Meyerzadin 4mg Meyer-BPC treatment of osteoarthritis pain (10 blisters x 10 tablets)
Dosage form Box of 10 blisters x 10 tablets
Specifications Tizanidin
Ingredient
| Composition information | Content |
| Tizanidin | 4mg |
Uses
Indications
Meyerzadin 4 drugs are indicated in the following cases:
Increasing the amount of money inhibition of motor neurons at Alpha2-Aadrenergic receptors, maybe by reducing the release of stimulating amino acids and inhibiting Caeruleospinal stimulating process, leading to spasms.
There are hypotheses from a number of studies that tizanidine may have the effect after synap at stimulating aminoacid receptors.
In addition, tizanidin can also work in imidazol receptors. Tizanidine acts mainly on neurons with many synap, thus reducing the process of stimulating movement neurons on the spinal cord, which reduces muscle contraction and does not excessive muscle weakness. On experimental animals, tizanidin does not act directly on muscle - bones or nerve -muscle movement. Tizanidin also has a slight effect on SYNAP single reflexes, thus stimulating Caeruleoospinal. It is unknown the exact mechanism of Tizanidine.pharmacokinetic pharmacokinetics
tizanidin well absorbed by oral. In the condition of stomach without food, tablets and follicles are biological equivalent; But if there is food, the level and speed of absorption, the peak concentration changes. After taking tablets or follicles in the condition of gastrointestinals without food about 1 hour, the drug reaches the peak concentration in plasma and has the maximum effect, will run out of effect at about 3-6 hours; When the stomach has food, the drug reaches the peak concentration in plasma after taking 1.5 -hour tablet and after taking the cyst is 3-4 hours.
With tablets when the stomach has food, the top concentration of plasma increased by about 30%, the peak time increased by about 25 minutes and the absorption level increased by about 30%. With follicles when the stomach has food, the peak plasma concentration decreased by about 20%, the peak time increased by about 2-3 hours and the level of absorption increased by about 10%.
Drinking opened follicles and sprinkled with apple sauce will not be equivalent to biological with intact cysts in the condition of no food; The peak concentration of plasma and the area under the curve increases by about 15-20%.
Due to the initial step metabolism through the liver, oral bioavails reached about 40%. Tizanidine binds with low plasma proteins, about 30%. The drug is distributed throughout the body, the average distribution volume is 2.4 liters/kg.
About 95% of the dose is metabolized through the liver. The half -life of tizanidine is 2.5 hours, of the metabolites no longer active about 20 - 40 hours. Tizanidine excreted through the kidneys 60%, passing 20%. In the elderly, eliminated by 4 times compared to young people. If attached to renal failure (CLCR
Before taking Meyerzadin 4mg Meyer-BPC treatment of osteoarthritis pain (10 blisters x 10 tablets)
How to use
Meyerzadin 4 medicine is taken orally.
Can be taken at meals or outside meals, but must not change the way to drink, switching from drinking at meals outside the meal can be urged soon or slow down the starting time and the appearance of ADR.
Dosage
Dosage is calculated in tizanidin base. 1.14mg Tizanidine hydrochloride is equivalent to 1mg of tizanidine base.
Oral medication, has a relatively short effect, so it must be taken several times a day (3-4 times/ day) depending on the needs of the patient. Need to adjust the dose depending on the response of the patient. Do not exceed the desired treatment effect.
Adults
Muscle spasticity treatment
Normal starting dose: 2mg a single dose. After that, depending on the response of each patient, the dose may increase gradually 2mg, at least 3-4 days apart, usually up to 24mg/ day divided into 3-4 times. The maximum recommended dose is 36mg/day.
Treatment of pain caused by muscle contraction
Take 2 - 4mg/time, 3 times/day.
For kidney failure people with ClCr
The starting dose of 2 mg/time, 1 time/day, then increases until the desired effect. Each increase must not exceed 2 mg. Should increase the dose slowly 1 time/day before increasing the number of times used in the day. Must monitor kidney function.
Hepatic failure
Should avoid use; If used, the lowest starting dose must be used as possible and closely monitor ADRs (for example: hypotension).
Severe liver failure
Contraindications.
Elderly
The usual dose is like young people. The dose can be adjusted because the renal clearance can be reduced four times compared to young people.
Children
Not yet determined the safety and effectiveness of the drug.
Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.
What to do when overdose?
Handling
Use common poisoning treatments to eliminate drugs such as gastric lavage, active carbon and diuretic such as Furosemid, Manitol. At the same time treat symptoms and use support measures.
Treatment of hypotension: intravenously 0.9% sodium chloride solution 10 - 20 ml/kg, dopamine, norephedrin.
Slow heart rate: indicated using atropine; Monitor heart rate. Naloxon, often has no regression effect.
Monitor patients: Regularly monitor signs of life, monitor electrocardiograms and heart continuously; Respiratory monitoring (ventilation support) and TKTW function; Monitor the fluid balance and electrolyte.
Differences have no effect to eliminate tizanidine in the circulatory system because the drug has a large distribution (2.4 liters/kg).
What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.
Side Effects
When using Meyerzadin 4, you may experience unwanted effects (ADR).
Very common, ADR> 10/100
When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.
