MOSAD MT -5 Torrent Treatment Treatment of gastric - intestinal symptoms (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Mosaprid citrate

Ingredient

Composition information	Content
Mosaprid citrate	5mg

Uses

indications

Mosad MT - 5 drugs are indicated in the following cases:

Treatment of gastric - intestinal symptoms combined with functional indigestion (chronic gastritis), heartburn, nausea/vomiting.

Pharmacokinus

The gastric movement effect: This drug increases gastric and duodenal movement after a dog meal.

The effect of enhancing the empty gastric empty: This drug enhances the removal of the stomach empty containing liquid (in mice and mice) and solids (in mice). The effect of enhancing the empty gastric hollow decreases after the dose is repeated for 1 week (in mice).

In the experiment of the empty gastric emptiness in healthy adults and patients with chronic gastritis, the only dose of these 5 mg increases the emptiness of the stomach.

Mechanism of action

Acetylcholin secretion, gastric hyperactivity drugs. Mosaprid is a slippery motor hyperthematic drug with chemical structure similar to Metoclopramid. The drug enhances the release of acetylcholin from the end of the nerve after the lymph nodes of the intestinal muscle plexus in the smooth muscle of the gastrointestinal tract and is the serotonin 5 -HT4 receptor receptor. Mosaprid increases the pressure of lower esophageal sphincter (stomach and small intestine).

Dynamic pharmacokinetics

mosaprid is quickly absorbed after oral, the highest drug concentration in the stomach, part of the liver and kidneys. Then distributed with high concentrations in plasma, not distributed to the brain. In healthy people and hungry stomachs faster.

Plasma peak concentration is achieved after 0.5 hours. Up to 99% Mosaprid binds to plasma proteins.

Selling time is 2 hours.

Mosaprid is metabolized in the liver by CYP3A4 enzymes of Cytochrom P450, for metabolic substances mainly DES - 4 - Fluorobenzyl - Mosaprid and excreted mainly in diabetes.

Before taking MOSAD MT -5 Torrent Treatment Treatment of gastric - intestinal symptoms (10 blisters x 10 tablets)

How to use

oral medication. Take medicine before or after meals.

Dosage

For adults, the daily dose is usually 15 mg of mosapride citrate in anhydrous form, divided into 3 drinks before or after meals.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Symptoms

vomiting, boiling stomach, bloating, great, urination many times.

Handling

Stomach and/or active carbon use, closely monitor patients and body support treatment.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using MOSAD MT - 5, you may experience unwanted effects (ADR).

Side effects that appear sometimes depend on the dose, sometimes independent. The most common is diarrhea and abdominal pain (about 10%). These reactions often occur due to the pharmacological effects of Mosaprid and will gradually end.

Common, ADR> 1/100

Digestive: diarrhea, abdominal pain, flatulence, dry mouth.

Liver: Increase liver enzyme.

Neurology: headache, dizziness, dizziness.

Hematology: Eosin hypernagus, leukopenia.

Increase triglycerides.

Uncommon, 1/1,000

Systemic: transient headache, dizziness.

Digestive: nausea.

Rare, ADR

Body: Hypersensitivity reaction, skin flush, itching, shortness, swelling.

Central nervous system: Symptoms outside the tower, epilepsy.

Endocrine: Breast disease in men, lots of milk.

Liver: Increase liver enzyme.

urinary tract: urination many times.

Note: A few cases have prolonged and/or vertical QT gaps that have been seen in people who have heart disease or risk of arrhythmia.

Instructions on how to handle ADR

Monitoring side effects, especially diarrhea and abdominal spasms.

Need to reduce the dose when seeing diarrhea in young children. If there is abdominal pain, at a dose of 5 mg/kg, the recommended dose should be used for 24 hours.

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Mosad MT - 5 contraindications in the following cases:

Hypersensitivity to mosaprid or other ingredients of the drug.

Gastrointestinal bleeding, gastrointestinal blockage.

Perforated gastrointestinal tract or cases of danger when stimulating gastrointestinal movement.

Simultaneously used with ketoconazole, otraconazole, miconazole, fluconazole, erythromycin, clarithromycin, troleandomycin and ritonavir.

The patient has a long QT range, the patient is at risk of prolonged QT, such as due to a decrease in potassium or missesi deficiency, or when treated simultaneously with other drugs, which can cause an increase in QT.

Be cautious when using

Pregnant women, nursing mothers, premature babies, have mechanical clogged symptoms.

When stimulating the gastrointestinal tract may be dangerous such as obstruction, perforation and gastrointestinal bleeding.

Be cautious when taking medication for patients: heart failure, ventricular arrhythmia (including torsion), transmission defects, local myocardial ischemia, electrolyte disorders, hypokalemia, simultaneous use with rapid reduction of potassium potassium (Furosemid), liver failure.

Be careful when using mosaprid at the same time with the drugs that extend the distance QT (process, quinidine, 3 -round antidepressants).

Parameters to monitor

Monitoring the serum concentration at the beginning and when stopping treatment because the drug has a narrow treatment range.

In patients who are taking anticoagulants, monitoring prothrombin for a few days at the beginning of treatment or when stopping mosaprid.

The ability to drive and operate machinery

Because the drug can cause headaches, dizziness, dizziness, dizziness, it can affect the ability to drive and operate machinery.

Pregnancy

Mosaprid is toxic to the fetus of rats and rabbits. There is no enough research on pregnant people. Mosaprid should only be used for pregnant women when the treatment effect is much better than the risk that may occur with the fetus.

The period of breastfeeding. Effects on children are not clear.

Interactive drug

mosaprid increases the sedative effects of benzodiazepin and alcohol.

Increasing food from the stomach can affect the level of absorption (increase or decrease) other oral medications.

Mosaprid may increase blood clotting time in patients taking anticoagulants.

CYP3A4 inhibitors in the liver can significantly increase serum mosaprid concentration and extend the QT range, leading to ventricular arrhythmia, torsion and even death.

warfarin, diazepam, cimetidin, ranitidin, central neurological inhibitors, erythromycin, and macrolids and anti -fungal substances Triazol such as ketoconazol or miconazole increase mosaprid concentration.

anti -cholinergic drugs: Mosaprid can reduce the effects of anti -cholinergic drugs. Therefore, if used with anti -cholinergic drugs, taking these drugs should be spaced for a while.

Storage

In a dry place, avoid light, temperature below 30 ° C.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.