Mixing powder of ACC 200 Lindo mucus in bronchial-chronic and chronic bronchi (50 packs)

Dosage form Powder mixed oral solution
Specifications Box of 50 packs
Ingredient Acetylcysteine

Ingredient

Composition information	Content
Acetylcysteine	200mg

Uses

Indications

ACC 200 drugs are indicated in the following cases: Mucus in acute and chronic bronchial diseases accompanied by mucus secretion.

Pharmacokinatus

Therapy group: Mucus pills.

ATC code: R05cb01.

Acetylcysteine is a derivative of amino acid, cysteine. The effect of acetylcysteine is to reduce the slope of phlegm and reduce mucus secretion in the airway. It is still arguing about the cutting of disulphide bridges between mycopolysaccharide wires and the drug has the effect of cutting polymers in the DNA chain (in mucus). Based on these mechanisms, the viscosity of the mucus is reduced.

A alternative mechanism of acetylcystein is based on its ability to react with the SH group to link with chemical and detoxifying roots in this way.

Moreover, Acetylcysteine contributes to the synthesis of glutahion, which is an important substance in detoxification. What explains the anti -toxic effect on the poisoning paracetamol .

pharmacokinetic

absorption

After oral use, most acetylcystein is absorbed quickly and metabolizes the liver into cysteine, an active metabolite, as well as diacetylcystein, cystin and other disulphids.

Due to a strong step metabolism, the oral bioavailability of acetylcysteine is very low (approximately 10%). In humans, the maximum concentration in plasma is achieved after 1-3 hours with the maximum concentration in the plasma of cysteine metabolites in approximately 2μmol/l. The link between acetylcysteine and protein is determined by about 50%.

Metabolism

Acetylcystein and its metabolites exist in three different forms in the internal organs: part of the free form, part of the binding with protein through unstable disulphid bonds and part of the combined amino acid. Acetylcysteine is excreted mostly in the form of non -active metabolites (inorganic sulphate, diacetylcysteine) through the kidney. Acetylcysteine plasma is approximately 1 hour and mainly determined by rapid metabolism in the liver. Therefore, in people with impaired liver function, the sale time in plasma can be extended to 8 hours.

Elimination

Acetylcystein's pharmacokinetics research shows the distribution of 0.57L/kg (general) or 0.58L/kg.

Selling time after intravenous injection is 30-40 minutes when excreted by 3 -phase dynamics (Alpha, Beta and the end phase of gamma). Acetylcystein passes the placenta and is found in the umbilical cord blood. There is no information related to the excretion of breast milk.

There is no information on influencing Acetylcystein's behavior to the human brain barrier.

Before taking Mixing powder of ACC 200 Lindo mucus in bronchial-chronic and chronic bronchi (50 packs)

How to use

The drug can be dissolved in water and drink after meals. Bronchitis is full and increases mucus secretion, which needs to use acc 200 for a longer time to achieve preventive and anti -infection effects.

Dosage

If there is no other instruction of the doctor, the usual dose is as follows:

Treatment of mucus

Adults and teenagers over 14 years old: 1 pack x 2-3 times/day (400 - 600mg acetylcystein/day).

Mucus secretion disease

Children over 6 years old: 1 pack x 3 times/day (600mg acetylcystein/day). Patients with increased secretion of mucus with body weight over 30kg may take the dose up to 800mg/day, if necessary. No serious side effects in volunteers have been treated at a dose of 11.6g of Acetylcystein/day for more than 3 months. Oral dose up to 500mg Acetylcystein/kg weight are tolerated without symptoms of poisoning.

Symptoms of overdose canxicity may occur digestive tract irritation (nausea, vomiting, diarrhea ). Babies are at risk of increased secretion.

Treatment of poisoning to treat symptoms if necessary.

What to do when forgetting the dose?

Side Effects

The evaluation of unwanted effects is based on the following frequency information:

Very common (≥ 1/10).

Common (≥ 1/100 to

immune system disorders

Less: Hypersensitivity.

Less: headache.

Disorders of ears and mesmerizing

Less: tinnitus.

cardiovascular disorders

Uncommon: tachycardia.

vascular disorders

Uncommon: Hypotension.

Very rare: Bleeding.

Rare: Difficulty breathing, bronchospasm.

Disorders of the digestive system

Less: Nausea, vomiting, diarrhea, abdominal pain.

Rare: indigestion.

Uncommon: urticaria, rash, angioedema, itching, rash.

Common disorders and at the position of drugs

Uncommon: Fever.

Unknown: Facial edema. So far the clinical relationship has not been clarified.

Notify the doctor with unwanted effects when using the drug.

Warnings

]

Hypersensitivity to acetylcystein or any ingredients of the drug.

Be cautious when taking the drug

It should be noted when you have a history or have a bronchial asthma or have a stomach or intestinal ulcer.

The use of acetylcysteine, especially in early treatment, can lead to a liquid formation thus increasing the volume of the bronchi. If the patient does not know how to spit (spit out), it is necessary to apply appropriate measures (such as sputum suction or water reduction).

Very rarely report on serious side effects such as Stevens-Johnson and Lyell syndrome related to the use of acetylcysteine. If you have recently seen changes in the skin and mucosa, please consult a doctor and stop using acetylcystein.

Driving and operating machinery

No special attention when driving and operating machinery.

Pregnancy

There is not enough data for using acetylcysteine for pregnant women. Research on experimental animals does not indicate harmful or indirect effects in pregnancy, the development of embryos and fetal fetuses. Acetylcystein should be used during pregnancy after being carefully evaluated between risks and benefits.

Breastfeeding period

There is no information on the excretion of acetylcystein into breast milk. Acetylcystein should be used during pregnancy only after being carefully evaluated between risks and benefits.

Medicinal interaction

Please inform your doctor or pharmacist that you have been or recently used, including non -prescribing drugs.

cough pills

Simultaneous use of acc 200 with cough medicine can cause serious mucus obstruction due to cough reduction, so this type of combination of treatment should be based on accurate treatment indications.

Antibiotics

Reports on acetylcystein causes antibiotic loss based on In vitro tests in which substances are directly mixed. However, to ensure safety, antibiotics should be taken away from acetylcysteine at least 2 hours. There is no such interaction for Cefixim and Loracarbef.

Acetylcysteine may increase the vasodilation effect of nitroglycerin. Hence should be cautious when using.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

24 -month expiry date from the date of production.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.