Meyercetam Meyer-BPC oral solution for muscle shock treatment (20 tubes x 10ml)

Dosage form Box of 20 tubes x 10ml/tube
Specifications Piracetam

Ingredient

Composition information	Content
Piracetam	333.3mg

Uses

indications

Meyercetam 333.3mg indicated treatment for muscle vibration of the cerebral cortex, regardless of the cause and should be used in combination with other anti -vibration therapy.

Pharmacokinatoda

Pharmacological group: Hung Tri (Improving metabolism of nerve cells)

ATC code: N06bx03

Piracetam has hematological effects on platelets, red blood cells, and vascular walls by increasing the deformation of red blood cells and reducing platelet aggregation, reducing red blood cells into the vascular wall and reducing capillaries.

Effects on red blood cells:

In patients with sickle cell anemia, Piracetam improves the deformation of red blood cell membrane, reduces blood viscosity and prevents the formation of red blood cells.

In open studies in healthy volunteers and in patients with Raynaud's syndrome, the doses of piracetam increased to 12 g often accompanied by reduced platelet function depending on the dose depends on the values before treatment (platelet collection tests caused by ADP, Collagen, Epinephrine and release βTG), without a significant change in the amount of platelet quantity. In these studies, Piracetam extends the bleeding time.

Effects on blood vessels:

In animal studies, piracetam inhibits vasoconstriction and loses the effect of many different vasoconstrictors. Project on direct stimulating prostacycline in the endothelial blood vessel.

In healthy volunteers, the dose of piracetam to 9.6 g has reduced the concentration of fibrinogen and the factors of Willebrand in plasma (VIII: C; VIII R: Ag; VIII R: VW) to 30-40% and increases bleeding time compared to before treatment. g/Date used for 6 months has reduced the concentration of fibrinogen and the elements of Willebrand in plasma (vill: c; v111 r: Ag; VIII R: VW (RCF)) to 30-40%, reducing the viscosity of plasma and increasing bleeding time compared to the values before treatment. Fast and almost completely after drinking. The peak concentration in plasma is achieved after 1.5 hours of medication. Piracetam's absolute bioavailability reaches nearly 100%. Peak concentration and AUC are proportional to the dose.

Distribution: Piracetam's distribution volume is 0.7 / kg. Piracetam through the barrier of the brain, the placenta and the membranes used in the kidney.

Metabolism: So far, no metabolic of Piracetam has been found.

Elimination: Piracetam is excreted almost completely through the urine. Piracetam's plasma disposal time is 5 hours.

Before taking Meyercetam Meyer-BPC oral solution for muscle shock treatment (20 tubes x 10ml)

How to use

piracetam is used by oral, can be taken or not food. Daily dose should be divided into 2-4 times. Should take medicine with a glass of water or soft drink to reduce the bitter taste of the solution.

Dosage

Start the daily dose of 7.2 g, then increase 4.8 g every 34 days until the maximum dose of the day is 24 g, divided into 2-3 times. Materials should be kept in other muscle vibration drugs when used in combination.

Depending on the clinical benefit, it may reduce the dose of these combined medications.

Once you have started treatment, piracetam should be treated continuously while the disease is still ongoing.

In patients with provincial attacks, the disease can progress well after a period of time and so every 6 months should try reducing the dose or stopping treatment.

For Piracetam, a dose of 1.2 g should be reduced every 2 days (every 3-4 days in the event of a Lance and Adams syndrome) to prevent the possibility of sudden recurrence or convulsions due to sudden suspension.

Elderly:

Should adjust the dose in the elderly with kidney function damage (see the dose adjustment for patients with renal failure below). When long -term treatment in the elderly, it is necessary to regularly evaluate the creatinine clearance coefficient for appropriate dose when needed.

Patients with renal failure:

Daily dose of the day should be suitable for the kidney function of each patient.

Refer to the table below and adjust the dose as directed. To use this dose table, it is necessary to estimate the patient's creatinine clearance coefficient (CLCR) calculated by ml/min.

Group Creatinine clearance coefficient (ml/minute)

Dosage and number of times The time

50-79 2/3 of the daily dose daily, divided 2-3 times average 30-49 1/3 of the daily daily doses, divided 2 times 30 1/6 is often used daily, once used

No dose adjustment in patients with liver failure.

Should adjust the dose when used for patients with liver and renal failure (see the dose adjustment for patients with renal failure above).

