Milgamma n Solupharm injection solution for neuritis (5 tubes x 2ml)

Dosage form Box of 5 tubes x 2ml
Specifications Thiamin, pyridoxine, cyanocobalamin

Ingredient

Composition informationContent
Thiamin100mg
Pyridoxine100mg
Cyanocobalamin1mg

Uses

indications

Milgamma n drugs are indicated in the following cases:

  • Neurological diseases have different origins. Learning and nerves caused by the shortage of vitamins B1, B6 and B12 that when treated with inappropriate oral treatment.

    They are not only used to treat diseases due to vitamin deficiency, but with high doses, it also has the effect of reducing pain, anti -allergy and increasing circulation, these are the effects that can be achieved with Milgamma n.

    Vitamin B1 is also indicated as an anti -inflammatory vitamin. In the form of flower phosphoryl (TPP) such as cocarboxylase, vitamin B1 regulates carbohydrate decomposition and is used against metabolic acidosis.

    Vitamin B6 regulates protein, fat and carbohydrate decomposition. Its neuropathy effect is used in the case of Inh treatment to avoid neuritis. Symptoms of foreign tapes decrease by the effect of vitamin B6 on the brain body.

    Vitamin B12 is an essential substance for cell metabolism, normal hematopoietic and function of the nervous system. It catalyzes nucleic acid synthesis and new cell nuclear structure. In high doses, vitamin B12 has analgesic, anti -allergy and increased circulatory.

    Due to the supplementary components, the combination of vitamins in Milgamma N is effective and well tolerated, used within wide range, beyond the treatment of acute and chronic neurological diseases.

    Dynamic pharmacokinetics

    Thiamine is absorbed from the intestine by the positive transportation process. The absorption limit 8 - 15 mg daily. About 1 mg of thiamine is decomposed in the body daily. Any excess thiamine is excreted in the urine.

    Test Tryptophan stress test is suitable for determining vitamin B6 status. After taking 0.1 g L - Tryptophan for each kilogram of body weight, excreting xanthurenic acid normally less than 30 mg every 24 hours. Higher excretion of xanthurenic acid shows that vitamin B6 deficiency.

    pyridoxin, pyridoxal and pyridoxamine are absorbed very quickly, phosphorylation and oxidation into pyridoxal - phosphate (PALP) and pyridoxal. The excretory product is acid 4 - pyridoxic.

    Vitamin B12 releases from food during stomach digestion with intrinsic factors (IF).

    glycoprotein is now formed to form cells into stomach mucosa. The complex of Vitamin B12 - IF is resistant to protein enzyme and enters the peripheral ileum, where it is linked to specific receptors, thereby ensuring vitamins are absorbed. Vitamin B12 is transported through the mucosa during capillary circulation, and linked to Transcobalamin transport protein. This complex is quickly absorbed by the liver, bone marrow and other reproductive cells. Absorption is hindered by patients who lack internal factors, patients with malabsorption or changes in the small intestine, after gastric cutting or in the case of creating autoimmune antibodies. As a rule, only 1.5 - 3.5 µg of vitamin B12 is absorbed from the oral diet.

    Vitamin B12 is excreted in bile according to the liver -intestinal cycle. Vitamin B12 is transported through the placenta.

    • Before taking Milgamma n Solupharm injection solution for neuritis (5 tubes x 2ml)

    How to use

    Use intramuscularly.

    Injected drugs are injected into the muscles (IM).

    Dosage

    To quickly achieve high concentrations in the blood in case of severe illness and acute pain, from the beginning of an injection every day (2 ml). After the acute phase has been relieved, and in the case of few serious disorders, injecting 2-3 times a week.

    Recommendations for weekly treatment monitoring.

    Try to switch to oral treatment at the earliest time.

    Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

    What to do when overdose?

    What to do when forgetting a dose?

    Side Effects

    When using Milgamma n you may experience unwanted effects (ADR).

    Any assessment of side effects is always based on the following frequency parameters:

    Very popular: ≥ 1/10 (≥ 10%).

    Popular: ≥ 1/100 to

    Occasionally: ≥ 1/1,000 to

    Rare: ≥ 1/10,000 to

    Very rare:

    immune system disorders

  • Rare: Hypersensitivity reactions (such as skin rash, respiratory failure, shock, angioedema).
  • There may also be cases of hypersensitivity reactions caused by benzyl alcohol.

    • Nervous system disorders

  • Unknown frequency: dizziness, loss of attention.

    • Heart disorders

  • Very rare: tachycardia.
  • Unknown frequency: slow heart rate, heart chaos.

    • Gastrointestinal disorders

  • Unknown frequency: vomiting.

    • Skin and subcutaneous tissue disorders

  • Very rare: sweating a lot, acne, itching and urticaria.

    • Muscle, bone and connective tissue disorders

  • Unknown frequency: cramps.

    • conventional disorders and at the injection site

  • Unknown frequency: Systemic reactions may be due to rapid flow (unintentional intravenous injection, tissue injections with high blood supply) or overdose.

    • Instructions on how to handle ADR.

    When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

    Warnings

    Before using the drug you need to read the instructions carefully and refer to the information below.

    Contraindicated

    Milgamma n drugs in the following cases:

  • Hypersensitivity to the active ingredients or with any other ingredients.

    • Be cautious when used

    Milgamma n is only intramuscularly (IM) and not intravenously (IV) into the bloodstream. Any case of intravenous injection must be monitored by a doctor or in the condition of five hospitals, depending on the severity of the symptoms.

    The drug can cause neurological disorders if used for more than six months.

    Milgamma N contains sodium, but less than 1 mmol (23 mg) sodium in each dose unit (2 ml).

    Children and elderly

    Milgamma N is not used to treat children under 12 years old because it contains benzyl aleohol and high doses of vitamins in Milgamma n.

    No special recommendations in the elderly.

    The ability to drive and operate machinery

    No report.

    Pregnancy

    Do not use vitamin B6 with daily dose of up to 25 mg in pregnant and lactating women. This product contains 100 mg/tube 2 ml, which is why the drug is not used in these cases.

    Lactation period

    Do not use vitamin B6 with daily dose of up to 25 mg in pregnant and lactating women. This product contains 100 mg/tube 2 ml, which is why the drug is not used in these cases.

    Drug interaction

    Thiamine is completely decomposed by solutions containing sulfit. Other vitamins may be inactivated in the presence of decomposition products of vitamin B1. The dose of vitamin B6 can reduce the effectiveness of L - Dopa. In addition, there is an interaction with Inh, D - penicillamine and cycloserine.

    Storage

    Store in the refrigerator (2 ° C to 8 ° C). Avoid light and hot.

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    Disclaimer

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    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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