Misoprostol Stella 200mcg tablets reduce the risk of stomach ulcers (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Misoprostol

Ingredient

Composition information	Content
Misoprostol	200mcg

Uses

Indications

Misoprotosol Stella 200mcg drug is used to:

Reduce the risk of stomach ulcers caused by nonsteroidal anti -inflammatory drugs in patients at high risk of progressive stomach ulcer and complications from these ulcers. Reproductive health care ”issued together with the Minister of Health's Decision No. 4128/QD-BYT of July 29, 2016. Misoprostol protects the gastric - duodenal mucosa due to the inhibition of basic acid secretion, acid secretion caused by irritation and acid secretion at night and by reducing the volume of gastric juice, protein decomposition of gastric juice, increasing secretion of mucus and bicarbonate.

pharmacokinetic

Misoprostol is absorbed and metabolized quickly into Misoprostol acid, which is active after drinking. The peak concentration of plasma of Misoprostol acid is achieved after about 15 - 30 minutes.

Food reduces the speed but does not affect the level of absorption. Misoprostol acid is metabolized by oxidation in some organs and is excreted mostly through urine. The final waste time in plasma is about 20 - 40 minutes.

Before taking Misoprostol Stella 200mcg tablets reduce the risk of stomach ulcers (3 blisters x 10 tablets)

How to use

Misoprotosol Stella 200mcg drugs are used by oral.

To limit diarrhea caused by Misoprostol, should break down the dose, take after meals and before going to bed, avoid use with antacids containing magnesi or other laxative properties.

Dosage

Preventing ulcerative nsaids

Misoprostol dose for adults is 200mcg x 4 times/day. However, reducing the dose may reduce the effectiveness.

Misoprostol dose is 100mcg or 200mcg x 4 times/day for 8 weeks for adults.

duodenum ulcer

Misoprostol dose is 100mcg or 200mcg x 4 times/day or 400 mcg x 2 times/day for 4-8 weeks for adults.

Dose for people who fail and elderly

No need to reduce the dose of Misoprostol for patients with renal failure or the elderly, however, if the patient cannot tolerate the normal dose, the dose may be reduced.

Mitepriston support in abortion

In accordance with the "National Guide on Reproductive Health Care Services" issued together with the Minister of Health's Decision No. 4128/QD-BYT dated July 29, 2016.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? When an overdose occurs, it is mainly to treat symptoms and use support.

In clinical trials, the patient tolerates 1200mcg (6 capsules) per day for 3 months without significant side effects.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Misoprotosol Stella 200mcg, you may experience unwanted effects (ADR).

The most unwanted effect of Misoprostol is diarrhea.

Other effects on the digestive system include abdominal pain, indigestion, flatulence, nausea and vomiting.

Increased uterine spasm and abnormal vaginal bleeding (menstrual bleeding, mid -term bleeding) have been reported.

Other side effects include:

Skin rash;

headache;

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Misoprotosol stella 200mcg drugs are contraindicated in the following cases:

Misoprostol contraindicated for pregnant women and intended to get pregnant because of increasing tone and uterine contractions in pregnant women, which can cause partial or complete miscarriage. Used for pregnant women may be related to teratogen.

Patients with misoprostol allergies or other prostaglandin or any ingredients of the drug.

For Mifepriston support for abortion

Absolute contraindications:

2 -leaf valve stenosis, embolism and clogged history.

Adrenal pathology.

Disorders of coagulation, anticoagulant use.

Anemia (severe and medium).

Certain diagnosis or suspicion of ectopic pregnancy.

Pregnant at the old surgical scar in the uterus.

Salted vegetables.

Relative contraindications:

Treatment of systemic corticosteroids for a long time.

Hypertension.

Being infected with acute genital tract (need to be treated).

Genital deformities (only made at the central level).

There is an uterine surgical scar to be cautious: reduce the dose of Misoprostol and increase the time gap between drug use (only made at the provincial and central gynecological specialist hospital).

Precautions when used

Because of the serious harmful effect on the heart has been reported to Misoprostol, caution should be used with patients with a history of cardiovascular disease.

Misoprostol can seriously cause inflammation and cause severe diarrhea for patients with bowelitis, so it is cautious when taking the drug for these patients and carefully monitoring. Rarely occurs dehydration caused by secondary diarrhea caused by Misoprostol, but carefully monitor patients who are prone to dehydration or patients may suffer from serious consequences.

Self-use of drugs for abortion can be life-threatening, proposing to follow the instructions of the doctor for treatment and national guidance on reproductive health care services prescribed in the Minister of Health's Decision No. 4128/QD-BYT dated July 29, 2016.

The ability to drive and operate machinery

Misoprostol can cause dizziness. Patients need to be cautious when driving or operating machinery.

Pregnancy

Misoprostol has the effect of causing miscarriage so it is dangerous for the fetus when indicated for pregnant women.

Therefore, Misoprostol should not be indicated for pregnant women or women who may be pregnant when the possibility of pregnancy has been excluded and started an effective method of contraception.

Breastfeeding period

It is unknown whether the metabolic is the activity of Misoprostol is excreted through breast milk, so Misoprostol should not be used during breastfeeding.

Medicinal interaction

Interaction of drugs

Food and antacids reduces the absorption rate of Misoprostol, causing delays and reducing the peak concentration in the plasma of Misoprostol acid, the active metabolites of the drug.

Antacids and food also reduces the oral bioavailability of Misoprostol, but does not have clinical significance because of the effect of protecting the stomach mucosa - the intestines of Misoprostol in place better than the whole body.

Magnesi antacids also increase the risk of Misoprostol's diarrhea. Therefore, if used with antacids should replace antacids containing magnesi or other laxative antacids with constipation antacids (such as aluminum antacids).

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Store in closed packaging, dry place. The temperature does not exceed 30 ° C.

Other drugs

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