Mobimed 15mg Pymepharco Treatment of rheumatoid arthritis, spondylitis (2 blisters x 10 tablets)

Dosage form Box of 2 blisters x 10 tablets
Specifications Meloxicam

Ingredient

Composition information	Content
Meloxicam	15mg

Uses

Indications

Mobimed 15 drugs are indicated for long -term symptomatic treatment of chronic pain in:

rheumatoid arthritis.

A joint spine inflammation.

Pharmacy

Meloxicam is an non -steroid anti -inflammatory drug (NSAID) of the enolic acid family, which has anti -inflammatory, analgesic and antipyretic effects. Meloxicam has strong anti -inflammatory properties for all types of inflammation. The general mechanism is because Meloxicam has the ability to inhibit prostaglandin biosynthesis, chemical mediators that cause inflammation.

pharmacokinetics

After drinking, Meloxicam has an average bioavailability of 89%. Plasma concentrations proportional to the dose: When taking 7.5mg and 15mg, the average plasma concentration is recorded from 0.4 -1mg/l and 0.8 - 2mg/l.

Meloxicam is strongly linked to plasma proteins, mainly albumin (99%). Low, average distribution volume is 11L and ranges from 30-40%. The distribution integral increases if the patient has severe renal failure. The drug is strongly metabolized, especially oxidized at the methyl root of thiazolel.

The unchanged product ratio is excreted accounting for about 3% of the dose. The drug is half excreted through the urine, half through the part. The average emission time is 20 hours. The average plasma clearance is 8 ml/min and decreases in the elderly.

Before taking Mobimed 15mg Pymepharco Treatment of rheumatoid arthritis, spondylitis (2 blisters x 10 tablets)

How to use

use by oral.

Dosage

rheumatoid arthritis, joint spondylitis: 15mg/day.

Children: The dose has not been determined.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Currently, there is no specific antidote. In some clinical experiments, using Cholestyramin will increase the elimination of meloxicam. Severe injuries on the gastrointestinal tract can be treated with antacids and antihistamine H2.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Mobimed 15, you may experience unwanted effects (ADR).

Common

Constipation, diarrhea, flatulence, indigestion, nausea, stomach pain, vomiting, headache.

rarely

Abnormal test results, belching, dizziness, gastritis, ulcers or gastrointestinal bleeding can be fatal. Stomatitis, edema, hypertension. Stevens - Johnson syndrome, toxic epidermal necrosis, anaphylaxis, urticaria, increased skin sensitivity to light, itching, diverse roses, drowsiness, dizziness.

rarely

Asthma, blurred vision, colitis, hepatitis, esophagitis, nightmares, chest drums, tinnitus.

In addition, there may be a risk of cardiovascular thrombosis (see the cautious part).

Instructions on how to handle ADR

Notice the unwanted physician when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Mobimed 15 contraindications in the following cases:

Patients with hypersensitivity to drug ingredients.

Cross -sensitive with aspirin and other NSAIDs.

Not used for patients with signs of asthma, nasal polyps, angiography or urticaria due to Aspirin and NSAIDs.

Progressive peptic ulcer.

Severe liver failure.

Severe kidney failure without dialysis.

Pregnant and lactating women.

Children under 12 years old.

Caution when using

Patients with a history of the above gastrointestinal disease, being treated with anticoagulants, adverse reactions on the skin.

Patients are at risk of reducing blood flow, body and blood volume such as dehydration, congestive heart failure, cirrhosis, nephrotic syndrome using diuretics or elderly people, exhausted patients.

Must stop using Meloxicam immediately if the appearance of stomach - duodenum or gastrointestinal bleeding.

Meloxicam dose for patients with end -stage renal failure must not exceed 7.5mg/day. Mild or moderate renal failure (patients with creatinine clearance greater than 25m/minute) without reducing dose.

As most of NSAIDs, drugs may increase serum transaminase or other liver function parameters (usually few and transient). Drugs should be stopped and conducted monitoring tests if this increase is significantly or abnormally.

No dose reduction for clinical stable cirrhosis patients.

Caution used in the elderly.

Risk of cardiovascular thrombosis: NSAIDs are not aspirin, using systemic sugar, which can increase the risk of cardiovascular thrombosis, including myocardial and mutant infarction, which can lead to death. This risk can appear early in the first few weeks of taking the drug and can increase over time. The risk of cardiovascular thrombosis is recorded mainly at high doses.

Doctors need to periodically evaluate the appearance of cardiovascular events, even if the patient has no previous cardiovascular symptoms. Patients should be warned of symptoms of serious cardiovascular events and need to visit the doctor as soon as they appear.

To minimize the risk of adverse events, Meloxicam is needed at the lowest daily doses in the shortest possible effect as possible.

The ability to drive and operate machinery

The drug does not affect the ability to drive and operate machinery. However, it is advisable to avoid the above activities if there are unwanted use such as dizziness, falling asleep.

Pregnancy

Experimental research does not see Meloxicam's teratogenic evidence. However, Meloxicam is recommended not to be used for pregnant women, especially in the last 3 months of pregnancy for fear of early pacifies or other complications for the fetus.

Breastfeeding period

should not use meloxicam during breastfeeding. If you need to use medication for mothers, you should not breastfeed.

Medicinal interaction

Other nsaids: Increasing the risk of gastrointestinal bleeding due to impact force.

anticoagulant drugs, medications that soluble thrombosis: increased the risk of bleeding.

Lithi: Increased lithium concentration in plasma.

Methotrexate: Increasing toxicity on hematopoietic systems.

Diuretics: Increasing the potential of acute renal failure in dehydration patients.

Anti -blood pressure: Reducing the effect of hypotension.

Cholestyramin: Increasing Meloxicam elimination due to the bonding phenomenon in the gastrointestinal tract.

Storage

In a dry, cool place (under 300C). Avoid light.

Other drugs

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