Mexcold 650 Imexpharm tablets treat headaches, toothache, muscle aches (200 tablets)

Dosage form Box of 200 tablets
Specifications Paracetamol

Ingredient

Composition information	Content
Paracetamol	650mg

Uses

indications

MEXCLD 650 drug is indicated in the following cases:

Treat the symptoms of pain such as: headache, toothache, muscle aches, dysmenorrhea, rheumatism. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

Paracetamol with a low dosage that affects the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding like when using salicylate because paracetamol does not work on the body cycloxygenase, only affects cycloxygenase/ prostaglandin of the central nervous system.

Paracetamol does not work on platelets or bleeding time. Paracetamol reduces body temperature in fever but rarely reduces body temperature in normal people. When overdose, the metabolic substance will produce n-acetyl-benzoquinoimin, toxic to liver cells.

Pharmacokinetics

absorption

Paracetamol is absorbed quickly and almost completely through the digestive tract, the peak concentration in plasma is reached within 30-60 minutes after drinking with the dose of treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Metabolism and elimination

Paracetamol is metabolized mostly in the liver and excreted mainly through urine in the form of an associate with glucuronic acid.

Sell waste time is about 1.25 - 3 hours, can last for toxic doses or patients with liver damage.

Before taking Mexcold 650 Imexpharm tablets treat headaches, toothache, muscle aches (200 tablets)

How to use

Take oral use.

Dosage

Adults and children over 11 years old:

Take 1 capsule/ time, every 4-6 hours when needed. Do not drink more than 4 g/ day.

Paracetamol content in Mexcold 650 movie tablets is not suitable for children under 11 years old.

Do not use paracetamol to treat pain for more than 10 days in adults or more than 5 days in children, unless the physician is instructed.

Do not use paracetamol for adults and children to treat high fever by themselves (above 39.5 ° C), fever lasts for more than 3 days or recurrent fever, unless it is indicated by a physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

Symptoms of overdose: Nausea, vomiting, abdominal pain, anorexia, methemoglobin - Blood leads to purple blue, mucous and nail. Children tend to create methemoglobin easier than adults after taking paracetamol.

Handling

Early diagnosis is important in the treatment of paracetamol overdose, need to wash the stomach in any case, preferably within 4 hours after drinking. The main detoxification is the use of sulfhydryl compounds.

Must take the medication immediately if less than 36 hours after taking paracetamol. Treatment with N - Acetylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. Also can use activated carbon or saline because they have the ability to reduce paracetamol absorption.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using MexCLD 650, you may experience unwanted effects (ADR).

Skin rods and other allergic reactions occur occasionally, usually erythema or urticaria, but sometimes worse and may be accompanied by drugs and mucosal lesions. Patients with susceptibility to rare salicylate sensitive to paracetamol and related drugs. In a few individual cases, paracetamol causes neutropenia, thrombocytopenia and hypoglycemia.

Uncommon, 1/1000

DA: DA

digestion: Nausea, vomiting.

Hematology: Dehydration, anemia.

kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare, ADR

Hypersensitivity reaction

In addition, Paracetamol can cause serious side effects on the skin although the incidence is not high, such as: Stevens - Johnson syndrome (SJS), toxic skin necrosis syndrome (ten) or lyell syndrome, acute overseas acne syndrome (AGEP).

Instructions for handling ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

MEXCLD 650 drug contraindicated in the following cases:

Hypersensitivity to paracetamol or any ingredients of the drug (excipients: lactose monohydrate, starch, sodium starch glycolate, Povidon K29/ 32, acic benzoic, magnesi stearat, hydroxypropyl methylcellulose (HPMC 606), Candurin Silver Fine).

Patients with anemia many times.

heart disease, lung disease, liver failure, kidney failure.

Patients with glucose deficiency - 6 - Phosphate dehydrogenase.

Caution when using

paracetamol is relatively non -toxic at the dose of treatment. Sometimes skin reactions include lumpy, itching and urticaria; Other hypersensitivity reactions include laryngeal edema, angioedema and anaphylactic reactions that rarely occur. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Use paracetamol carefully in patients with anemia before because the purple blue skin may not be clearly manifested, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking alcohol.

Use carefully with people with impaired liver or kidney function.

Doctors need to warn patients on signs of serious skin reactions such as: Stevens - Johnson syndrome (SJS), Poisoned Skin necrotic syndrome (Ten) or Lyell syndrome, acute overseas pustular syndrome (AGEP).

The ability to drive and operate machinery

The drug does not affect the ability to drive train and operate machinery.

Pregnancy

only use paracetamol for pregnant women when really necessary.

The period of breastfeeding

Research in the mother using paracetamol, has not seen unwanted effects in breastfed babies.

Be careful when using paracetamol for this object.

Drug interaction

Long -term oral high -dose Paracetamol takes slightly anticoagulant effects of COMAARIN and indandion derivatives. This effect seems to be small or not clinically important.

It is necessary to pay attention to the likelihood of serious antipyretics in patients to use simultaneously phenothiazine and cooling therapy.

Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

Anti -seizure drugs (phenytoin, barbiturat, carbamazepin): Causes the enzyme induction in the liver microsom, increases paracetamol metabolism into toxic substances to the liver.

Coordination with Isoniazid also causes increased liver toxicity.

Storage

less than 300C, avoid moisture and light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.