Mifestad 10 Stella medicine for emergency contraception for 120 hours after intercourse (1 tablet)

Dosage form 1 tablet box
Specifications Mifepristone

Ingredient

Composition informationContent
Mifepristone10mg

Uses

indications

Mifestad 10 is indicated in the following cases:

  • Emergency contraception within 120 hours after the intercourse is not protected. Progesterone receptor adjustment.

    ATC code: G03xb01

    Mifepristone is a synthetic steroid, which works as an antagonist progesterone by competing to cohesion to the receptors of endogenous progesterone. The drug associated with very high affinity on this receptor (2 to 10 times the progesterone). Mifepristone's emergency contraception mechanism includes:

    Collectic follicle inhibitors as well as inhibit the endocrine function of granular cells, so the patient will be the least likely to ovulate if used before ovulation.

    The pills break the peak in the middle of the cycle, thus inhibiting ovulation.

    If taking the drug at the end of the cycle, the drug will interrupt the endometrial support by the hormone, creating an asynchronous hole in the endometrium, which leads to degeneration and peeling of endometrium lining, thereby preventing and inhibiting pregnancy sticking to the uterus.

    At the dose of 3 to 10 mg/ kg oral, the inhibitor of endogenous progesterone and external external species (mice, rabbits and monkeys). The result will end the pregnancy in these species.

    Dynamic pharmacokinetics

    absorption

    After drinking, Mifepristone's peak concentration is achieved after 1-2 hours; Birth is about 70%.

    distribution

    About 98% Mifepristone is connected to plasma proteins, mainly with α1 - Glycoprotein acid.

    metabolism and elimination

    The drug is eliminated in 2 phases; The head phase is slow, the second phase is faster, the sale time is about 18 hours.

    Mifepristone undergo oxidation in the liver, mainly thanks to the isenzyme CYP3A4 of the Cytochrom P450 system, the metabolites are excreted into the bile and eliminate through feces. Only a small amount is detected in urine.

    • Before taking Mifestad 10 Stella medicine for emergency contraception for 120 hours after intercourse (1 tablet)

    How to use

    MIFESTAD 10 emergency contraceptive pills are used by oral.

    Dosage

    Take 1 Mifestad 10 within 120 hours after intercourse. However, the sooner the use is higher.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose? If an overdose occurs, symptoms may be renal failure.

    Treatment of overdose symptoms by supportive methods, dexethasone oral.

    What to do when forgetting 1 dose?

    Side Effects

    When using Mifestad 10, you may experience unwanted effects (ADR).

    Nervous system:

    Rare, 1/ 10,000 ≤ ADR Headache .

    Gastrointestinal disorders:

    Very common: nausea, vomiting, diarrhea (stomach - intestinal reactions related to the use of prostaglandin are often reported).

    Common, 1/100 ≤ ADR

    Skin and subcutaneous disorders:

    Uncommon, 1/1000 ≤ ADR urticaria Strange (0.2%).

    Rare, 1/ 10,000 ≤ ADR

    Very rare, ADR

    Infections and parasites:

    Common, 1/100 ≤ ADR

    Very rare, ADR vascular system:

    Uncommon, 1/1000 ≤ ADR

    Reproduction system and mammary gland:

    Very common: uterine spasm or spasticity (10 to 45%) after using prostaglandin.

    Common, 1/100 ≤ ADR

    Body:

    Rare, 1/ 10,000 ≤ ADR dizziness , chills), fever.

    Instructions on how to handle ADR

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Mifestad 10 contraindications in the following cases:

    Hypersensitivity to Mifepristone or any ingredients of the drug (excipients: lactose monohydrate, corn starch, Povidon K30, Quinolin color, Magnesi stearate, Croscarmello sodium).

    Pregnant women.

    Chronic adrenal impairment.

    Heavy asthma is not controlled.

    kidney failure or liver failure.

    Genetic porphyrin metabolism disorders.

    Be cautious when using

    There is no research on special patient groups such as kidney failure, liver failure and malnutrition. So Mifepristone does not recommend for these patients.

    Bleeding: Patients must be warned that prolonged vaginal bleeding may be worse (on average 12 days or more when using Mifestad 10). However, this phenomenon is not necessarily a complete pregnancy.

    Infections: Very rare but there has been reports on cases of shock due to serious toxin or fatal infections due to pathogens such as Clostridium Sodellii that causes endometritis or Escherichia coli, fever or no other obvious bacterial symptoms after using Mifepristone.

    Emergency contraception is a temporary measure, only used in emergency and cannot be replaced for regular contraception. Those who use emergency contraception several times should consider using long -term contraception.

    Emergency contraception method cannot achieve the desired effect in any case. If not sure about the time of unpollable intercourse or if a woman has an unpopular intercourse for more than 120 hours in the same menstrual cycle, they can become pregnant. Therefore, treatment with Mifepristone 10 mg after the second intercourse may not have the effect of contraception. If the menstrual period occurs more than 5 days later, or abnormal bleeding on the expected menstrual dates or suspected pregnancy for any other reason, the patient must determine not to get pregnant.

    Unsafe intercourse after treatment may increase the risk of unwanted pregnancy.

    Do not treat repeated in the same period because menstrual disorders can cause menstrual disorders.

    Should be used carefully in little asthma patients with little serious or chronic pulmonary obstruction, hemorrhage, cardiovascular disease or related risk factors, anemia .

    Be careful in patients being treated for long -term with corticosteroids; Corticosteroid may be used if the adrenal glands are suspected.

    also need to be cautious in patients who are taking anticoagulants because they can increase the risk of severe bleeding.

    Mifestad 10 contains lactose excipients. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose - galactose.

    The ability to drive and operate machinery

    Mifestad 10 emergency contraceptive pills affect the ability to drive or operate machinery?

    The drug can cause unwanted effects such as headache, dizziness and hypotension. If these unwanted effects occur, patients should not drive or operate machinery.

    Pregnancy

    Mifestad 10 emergency contraceptive pills can be used for pregnant women?

    Do not use Mifepristone for pregnant women and the drug has no abortion effect.

    10 mg is not sufficient to cause miscarriage but cannot exclude hemorrhage that may occur in several cases if women are pregnant.

    Breastfeeding period

    Mifestad Emergency Contraceptive Pills 10mg can be used for nursing women?

    Theory of Mifepristone can be excreted through breast milk. However, there is no complete research when using drugs in nursing women. Do not recommend using drugs during breastfeeding.

    Drug interaction

    drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

    Do not use aspirin and NSAIDs with Mifepristone because in theory, there is a risk of Prostaglandin synthetic inhibitors that can change the effects of Mifepristone.

    Cavalry of the drug: Due to no studies on the correspondence of the drug, not mixing this drug with other drugs.

    Storage

    In closed packaging, dry place. The temperature does not exceed 30 ° C.

    Other drugs

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