Motimilum Phuc Vinh medicine for symptoms of vomiting, nausea (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Domperidon

Ingredient

Composition information	Content
Domperidon	10mg

Uses

indications

Motimilum is indicated to treat symptoms of vomiting and nausea.

Pharmacokic

Domperidon is dopamine resistant, similar to metoclopramid hydrochloride. Because the drug has almost no effect on the dopamine receptors in the brain, domeridon has no effect on mental and nervousness. Domperidon stimulates the peristalsis of the gastrointestinal tract, increases the tasting muscle tone and increases the amplitude of the pyloric muscles after meals, but does not affect the excretion of the stomach.

The drug is used to treat nausea and vomiting, both nausea and vomiting due to the use of levodopa or bromocriptin in Parkinson's patient.

Dynamic pharmacokinetics

domperidon is absorbed in the digestive tract, but has low oral biological bio -biological (in hungry people only about 14%) due to the initial step metabolism of the liver and metabolism in the intestine. The drug is also absorbed when placed rectal or intramuscularly. After drinking or intramuscularly for about 30 minutes, the peak concentration in plasma; If the rectum is placed, after 1 hour. The biological use of the drug after oral oral increases significantly if taking the drug 90 minutes after eating, but the time to reach the peak concentration in plasma is slowed down. Biological use of the drug, after oral, increases in proportion to the dose of 10 to 60 mg. With the same dose, rectal biochemistry is similar to orally. 92 to 93% of drugs attached to plasma proteins. The drug metabolizes very quickly and is highly thanks to hydroxylation and reducing the oxidation of oxidation. Half -life eliminated in healthy people is about 7.5 hours and lasts for kidney failure. There is no phenomenon of drugs accumulated in the body due to renal failure, as the renal clearance is much lower than the total clearance of plasma.

Domperidon eliminates in feces and urine, mainly in the form of metabolites: 30% of the dosage of oral reversing in urine for 24 hours (0.4% is intact); 66% abundant in fertilizer within 4 days (10% is intact). Domperidon almost does not pass the blood - brain barrier.

Before taking Motimilum Phuc Vinh medicine for symptoms of vomiting, nausea (10 blisters x 10 tablets)

How to use

oral medication. Should drink Motimilum before meals. If taken after meals, the drug may be slow to fall.

Patients should take medicine at a fixed time. Maximum treatment time should not exceed a week.

Dosage

Should use domperidon with the lowest dose effective in the shortest time to control vomiting and nausea.

Adults and adolescents (from 12 years of age and weighing 35 kg or more): Take 10 mg (1 tablet)/time, 3 times/day, up to 30 mg (3 tablets)/day.

infants, young children, children (under 12 years old) and adolescents weighing less than 35 kg: Due to the exact dosage, the form of preparation of film bags is not suitable for young children and minors weighing less than 35 kg.

Patients with liver failure:

Motimilum is contraindicated for patients with severe and medium liver function impairment. No need to adjust the dose for patients with mild liver failure.

Patients with renal failure:

Due to the prolonged domeridon's selling time on patients with severe renal impairment, if used, the number of times the remedy of Motimilum should be reduced to 1 to 2 times/day and adjustment depending on the degree of renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Overdose:

Overdose domperidon often appears sleepy, loss of ability to determine the direction and syndrome, especially in children.

Management:

Acute and overdose management: gastrointestinal, active carbon, symptomatic treatment immediately. Should monitor the electrocardiogram due to the ability to extend the QT range. Anti -cholinergic drugs or Parkinson's medications are capable of helping to control the surgeon syndrome in case of overdose.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

If you forget 1 dose, you can skip the dose and continue taking the drug as scheduled as before. Do not double the dose to compensate for the forgotten dose.

Side Effects

When using MOTIMILUM drugs often experience unwanted effects (ADR) such as:

Uncommon, 1/100> ADR> 1/1000

Digestive: vomiting, nausea, diarrhea, dry mouth.

Domperidon is difficult to pass the blood -brain barrier and is less likely than Metoclopramid, which causes central nervous effects such as extracurricular reactions (including acute muscular disorders and malignant neuroleptic syndrome), convulsions. Foreign and drowsiness disorders occur with very low and often due to the absorbent disorders of the blood -brain barrier (premature babies, meningeal damage) or overdose.

Milk melting, menstrual disorders, menstruation, big breasts or breast pain, decreased pleasure due to serum prolactin hyperkemin can be found in patients with long -doses of high doses.

The risk of severe ventricular or sudden death due to cardiovascular disease in patients daily doses of over 30 mg and patients over 60 years old.

