Mirgy hard capsules 100mg Getz treat neuropathy, epilepsy (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Gabapentin

Ingredient

Composition information	Content
Gabapentin	100mg

Uses

indications

Mirgy drug is indicated in the following cases:

Treatment of many types of neurological pain in adults including: Hau Herpes Neurology; peripheral diabetes; Neurological pain triangle. Especially on the brain tissue like the new cortex and hilly area. Although the exact mechanism of the central nervous and anti -convulsed activity of the drug has not been fully understood, maybe the drug is activated through the peptide bonding locations (receptor).

Pharmacokinetics

absorption

Gabapentin is absorbed through the gastrointestinal tract by saturated mechanism. Gabapentin's bioavailability is not the same as the dose. The absolute bioavailability of oral 300 mg is approximately 60%. At the dose of 300 mg, 400 mg of bioavailability of gabapentin is unchanged when using multiple doses. Food does not affect the level and speed of pharmacokinetics of Gabapentin.

Distribution

less than 3% of gabapentin is attached to plasma proteins. Gabapentin can be breast milk.

Metabolism and elimination

Gabapentin is eliminated from the circulatory system through the renal in a constant form. Gabapentin's exhaust time in plasma does not depend on the dose and averages about 5-7 hours. The ratio of gabapentin elimination is constant, elimination from plasma, the renal elimination of gabapentin directly proportional directly with creatinine clearance.

Before taking Mirgy hard capsules 100mg Getz treat neuropathy, epilepsy (1 blister x 10 tablets)

How to use

oral. Drink with or not with food.

Dosage

Mirgy (Gabapentin) is gradually decided to finally achieve an effective dose. The treatment progressed rapidly and completely for a few days. Dosage should be divided into 3 times with a distance of not exceeding 12 hours. Mirgy (Gabapentin) can be taken with or not with food.

Neurological pain (adults over 18 years old)

The starting dose of Mirgy (Gabapentin) can be classified in the following table. After that, the dose may increase to 300 mg/day until the maximum dose must not exceed 1800 mg/day, divided into 3 times. There is no need to be divided into equal doses.

Day 1

Monday

3rd day

300 mg

1 time/day

2 times/day

3 times/day

epilepsy

Adults and children over 12 years old

Can be used 300 mg x 3 times/day on the first day or use according to the following tutorial:

Day 1

Monday

3rd day

300 mg

1 time/day

2 times/day

3 times/day

Higher doses until a maximum of 2400 mg/day may require some patients.

Children from 3 to 12 years old

Can use Mirgy (Gabapentin) in the form of oral solution of 250 mg/5 ml to treat children with weight

The recommended starting dose is 10 - 15 mg/kg, increasing after about 3 days with a dose of about 40 mg/kg/day for children 3-4 years or 25 - 35 mg/kg/day for children 5 years old or older, divided into several times (3 times/day).

The maintenance dose is recommended depending on the body weight presented in the following table:

body weight (kg)

Daily dose (mg/day)

17 - 25

600

26 - 36

900

37 - 50

1200

51 - 72

1800

Patients with renal failure

It is necessary to adjust the dose for patients with renal impairment or epilepsy.

Creatinine clearance (ml/minute)

Total daily dose A (mg/day)

900 - 1800 divided into 3 times/day

50 - 79

600 - 1200 divided into 3 times/day

30 - 49 300 - 600 divided into 3 times/day

15 - 29

300 divided into 3 times/day

300 b

Dosage for treatment for patients with normal renal function (creatinine clearance> 80 ml/minute) between 900 - 1800 mg/day. Dosage must be reduced for patients with renal function (creatinine clearance

b is used by day.

Patients who are hemolysis

The recommended dose is 300 - 400 mg, then reduced to 200 - 300 mg every 4 hours of blood decomposition.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose? Signs of acute poisoning in animals include: loss of air conditioning, heavy breathing, eyelid prolapse, pain relief and agitation.

Excessive oral doses of gabapentin when used up to 49 g have been recorded, overdose symptoms: Song, stuttering, drowsiness, coma and diarrhea. All patients recover after supportive treatment.

Gabapentin can be eliminated through hemorrhage. Although there have been some cases of overdose treatment without using hemolytic methods. This procedure is indicated depending on the clinical condition of the patient, or in patients with signs of severe renal failure.

What to do when you forget 1 dose? If it is nearly time to take the next dose, skip the forgotten dose and take medicine at the next recommended dose. Do not take double dose to compensate for the forgotten dose.

Side Effects

When using Mirgy medicine , you may experience unwanted effects (ADR).

Common: fatigue, weight gain, back pain, headache, abdominal pain, diarrhea, flatulence, hyperglycemia, peripheral edema, vasodilation, indigestion, dry mouth, constipation , appetite, leukopenia, muscle pain, fracture, rhinitis , sore throat, bronchitis, cough, cough, otitis media /or vomiting, drowsiness, dizziness, loss of air conditioning, eye seizures, trembling, nervous tension, speech, forgetfulness, depression, abnormal thoughts, muscle jerky, hostile acts, easy to change emotions, reduce sensation, and increase movement.

Using Gabapentin in children 3 - 12 years old with epilepsy can occur side effects on the central nervous system. The most significant side effects can be divided into the following groups:

Easy to change emotions (Priority issues).

hostile behavior, including aggressive attitudes.

In patients treated with gabapentin, the above side effects occur mild or medium.

Instructions on how to handle ADR

Notice the doctor the side effects encountered when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Mirgy drugs contraindicated in the following cases:

Patients with hypersensitivity to gabapentin or any ingredients of the drug.

Children under 3 years old.

Be cautious when using

should not stop using Gabapentin suddenly because there is the ability to increase the frequency of seizures.

Be cautious for patients with a history of mental illness.

Do not view gabapentin as a treatment for no seizures and the drug can worsen seizures in some patients. Therefore, it is necessary to be cautious when using gabapentin in patients with mixed epilepsy disorders, including no seizures.

The ability to drive and operate machinery

gabapentin can cause drowsiness, dizziness, or other relevant symptoms and can affect the mild, average to drive and operate machinery. Patients should not drive and operate special complex machines in the early stages of treatment and after increasing dose.

Pregnancy

Because there is no complete testing of pregnant women, using drugs only in pregnant women when they have considered the benefits and potential risks for the fetus.

Breastfeeding period

gabapentin excreted breast milk through oral route. Babies can withstand a maximum dose of about 1 mg of gabapentin/kg/day. Because the impact of the drug on newborn babies is not well known, breastfeeding mothers should only use gabapentin when the benefits of treatment are higher than the risk may occur.

Interactive drug

phenytoin, valproic acid, carbamazepin or phenobarbiton

There is no interaction when combining gabapentin treatment with the above drugs. Gabapentin's pharmacokinetics in a stable state are the same in healthy people with epilepsy using anti -epilepsy.

morphine

Simultaneous treatment with morphine in some patients with cards increases gabapentin levels. Patients should be carefully monitored by signs of central neurasthenia such as drowsiness and at the same time the dose of gabapentin as well as morphine must be reduced properly.

antacids

Gabapentin's bioavailability drops to about 24% when used simultaneously with antacids containing aluminum and magnesium. Gabapentin should be taken about two hours after taking any antacids.

Storage

Store in a cool place, temperatures below 30 ° C, avoiding light.

To be out of reach of children.

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