MOprazol hard capsules 20mg Imexpharm treat stomach ulcers (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Omeprazol

Ingredient

Composition information	Content
Omeprazol	20mg

Uses

Indications

PMS-MOPRazol® is indicated in the following cases:

reflux esophagitis .

Stomach - duodenal ulcer. H+/K+ ATPASE in the border cells of the stomach.

The effect is fast, prolonged but recovered. Omeparazol does not work on acetylcholin receptor or histamine receptor. Maximum effect after taking 4 days.

pharmacokinetics

omeprazol is completely absorbed in the small intestine after drinking from 3 hours to 6 hours. Biology is about 60%. Food does not affect the absorption of drugs in the intestine. The absorption of omeprazol depends on the dose.

The drug can increase its own absorption and bioavailability due to acidic excretion. The drug is highly attached to plasma proteins (about 95%) and is distributed in tissues, especially the border cells in the stomach, the biological use of the first oral dose is about 35%, but will increase to about 60%when drinking the next day.

Despite the short selling time (about 40 minutes), the acid excretion inhibitor effect is prolonged, so it can be used only once a day.

Omeprazol is almost completely metabolized in the liver, quickly excreted, mainly through urine (80%), the rest is too stool. The metabolites are not active, but interact with many different drugs due to inhibiting the enzymes of the cytochrom P450 of liver cells.

The pharmacokinetics of the drug are not changed significantly in the elderly or the patient with renal function. In people with liver failure, the bioavailability of the drug increases rapidly and the clearance of drugs decreases, but there is no accumulation of drugs and metabolites of the drug in the body.

Before taking MOprazol hard capsules 20mg Imexpharm treat stomach ulcers (10 blisters x 10 tablets)

How to use

PMS-MOPRazol Used oral.

Dosage

Rock reflux esophagitis: 20 - 40 mg x 1 time/day, drink for 4-8 weeks. Then maintain: 20 mg x 1 time/day.

Ta -coated ulcer: 20 mg/day, drink for 4 weeks.

Stomach ulcer: 20 mg/day, taken for 8 weeks.

Zollinger - Ellison syndrome: The starting dose of 60 mg x 1 time/day, then adjust the dose depending on the patient and the treatment time depending on the clinical manifestation. If the dose is over 80 mg, divide 2 times daily.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? When overdose indicated symptomatic treatment, no specific treatment.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using PMS-MOPRazol® , you may experience unwanted effects (ADR).

Common

headache, drowsiness, dizziness, nausea, vomiting, abdominal pain, constipation, bloating.

Insomnia, sensory disorders, dizziness, fatigue, urticaria, itching, rash, temporary increase Transaminase.

Rare:

Sweating, peripheral edema, hypersensitivity including angioedema, fever, anaphylaxis, leukopenia, thrombocytopenia, reducing all blood cells, loss of granulocytes, recovery, agitation, depression. jaundice, cerebral disease in liver failure, bronchospasm, joint pain, muscle pain, interstitial nephritis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

PMS-MOPRazol® contraindicated in the following cases:

Sensitive to the drug ingredient.

First 3 months of pregnancy.

Be cautious when using

Before giving stomach ulcers using omeprazol, the possibility of malignant tumor (the drug can cover symptoms, so it is late to diagnose).

The ability to drive and operate machinery

There has been no report on the effect of the drug on the ability to drive and operate machinery.

Pregnancy

Although experiments do not see omeprazole is likely to cause deformities and toxic to the fetus, but should not be used for pregnant women, especially in the first 3 months of pregnancy.

The period of breastfeeding

should not use omeprazol in nursing mothers. So far, no research documents can conclude specifically on this issue.

Drug interaction

omeprazol does not have clinically important interactions when used with food, alcohol, amoxicillin, bacampicillin, caffeine, lidocaine, quinidine or theophylin. The drug is also not affected by simultaneous use of Maalox or Metoclopramide.

omeprazol may increase the concentration of ciclosporin in the blood.

omeprazol increases the effects of antibiotic eradication H.pylori.

Omeprazole inhibits the metabolic of drugs metabolized by the enzyme system in Cytocrom P450 and can increase the concentration of diazepam, phenytoin and warfarin in the blood. The metabolism of diazepam makes the effect of the drug longer.

With a dose of 40 mg/day omeprazole inhibits phenytoin metabolism and increases the concentration of phenytoin in the blood, but the dose of omeprazole 20 mg/day has weaker interactions. Omeprazol inhibits the metabolism of warfarin, but rarely changes bleeding time.

omeprazol increases Dicoumarol's anticoagulant effect.

omeprazol reduces nifepirin metabolism at least 20% and may increase the effect of nifedipin.

Clarithromycin inhibits omeprazol metabolism and doubled Omeprazole levels.

Storage

less than 300C, avoid moisture and avoid light.

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