Anaphylaxis allergic reactions, urticaria, and Quinck are rare to use domperidon.

Cardiovascular disorders: ventricular arrhythmia, extension of QT, twisted, sudden death due to cardiovascular.

Harmful reaction report:

The reaction report is harmful after the drug is licensed to circulate very important to continue monitoring the benefits/risks of the drug. Health workers need to report all the harmful reactions to the National Center or regional center on drug information and monitor the harmful reactions of the drug.

Instructions on how to handle ADR:

Notify the physician the unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

MOIMILUM drug contraindicated in the following cases:

Hypersensitivity to domperidon and any ingredients of the drug. Qt. Pregnant.

Be cautious when used

only use domeridon for no more than 12 weeks for Parkinson's patient. Harmful effects in the central nervous system may appear. Only use domperidon for Parkinson's patient when other, safer anti -vomiting measures are not effective.

The drug contains lactose excipients, this drug is not recommended for patients with rare genetic disorders in galactose intolerance, serious or poorly absorbed lactase deficiency.

kidney failure:

Domperidon's waste time is prolonged in patients with severe renal impairment. In case of repeat use, the frequency of giving domperidon should be reduced to 1 to 2 times/day depending on the level of renal failure. Can adjust the dose if needed.

Cardiovascular effects:

domperidon extends the QT interval on the electrocardiogram. In the process of post -commerce monitoring, there are very few reports on the QT and vertical torsion related to the use of domperidon. These reports have risk factors such as electrolyte disorders or simultaneous medications.

Epidemic studies show that domeridon may increase the risk of serious ventricular arrhythmia or sudden cardiovascular disease (see unwanted effect). This risk is higher for patients over 60 years old, patients taking daily doses greater than 30 mg and patients with simultaneous use of the drug extends the QT or CYP3A4 inhibitors.

Use domperidon with the lowest doses effectively in adults and children.

Contraindicated domperidon for patients with prolonged heart impulse transmission time, especially QT interval, patients with obvious electrolytes (hypokalemia, hyperkalemia, hypoglycemia), slow heartbeat or patients with cardiovascular disease such as congestical heart failure due to the risk of ventricular disorders.

electrolyte disorders (hypotension, hyperkalemia, hypoglycemia) or slow heart rate has been known as a factor that increases the risk of arrhythmia.

Need to stop treatment with domperidon and exchange with health workers if there are any symptoms or signs related to arrhythmia.

Advise patients to quickly report symptoms on the heart.

Use drugs for women during pregnancy and lactation

Pregnancy

There is no data on the safety of domeridon in humans, but using animal drugs has shown that the drug is likely to cause pregnancy defects, so it is not allowed to take the drug for pregnant people.

Breastfeeding period

Domperidon excreted breast milk and breastfed babies received less than 0.1% dose according to the mother's weight. The adverse effects, especially the effect on the heart, can still occur after a baby breastfed. The benefits of breastfeeding and the benefits of mothers treat to decide to stop breastfeeding or stop/avoid domeridon treatment. Caution should be careful in case of risk factors that extend the QT range in breastfeeding.

The effect of drugs on driving and operating machinery

Domperidon does not have or almost no effect on driving and operating machinery.

Interactive drug

Interactive drugs with other drugs and other types of interactions increase the risk of extending the QT distance due to pharmacokinetic or pharmacokinetic interaction.

Contraindicated with the following drugs:

Medications that extend the QT range:

IIA anti -arrhythmic drugs (for example: disopyramid, hydroquinidin, quinidin). SERTINDOL). Treatment of malaria (especially halofantrin, lumefantrin). Vandetanib, Vincamin).

Strong CYP3A4 inhibitors (regardless of the effect of extending QT), for example:

Protease inhibitors.

Do not recommend using the following drugs:

Average CYP3A4 inhibitors, for example: diltiazem, verapamil and some macrolid drug groups.

Use cautiously when used simultaneously with the following drugs:

Heart rate slow, medications that reduce blood potassium and some of the following macrolid drugs contribute to extending the QT interval: azithromycin and Roxithromycin (contraindicated clarithromycin as a powerful CYP3A4 inhibitor).

The list of substances above is representative and incomplete drugs.

Opioid analgesics and anti -cholinergic drugs can fight the effect of domperidon on gastrointestinal motility.

domperidon can be antagonistic effect that reduces plasma prolactin of bromocriptin.

domperidon may increase the speed of gastrointestinal absorption of paracetamol due to changing the gastrointestinal motility.

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

Other drugs

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