effective in treating inflammation. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

Paracetamol with a low dosage that affects the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding like salicylate because paracetamol does not affect the body cyclooxygenase but only affects cyclooxygenase/prostaglandin of the central nervous system.

paracetamol does not reduce body temperature in normal people. When overdose, the metabolic substance is N - Acetyl - Benzoquinonimine that is toxic to the liver.

pharmacokinetic

absorption

Paracetamol is absorbed quickly and almost completely through the digestive tract. The peak concentration of plasma is achieved within 30 - 60 minutes after drinking with treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 26% Paracetamol in the blood combined with plasma protein.

Metabolism

Paracetamol is N - hydroxylation by cytochrome P450 to form N - Acetyl - Benzoquinonimine, an intermediate reaction. This metabolic reacts with sulfhydryl (thiol) groups in glutathione and is activated. However, when taking high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathione of the liver, in that situation, its reaction to the sulfhydryl group of the liver protein increases, which can lead to liver necrosis.

Elimination

paracetamol is excreted mainly in urine. The sale time of paracetamol is 1.25 - 3 hours, can last for toxic doses or in patients with liver damage.

Before taking MEXCLD 500 Imexpharm tablets treat headaches, toothache, muscle aches (10 blisters x 10 tablets)

How to use

Oral drugs.

Do not use paracetamol to treat pain for more than 10 days in adults or more than 5 days in children, unless the doctor is instructed.

Do not use paracetamol for adults and children for high fever treatment (above 39.5 ° C), fever lasts for more than 3 days or recurrent fever, unless the doctor is indicated.

Dosage

Paracetamol content contained in Mexcold 500 tablets is not suitable for children under 11 years old.

Adults and children over 11 years old: take 1 tablet/x 3-4 times/day.

To minimize the risk of overdose, adults should not take more than 8 tablets/24 hours and children no more than 5 tablets/24 hours, unless the doctor is specified.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Gastric lavage is needed in any case, preferably within 4 hours after drinking. The main detoxification is the use of sulfhydryl compounds. The medication must be used immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcysteine is more effective when taking the drug for less than 10 hours after taking paracetamol. In addition, activated carbon or saline can be used because they have the ability to reduce paracetamol absorption.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using MexCLD 500 , you may experience unwanted effects (ADR).

Skin rash and other allergic reactions occur occasionally, usually erythema or urticaria, but sometimes worse and may be accompanied by drugs and mucosal lesions. Patients with susceptible to rare salicylate sensitive to paracetamol and related drugs. In a few individual cases, paracetamol reduces neutrophils, reduces thrombocytops and reduces all blood cells.

Uncommon, 1/1000

Ban Da.

nausea, vomiting.

Hematopoiia, Anemia .

Kidney disease, kidney toxicity when abusing for a long time.

Rare, 1/10000

Hypersensitivity reaction.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

MexCOLD 500 contraindicated in the following cases:

Sensitive to paracetamol.

Patients many times Anemia .

heart disease, lung disease, liver failure, kidney failure.

Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

Be cautious when using

paracetamol is relatively non -toxic to the dose of treatment. Sometimes there are skin reactions including lumpy, itching and urticaria. Other sensitive reactions include laryngeal edema, angioedema and anaphylactic reactions that rarely occur. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Use paracetamol carefully in patients with anemia because blue purple may not manifest clearly, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol. Should avoid or limit drinking.

Use medication carefully with people with impaired liver or kidney function.

Doctors need to warn the patient about signs of serious skin reactions such as Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

has not determined the safety of paracetamol used during pregnancy related to unwanted effects that may be available to the development of the fetus. Therefore, Paracetamol should only be used in pregnant women.

Breastfeeding period

Research in mothers using paracetamol after breastfeeding does not see unwanted effect in breastfeeding.

Medicinal interaction

long -term and high -dose paracetamol oral doses increases the anticoagulant effects of COUMARIN and indandione derivatives.

Pay attention to the ability to cause serious antipyretic in patients with paracetamol and cooling therapy.

Out of alcohol too much and long can to toxic liver toxicity.

Anti -seizure drugs (phenytoin, barbiturate, carbamazepine) cause enzyme induction in the liver microsome that increases paracetamol metabolism into toxic substances to the liver.

Collaborate with isoniazid causing increased liver toxicity.

Storage

under 30ºC, avoid moisture and light.

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