MIBEPLEN 5mg Hasan tablets treat hypertension (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Felodipine

Ingredient

Composition information	Content
Felodipine	5mg

Uses

Indications

MIBEPLEN 5 mg Hasan 3 x 10 is indicated in the following cases:

Treatment of hypertension.

Preventive treatment for stable angina. Due to the high selection on the smooth muscle of the artery, Felodipine at the dose of treatment does not work directly on the contraction or transmission of the heart muscle.

Felodipine does not work on venous smooth muscles or on sympathetic vascular control, so it does not cause hypotension.

Felodipine has anti-angina and anti-anemia effects due to improving the supply-supply-oxygen balance of the heart muscle. Felodipine increases exertion and reduces the number of angina pain in patients with stable angina.

pharmacokinetics

After drinking, Felodipine is absorbed almost completely through the digestive tract and is initially metabolized in the liver. Birth is about 15%. When taking Felodipin at meals, the drug absorption rate increases and the maximum concentration of the drug increases to 60% when the meal has high carbohydrates and fat.

About 99% of the blood felodipine is linked to protein, mainly albumin. Felodipin's waste sale time is 11-25 hours.

The drug is strongly metabolized through the liver and the output is mainly in urine in the form of inactive metabolites, the rest is excreted through feces.

Before taking MIBEPLEN 5mg Hasan tablets treat hypertension (3 blisters x 10 tablets)

How to use

MIBEPLEN should be taken in the morning, take the pills with a sufficient amount of water, not split, grind or chew. Should drink with a snack.

Dosage

Hypertension treatment

Start: 5 mg x 1 time/day.

Adjust the dose according to the response of each patient after about 2 weeks of drug use: The usual maintenance dose is 5 - 10 mg x 1 time/day.

Stable prophylaxis treatment

Adjust the dose for each patient: start 5 mg x 1 time/day for the first week, then increase to 10 mg x 1 time/day.

Adjust the dose in elderly patients or severe liver failure: The normal starting dose is 2.5 mg x 1 time/day, up to 5 mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Excessive peripheral vessels causes significant hypotension and sometimes causes slow heart rate.

Handling

When severe hypotension appears, symptomatic treatment is required.

Patients need to lie on their backs, high legs. If the heart rate is slow, it is necessary to inject intravenous atropine 0.5 - 1.0 mg. If not effective, it is necessary to increase the volume of plasma with a transmission solution such as glucose, physiological saline or dextran. The sympathetic neurological medications have a stronger effect on the receptor α-1 (isoprenalin, dopamine or noradrenalin) that can be used if all of the above measures are effective.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using MIBEPLEN, you may experience unwanted effects (ADR).

Common

headache, flushed face or hot feeling, ankle edema. These effects are common in the first weeks of medication and decrease.

Gingivitis spread in patients with mild gingivitis. Can clean with mouthwash to fix.

Rare

Nausea, fatigue, skin fertilizer, arrhythmia, suspense. Need to stop the drug immediately if this phenomenon.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

MIBEPLEN medicine is contraindicated in the following cases:

Hypersensitivity to dihydropyridin or with any other ingredient of the drug.

Acute myocardial infarction. Glucose and galactose, or lactase enzyme deficiency.

Caution when using

Precautions when using drugs for the elderly, patients with liver failure.

Stop using felodipine if after treatment, angina or angina occurs or cardiova.

Do not take medicine with grapefruit juice.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery.

Pregnancy

Contraindicated Felodipine for pregnant women.

Breastfeeding period

Medicinal interaction

Yeast inhibitors (such as alcohol, cimetidin, erythromycin, otraconazole, ketoconazole) can increase felodipine levels in plasma.

Combining felodipine with intravenous dantrolen may be very dangerous because Verapamil (another calcium choice) when combined with intravenous dancrolen leads to ventricular vibration and death in experimental animals.

enamel induction substances (such as phenytoin, carbamazepin, rifampicin, barbiturat, primidon, oxacarbazepine ...) reduce felodipine levels in plasma.

baclofen enhances felodipine hypotension effect, so the dose adjustments should be adjusted accordingly.

iTraconazole increases the risk of edema because of reducing metabolism in the liver of calcium antagonists. Need to monitor and adjust the felodipine dose during and after combined with iTraconazole.

Use Felodipine combination with sympathetic beta blockers that can cause excessive hypotension, aggravating heart failure in patients with potential or uncontrolled heart failure.

corticosteroids: reduce anti -hypertension effect of felodipine.

sedative, anti -depression drugs Imipramine enhances the hypotension as well as the risk of hypotension.

Storage

Where dry, less than 30 ° C, avoid light.

Expiry date: 36 months from the date of production.

Do not use overdue drugs indicated on the packaging.

Take the medication as directed by the doctor. Do not use the prescribed overdose. If you need more information, please consult your doctor. Notify the doctor the unwanted effects when using.

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