MOLOXCIN 400 DHG treats infections, pneumonia (1 blister x 10 tablets)

Dosage form Box of 1 blister x 10 tablets
Specifications Moxifloxacin

Ingredient

Composition information	Content
Moxifloxacin	400mg

Uses

indications

Moloxcin drug indicated in the following cases:

Treatment of bacterial infections caused by moxifloxacin sensitive bacteria in community pneumonia, skin infections and subcutaneous organization. So).

moxifloxacin has better printing effects than ciprofloxacin, levofloxacin and ofloxacin on streptococcus pneumoniae (including penicillin -resistant strains) and is relatively effective for gram -negative bacteria and non -typical bacteria (chlamydia pnumoniae, mycoMoniae Legionella spp.).

moxifloxacin works both in vitro and clinically with most staphylococcus aureus (methicilin sensitive strains), streptococcus pyogenes, haemophilus influenzae, H. parainfluenzae, klebsiella pneumoniae, morexella cacinhdis, chlamydiadiadiadia Pneumoniae and Mycoplasma Pneumoniae.

Moxifloxacin resistant bacteria: In vitro, anti -drug bacteria grow slowly through many mutant steps. There has been a cross -resistance between moxifloxacin and other fluoroquinolones for gram -negative bacteria. However, other gram -positive bacteria with other fluoroquinolones may still be sensitive to moxifloxacin.

Pharmacokinetics

absorption

moxifloxacin is quickly absorbed through the gastrointestinal tract, absolute bioavailability is 90%. Eating does not affect absorption.

Distribution

moxifloxacin is widely distributed throughout the body, both in saliva, secretion of bronchial nose, sinus mucosa, fluid in the skin, subcutaneous and skeletal muscles after drinking 400 mg, the concentration in tissue is usually superior to plasma concentrations.

Metabolism

No report.

Elimination

Moxifloxacin's waste time is about 12 hours, so take medicine 1 time/day.

Before taking MOLOXCIN 400 DHG treats infections, pneumonia (1 blister x 10 tablets)

How to use

Moloxcin pills form film tablets for oral, can be used before, during or after meals.

Dosage

Adults

The usual dose is 400 mg x 1 time/day.

Treatment time:

Acute sinusitis, mild and medium -sized community pneumonia: 10 days.

Skin infections and subcutaneous organization: 7 days.

Exacection of chronic bronchitis: 5 days.

Acute sinusitis caused by bacteria: 10 days.

Patients with kidney failure and liver failure

No need to change the dose for people with renal impairment, mild to moderate liver failure and the elderly. Moxifloxacin has not been studied in people with dialysis or people with severe liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose?

There is no specific treatment, mainly symptomatic and supportive treatment.

Treatment of drugs from the stomach and compensation, monitoring the electrocardiogram.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned.

Note that it should not be used double the prescribed dose.

Side Effects

When using Moloxcin, you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: vomiting, diarrhea.

Neurological: dizziness.

Uncommon, 1/1000

Digestive: abdominal pain, indigestion, dry mouth, mild taste disorders.

nerve: headache, convulsions, depression, confusion, trembling, insomnia, restlessness, anxiety, sleeping chicken.

Body: itching, erythema.

Liver: Increased amylase, lactat dehydrogenase.

Muscle muscle: joint pain, muscle pain.

Rare, ADR

Digestive: diarrhea caused by C. difficile.

Cardiovascular: extends the QT range.

musculoskeletal joints: Achille tendon and other tendons. Neurology: hallucinations, vision disorders, neurasthenia.

Instructions on how to handle ADR

Need to stop moxifloxacin immediately when: There is any sign of hypersensitivity reactions; There are signs of unwanted effect on the nerves (such as convulsions, depression, confusion, hallucinations, trembling, ...); Pain, inflammation or sprain.

Manifestations of digestive disorders such as nausea, vomiting, abdominal pain, taste disorders are often mild without treatment intervention. If there are signs of fake colitis, it is necessary to monitor the degree of diarrhea, if severe must be treated with other antibiotics appropriately.

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Moloxcin drug contraindicated in the following cases:

Hypersensitivity to moxifloxacin and other quinolones or any ingredients of the drug.

Children under 18 years old.

People with prolonged QT history and are using anti -arrhythmia IA (Quinidin, Procainamid, ...), Group III (Amiodaron, Sotalol, ...).

Caution when used

The reactions are harmful to the ability to not recover and cause disabilities, including: tendonitis, tendon, peripheral neuropathy and other adverse effects on the central nervous system (hallucinations, anxiety, depression, insomnia, severe headache and confusion). These reactions can occur within hours until several weeks after using the drug.

Patients at any age, with or without risk factors may experience these reactions. Stop taking the drug as soon as there are signs or first symptoms of any serious harmful reactions. Avoid using Fluoroquinolon antibiotics for patients who have had the above side effects.

Because moxifloxacin can cause prolonged QT about the electrocardiogram, it is necessary to be cautious when using moxifloxacin along with drugs such as cisapril, erythromycin, 3 -round antidepressants, anti -psychotic drugs.

Be cautious when using moxifloxacin in patients with arrhythmia such as slow rhythm and acute myocardial ischemia; People with central neuropathy such as severe brain arteriosclerosis, epilepsy.

Fluoroquinolon, including moxifloxacin, is associated with increased risk of tendonitis and ligament hernia in all age groups. This risk is increasing in the elderly (usually people over 60 years old), patients are using Corticosteroids simultaneously, and kidney, heart, or lung transplant.

Other factors may increase the risk of ligament hernia, including physical exertion, kidney failure, previous tendon disorders such as rheumatoid arthritis. Tenditis and ligament hernia have been reported in patients using fluoroquinolon without any of the above risk factors.

Ribbed and ligament hernia is caused by fluoroquinolon, which is often associated with heel tendon and may need surgery for treatment. Tenditis and ligament hernia in the shoulders, hands, biceps, thumb, and other tendons have also been reported.

Ligament hernia can occur during or after Fluoroquinolon treatment and have been reported to last up to several months after the end of treatment.

Advise patients to rest and stop exercising, and contact the doctor when the first sign of tendonitis or ligament hernia (such as pain, swelling, inflammation or ligament or weak or unable to use one joint). Stop drinking moxifloxacin if the pain, swelling, inflammation, ligament hernia appears.

The ability to drive and operate machinery

Caution when driving and operating machinery.

Pregnancy

Do not use moxifloxacin for pregnant women.

Breastfeeding period

Do not breastfeed when using moxifloxacin.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

antacids, preparations containing iron, multivitamine containing zinc, sucralfate, ... can reduce the absorption of moxifloxacin, so drink at least before 4 hours or after 8 hours.

When used with warfarin, moxifloxacin increases anticoagulant effects.

Increased risk of central nerve stimulation and convulsions when used simultaneously with nonsteroidal anti -inflammatory drugs.

Response to the effect of prolonged QT interval.

Storage

In a dry place, the temperature does not exceed 300C, avoiding light.

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