Migomik Hasan medicine treats steady circulation disorders, migraine (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Dihydroergotamin

Ingredient

Composition information	Content
Dihydroergotamin	3mg

Uses

Indications

Standing circulating disorders, reducing primary or secondary blood pressure, symptoms such as dizziness or prolonged fatigue.

Treatment for batches to prevent migraine and headache headaches.

Pharmacokology

dihydroergotamine is ergotamine (alcaloid of chicken spurs) is hydrogenated, which has complex pharmacological effects. The drug has a affinity for both alpha-adrenegic receptors and serotonergic receptors, thus both stimulating effects (treatment dose) and inhibited effect (high dose).

In decreased vertical blood pressure: Dihydrorogotamine has a selective effect that causes vascular vasoconstriction of containers (veins, veins), almost no effect on bumper (arteries, arteries). Increasing intravenous tone leads to bleeding, so it will prevent too much blood in the vein.

In migraine: At first, the drug has a mirroring effect in plasma serotonin. Then, due to the stimulation of serotonin, it against the tone of the outer circuit system, especially the carotid circuit system was relaxed. To treat migraines, dihydroergotamine should be injured (fast effect). To prevent migraine, it is advisable to take a long drink, to stabilize the external vascular system.

Dynamic pharmacokinetics

absorption: After oral, about 30% of the drug is absorbed. The drug is quickly absorbed (half-life 10-20 minutes) and the maximum plasma concentration is achieved after 1 hour. Anti -vascular headache effect depends on the time of medication after appearing headache.

Distribution: dihydrorogotamin binds to 93%plasma proteins. The apparent distribution volume is 30 liters/kg.

Metabolism: Dihydrorogotamine metabolized mainly in the liver into metabolic substances with activity 8'-β-hygrydihydrohydrooRoERGOTAMIN. The plasma concentration of this metabolic substance is higher than dihydroergotamine. The oxidation process produces 8 ', 10'-dihydroxydihihydroergotamine is also active. Other metabolites are also formed.

Elimination: The body clearance is about 1.5 liters/minute, reflecting the drugs that are cleared mainly through the liver. Elimination mainly through molasses into feces. Eliminate through the urine both initial and metabolite 1 - 3% if used. Selling time is about 10 hours.

Before taking Migomik Hasan medicine treats steady circulation disorders, migraine (3 blisters x 10 tablets)

How to use

Take oral, drink right before meals. To have the most effective headache due to vessel headache, the medication must be used immediately at the beginning of the first symptom (in the million dong period: if there is a symptom or at the beginning of the pain). Use

often drink dihydroergotamin mesylat 3 mg x 3 times/day.

What do

do when overdose? Overdose may cause signs and symptoms of fungal poisoning: loss of sensation, throbbing, pain and purple blue, accompanied by loss of vessels or weak pulse; Difficulty breathing, increased and/ or reducing blood pressure, confusion, delusion, convulsions and coma; Nausea, vomiting with levels and abdominal pain. Because of the chronic nature of vascular headache, it is necessary to recommend that patients should not use the recommended overdose.

Side Effects

Common: headache; nausea, vomiting; Foot cramps, aches and pains.

Less: dizziness, anxiety, a lot of sweating; diarrhea; Ban, flushed; shortness of breath; vascular spasms, hypertension; Perception, fibrosis and peritoneal (prolonged treatment).

Rare: myocardial infarction and stroke.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Patients with hypersensitivity to mushroom alcaloid.

Patients with vascular spasms such as peripheral artery disease, coronary artery (especially unstable angina), blood infections, shock, vascular surgery, uncontrolled hypertension, severe liver/kidney failure.

Pregnant and lactating women (see the use of drugs for pregnant and lactating women).

Coordinate with vasoconstrictors (because it can cause excessive hypertension).

Be cautious when used

dihydroergotamine is like other chicken spurs mushrooms, which can cause vascular spasms, including angina but less common. This effect is usually related to the dose. However, some patients may be sensitive to drugs. Because prolonged vascular spasm can cause necrosis or death, if there are signs and symptoms of vasoconstriction (muscle pain, loss of sensation, cold head, pale, purple toes, arms), angina or abnormal syndrome such as ischemia must be stopped immediately.

should only use dihydroergotamine for vascular migraine; There is no effect in other headaches and non -painful drugs.

When taking the drug, patients should immediately notify the doctor when there are the following signs: loss of sensation or pain of the tip of the toe, arms, arm muscles, lower leg muscles, lower muscle weakness, chest pain, slow or fast heartbeat, swelling, itching.

The effect of the drug on the ability to drive and operate machinery

Patients with a history of dizziness or central neurological disorders should not drive, operate machinery.

Use drugs for women during pregnancy and lactation

Small amount of dihydroergotamine through the placenta, although not toxic to the fetus but causes uterine vascular spasms, increases uterine muscle tone, reduces uterine and placental blood flow, prevents pregnancy from developing. Contraindications for pregnant women.

Mushrooms inhibit the Prolactin inhibitors. Dihydroergotamin is excreted into breast milk, which can cause vomiting, diarrhea, weak pulse, unstable blood pressure for children. Therefore, no breastfeeding while using dihydroergotamin.

Interactive drug

with vasoconstrictor drugs: Do not use simultaneously dihydrorogotamine with vasoconstriction or sympathetic drugs because it will cause excessive hypertension.

With beta blockers: The spurs of the chicken causes vascular shrinkage. Beta blockers are blocked with beta 2 so it also causes vascular contractions and reduces blood flow due to cardiac flow.

With nicotine: Nicotine can cause vasoconstriction in some patients that increase the tendency to cause ischemic of chicken fungus.

With macrolid antibiotics (erythromycin, josamycin, ponsinomycin, triacetyloleandomycin): When used in combination, the poisoning of chicken fungus increases rapidly.

With glyceryltrinitrate: dihydroergotamine against vasodilation effects of glyceryltrinitrate (nitroglycerin).

Mushrooms + Methysergid: Increases the risk of artery spasms mainly in some patients.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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