Modom's 10mg DHG Pharma tablets treat symptoms of vomiting and nausea (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Domperidon

Ingredient

Composition information	Content
Domperidon	10mg

Uses

Indications

Modom's drugs are indicated for treatment of symptoms of vomiting and nausea.

Pharmacology

modom's with the active ingredient is Domperidon, a dopamine receptor resistant with anti -vomiting properties. The drug has almost no effect on the dopamine receptors in the brain so there is no effect on mental and nervousness. Domperidon stimulates the peristalsis of the digestive tract, increases the tasting muscle tone, increases the amplitude of pyloric sphincter extension after meals.

pharmacokinetics

absorption:

The drug is absorbed in the gastrointestinal tract, reaching the top concentration of plasma after about 30 minutes.

Distribution:

91-93 % attached to plasma proteins, widely distributed in tissues, but very little in the brain.

Metabolism:

Metabolic drugs through the liver and intestines.

Era:

Elimination by feces and urine.

Before taking Modom's 10mg DHG Pharma tablets treat symptoms of vomiting and nausea (10 blisters x 10 tablets)

How to use

modom's should only use the lowest doses effectively in the shortest time to control vomiting and nausea.

Should drink modom's before meals. If taken after meals, the drug may be slowly absorbed.

Maximum treatment time should not exceed a week.

Dosage

Adults and adults (aged 12 and older and weighing 35 kg or more):

10 mg tablets, can be used up to 3 times/day, a maximum dose of 30 mg/day.

infants, young children, children (under 12 years old) and adolescents weighs less than 35 kg:

Due to the exact dosage, the forms of tablets are not suitable for young children and adolescents weighing less than 35 kg.

Patients with liver failure:

Modom's contraindicated with patients with average and severe liver failure. No need to adjust the dose for patients with mild liver failure.

Patients with renal failure:

Due to the prolonged domeridon's sale time in patients with severe renal impairment, if used to repeat, the number of modem's drugs should be reduced to 1 to 2 times/day and adjust the dose depending on the degree of renal failure.

or as directed by the physician.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Should monitor the electrocardiogram because it is likely to extend QT.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using Modom's medicine, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Endocrine: Reduce libido, milk, menstrual disorders, menstruation, big breasts or breast pain due to serum prolactin hyperkemin can be seen in patients with prolonged high doses.

immune: Rashes and other allergic reactions. cardiovascular: cardiovascular disorders.

Rare, 1/10000

Cardiovascular: ventricular arrhythmia, extend QT, torsion, heart sudden death.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Modom's contraindications in the following cases:

vomiting after surgery.

Patients with gastrointestinal bleeding, mechanical intestinal obstruction.

Children under 1 year of age.

Used often or for a long time.

Patients with average and severe liver failure.

Patients with prolonged heart impulse transmission time, especially QT interval, patients with clear electrolytes or patients with cardiovascular disease such as congestive heart failure.

Simultaneously used with drugs that extend QT.

Simultaneously used with CYP3A4 inhibitors (regardless of the effect of extending QT).

Be cautious when used

only use domeridon for no more than 12 weeks for Parkinson's patient. Harmful effects in the central nervous system may appear. Only use domperidon for Parkinson's patient when other anti -vomiting measures are safer. Patients with liver dysfunction and kidney function.

kidney failure:

Domperidon's waste time is prolonged in patients with severe renal impairment. In case of repeat use, the frequency of giving domperidon should be reduced to 1 to 2 times/day depending on the level of renal failure. Can adjust the dose if needed.

Cardiovascular effects:

domperidon extends the QT interval on the electrocardiogram. In the process of post -commerce monitoring, there are very few reports on the QT and vertical torsion related to the use of domperidon. These reports have risk factors such as electrolyte disorders or simultaneous medications.

Epidemic studies show that domeridon may increase the risk of serious ventricular arrhythmia or sudden cardiovascular disease. This risk is higher for patients over 60 years old, patients taking daily doses greater than 30 mg and patients with simultaneous use of the drug extending the QT or CYP3A4 inhibitors.

Use domperidon with the lowest doses effectively in adults and children.

contraindicated domeridon for patients with prolonged heart impulse conduction time, especially QT interval, patients with clear electrolytes (hypotension Electrolyte disorders (hypotension, hyperkalemia, hypoglycemia) or bradycardia have been known as a factor that increases the risk of arrhythmia.

Need to stop treatment with domperidon and exchange with health workers if there are any symptoms or signs related to arrhythmia.

Advise patients to quickly report symptoms on the heart.

Related to Lactose excipients:

Patients with rare Galactose genetics problems, lactase lactase or glucose - Galactose should not be used should not use this drug.

The ability to drive and operate machinery

There is no document on the effect of the drug on driving and operating machinery.

Pregnancy

Avoid drugs for pregnant women.

breastfeeding period

domperidon excreted through breast milk and breastfed babies receive less than 0.1% dose according to the mother's weight. The adverse effects, especially the effect on the heart can still occur after breastfeeding.

Consider the benefits of breastfeeding and the benefits of treatment for mothers to decide to stop breastfeeding or stop/avoid domeridon treatment. Caution should be careful in case of risk factors that extend the QT range in breastfeeding.

Interactive drug

anti -cholinergic drugs, opioid analgesics and antacarinic drugs inhibit the effect of domeridon.

Increase the risk of extending the QT distance due to pharmacokinetics or pharmacokinetic energy.

contraindicated with the following drugs:

Medications that extend the QT range:

IA's anti -arrhyths (for example: disopyramid, hydroquinidin, quinidine).

Anti -arrhythmia group III (for example: Amiodaron, dofetilid, droneedaron, ibutilid, sotalol).

Some anti -psychotic drugs (for example: Haloperidol, Pimozid, Servindol).

Some antidepressants (e.g. citalopram, Escitalopram).

Some antibiotics (for example: erythromycin, levofloxacin, moxifloxacin, spiramycin).

Some antifungal drugs (for example, pentamidin).

Some medications for malaria treatment (especially halofantrin, lumefan trin).

Some gastric - intestinal drugs (for example: Cisaprid, Dolasetron, Prucaloprid).

Some antihistamine drugs (for example: Mequitazin, Mizolastin).

Some cancer treatments (for example: Toremifen, Vandetanib, Vincamin).

Some other drugs (for example: Bepridil, Diphemanil, Methadon).

Strong CYP3A4 inhibitors (regardless of the effect of extending QT), for example:

Protease inhibitors.

Azol body antifungal drugs.

Some macrolid drugs (erythromycin, clarithromycin and telithromycin).

It is not recommended to use the following drugs:

Average CYP3A4 inhibitors, for example: diltiazem, verapamil and some macrolid drug groups.

Use the kidneys while using the following drugs:

Heart rate slow, medications that reduce blood potassium and some of the following macrolid drugs contribute to extending the QT interval: azithromycin and Roxithromycin (contraindicated clarithromycin as a powerful CYP3A4 inhibitor).

The list of substances above is representative and incomplete drugs.

Storage

In a dry place, the temperature does not exceed 30 ° C, avoiding light.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.