Warnings
Before using the drug you need to read the instructions carefully and refer to the information below.
Contraindicated
Meyerzadin 4 contraindications in the following cases:
Caution when using
on the cardiovascular system and blood pressure: The drug extends the QT range, causing slow heart rate. As well as alpha2-adrenergic labels, tizanidine may cause hypotension. Hypotension effect depends on the dose and appears after single -dose use> 2 mg. Patients may have diastolic or systolic reduction. When changing the sudden posture may increase the risk of hypotension.
Be cautious when used for patients with heart disease or in people at risk of severe or sedative effects; The risk can be minimized by careful dosage, monitoring patients on hypotension manifestations before adjusting the dose. Be careful when using tizanidine for patients who are simultaneously taking antihypertensive drugs.
Do not simultaneously tizanidine with other alpha2-adrenergic agents (for example, clonidin). Avoid simultaneous use with CYP1A2 inhibitors, as it can increase tizanidine levels in serum (causing sedation and severe hypotension). Caution should be taken when used simultaneously with TKTW and/or other antihypertensive drugs, as it can also increase sedative effects and hypotension.
tizanidine can cause liver damage, so it is very careful for people with liver failure. Aminotransferase should be monitored in the first 6 months of taking the drug (at the time of 1, 3 and 6) and then periodically monitoring depends on the clinical condition. Tizanidine must be avoided or only used to be very careful for liver function impairment.
tizanidin has a sedative effect, can cause drowsiness, need to be cautious for people who need alertness such as driving, operating machinery ... Tizanidin can cause hallucinations or paranoia, often occurring in the first 6 weeks of treatment. Be careful when used for patients with mental disorders.
Do not stop the drug suddenly, because of the risk of hypertension recurrence, fast heart rate and tone increase; Must gradually reduce the dose, especially in patients taking high doses in a long time.
On the eyes: For experimental animals, medications that cause retinal degeneration and corneal opaque. However, there is no report on these effects in clinical studies.
On people with renal failure: Use carefully the drug for people with kidney failure with Clcr
Elderly: only tizanidine uses when the benefits are considered higher than the risk due to the elderly people who clear the kidneys can decrease four times.
Children: Experience using tizanidin for children under 18 years old is very limited. So do not take medicine for children.
The ability to drive and operate machinery
tizanidine has a sedative effect, can cause drowsiness, need to be cautious for people who need alertness such as driving, operating machinery.
Pregnancy
tizanidin has not been studied on pregnant people. Should only use medication for pregnant people when really necessary.
Breastfeeding period
It has not yet been determined whether tizanidine whether or not breast milk. Tizanidine is soluble in lipids so it is likely that the drug can be through breast milk. Only use medication for breastfeeders when they have considered their benefits higher than risks.
Drug interaction
Medications that have an impact or metabolized by microsom enzymes in the liver: Reduce the clearance of tizanidine in plasma when used simultaneously with CYP1A2 inhibitors, including acyclovir, anti -rhythmic drugs (eg, amiodaron, mexiletin, propafenon, verapamil) Famotidin, fluvoxamine, fluoroquinolon drugs (e.g. ciprofloxacin, ofloxacin, nofloxacin), contraceptive oral medications, ticlopidin and zileuton. In general, avoid simultaneous use; If consideration, it is necessary to treat, be cautious when taking the drug.
tizanidine and the main metabolites of the drug are uncertain, which has an impact on the metabolism of other drugs metabolized by ISOENZYM CYP.
Medications that cause hypotension
tizanidin also lower blood pressure, so be careful when used with medications that cause hypotension, including diuretics. Do not use simultaneously with Alpha2-ADRENERGIC ADVANIZATION (e.g. Clonidin). Also be cautious when taking tizanidin along with beta-adrenergic and digoxin inhibitors because of the risk of hypotension and heart rate.
Oral contraceptives reduces the clearance of tizanidine by 50%, thus increasing tizanidin's ADR.
Alcohol and other TKTW inhibitors
The alcohol increases Tizanidin's AUC about 20%, an increase of peak concentration by 15% thus increasing Tizanidin's ADR. Tizanidin and alcohol or other TKTW inhibitors (for example, Baclofen, Dantrolen, Diazepam) in the same time, inhibit the TKTW.ciprofloxacin
Ciprofloxacin significantly increases serum and AUC concentration of tizanidin when used simultaneously, thus increasing the risk of harmful effects on the heart (including strong hypotension) and TKTW (for example: drowsiness, mental impairment). Contraindicated tizanidine simultaneously with ciprofloxacin.
Fluvoxamin
Fluvoxamine significantly increases serum concentration, half -life of excretion and auc of tizanidin when used simultaneously, thus increasing the risk of harmful effects on the heart (including hypotension) and TKTW (for example, drowsiness, mental impairment). Contraindicated tizanidine simultaneously with fluvoxamine.
Phenytoin: Tizanidine increases serum phenytoin concentration. When using these two drugs simultaneously, should monitor the phenytoin concentration to adjust the dose if needed.
acetaminophen
tizanidin extends the time to reach the peak concentration of acetaminophen 16 minutes.
Storage
In a dry place, avoid light, temperature below 30 ° C.
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