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms:
There are no additional adverse reactions related to overdose reported to Piracetam.
Management:
In case of significant overdose, the provincial level may empty the stomach by taking vomiting drugs. There is no specific antidote for Piracetam overdose.
Treatment of overdose mainly treat symptoms and may include hemorrhage.
The efficiency of the splitting machine is 50 to 60% for piracetam.
In an emergency, call the 115 emergency center immediately or go to the nearest local health station.
What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

Clinical studies designed double, verified with prices or clinical pharmacological research, in which the data on safety is available (extracted from UCB's data bank in June 1997), including more than 3,000 objects using Piracetam, regardless of treatment, daily dosage, daily dosage or characteristics of the research population.

Unwanted effects are classified according to the following frequency of use: very common> 1/10, common ≥1/100 to

Common, 1/100 ≤ ADR

Mental disorders: restlessness.

Nervous system disorders: hyperactivity.

Mental disorders: depression.

Blood disorders and lymphatic systems: coagulation disorders face.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Meyercetam 333.3mg contraindications in the following cases:

Hypersensitivity to Piracetam or any ingredients of the drug.

Caution when using

The impact on platelet gathering: Due to the impact of piracetam on platelet aggregation, should be cautious when used for patients with severe bleeding, patients at risk of bleeding such as digestive tract ulcer, potential hemostatic patients, patients with a history of stroke due to hemorrhage (CVA), patients with anti -coagulopathy, including anti -coagulation, anti -blood surgery Platelets include low -dose aspirin.

Renal failure: Piracetam is eliminated through the kidneys, so be cautious in case of renal failure (see dosage and usage).

Elderly: When long -term treatment in the elderly, it is necessary to regularly evaluate the evaluation of creatinine to adjust the appropriate dose when necessary (see the dose and usage).

Stop stopping: Sudden treatment should be avoided because it can cause muscle seizures or comprehensive seizures in some patients with muscle -shock.

The effect of drugs on driving and operating machinery

In clinical studies, at a dose of 1.6 - 15 grams per day, hyperactivity, drowsiness, stress and depression are reported more often in patients using piracetams compared to placebo groups.

There is no data on the ability to drive when using the dosage from 15 to 20 grams per day.

Be careful for patients who intend to drive or use machines while using piracetam.

Used in pregnant and lactating women

Pregnancy:

There is no enough data on the use of piracetam in pregnant women. Animal studies do not show direct or indirect effects on pregnancy, embryo or fetal development, birth or development after birth.

Piracetam passes through the placenta fence. The drug concentration in babies is about 70% to 90% of the mother's concentration.

Do not use piracetam during pregnancy unless it is really necessary, when the benefits are out of the risk and clinical status of pregnant women require treatment with piracetam.

Breastfeeding period:

Piracetam is secreted into breast milk.

Do not use piracetam while breastfeeding or no breastfeeding during piracetam treatment.

It is advisable to take into account the benefits of breastfeeding for children and the benefits of treatment for mothers when deciding not to breastfeed or do not use piracetam.

Drug interaction

Pharmacokinetic interaction:

Perfect drug interactions lead to piracetam pharmacokinetic changes are expected to be low because about 90% of piracetam dose is discharged in urine in constant form.

In the laboratory (In vitro), Piracetam does not inhibit the isomers of Cytochrome P450 in the liver CYP 1A2, 2B6, 28, 29, 2C19, 2D6, 2E1 and 4A9/11 at concentrations 142, 426 and 1422 μg/ml.

At 1422 μg/ ml concentration, observing the slightly inhibited effect on CYP 2A6 (21%) and 3A4/ 5 (11%). However, when the concentration exceeds 1422 4g/ ml, the KI value of inhibiting these two types of CYP isomers is very good. Therefore, the metabolic interaction of piracetam with other drugs is almost none.

Thyroid hormones: confused, easy to stimulate and sleep disorders have been recorded when taking this drug at the same time with the thyroid extract (T3+T4).

acenocoumarol: In a single blind study in patients with severe recurrent recurrent recurrent recurrent thrombosis, Piracetam dose of 9.6 g/day without changing the dose of Acenocoumarol needed to achieve Inr 2.5 to 3.5, but compared to the effect of acenocoumarol used alone, the addition of piracetam 9.6 g/day significantly reduces globe, reduces miniatures β-THROMBOGLOBULIN, Fibrinogen concentration and Von Willebrand elements (VIII: C; VIII: Because: Ag; VII: About: RCO) and viscosity of whole blood and plasma.

Anti -epileptic drugs: Piracetam use for 4 weeks with daily doses of 20 g does not change the peak concentration and bottom concentration of serums of anti -epileptic drugs (carbamazepin, phenytoin, phenobarbiton, valprooat) in epilepsy patients are taking stable doses.

Alcohol: Drinking alcohol at the same time does not affect the concentration of piracetam in serum and alcohol content is not changed by a 1.6 g piracetam oral dose.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

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