Mouthpaste medipharco oral gel gel reduces inflammation, lesions (5g)

Dosage form Tube x 5g
Specifications Triamcinolon acetonid

Ingredient

Thành phần cho 5g

Composition information	Content
Triamcinolon acetonid	5mg

Uses

Indications

Mouthpaste is indicated in the following cases:

Support treatment and temporarily reduce symptoms related to lesions in the oral mucosa, gums, lips and ulcerative lesions in the oral mucosa due to corticoid response. Triamcinolone acetonide has anti -inflammatory, anti -itching and vasoconstriction effects. The mechanism of anti -inflammatory effects of local corticosteroids is unclear.

glucocorticoid inhibits phospholipase A2, reducing the synthesis and release of leucotrien, prostaglandin. This effect is indirectly because glucocorticoid increases lipocortin production, is a protein present in the cell, which inhibits phospholipase A2. When phospholipase A2 is inhibited, phospholipids cannot be converted into arachidonic acid.

pharmacokinetics

The level of absorption through the oral mucosa is determined by many factors including liquid excipients in the gel formula, the integrity of the mucosal fence, the treatment time, the inflammatory form or the progression of other diseases.

When absorbed through mucous membranes, the distribution of topical corticosteroids is similar to that of the absorption of systemic corticosteroids.

triamcinolon is distributed into all tissues in the body (muscles, liver, skin, intestines, kidneys ...), through the fence - pregnancy and secretion into small amounts. Triamcinolone is linked to different levels of plasma proteins.

Metabolizes mainly in the liver, part of the kidney and excreted through the urine.

Before taking Mouthpaste medipharco oral gel gel reduces inflammation, lesions (5g)

How to use

Topical oral mucosa.

Dosage

Apply a small dot (about 0.5cm) to the damaged area, form a thin film, apply 2-3 times a day, preferably after meals. Larger gel can be applied to cover the damaged mucosa.

Do not use continuously for more than 8 days, avoid applying it to a large scale and apply it into a thick layer. Do not rub.

Apply medicine before going to bed so that the drug has time to act on the lesions of the mucosa.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? However, using corticosteroids at high and prolonged doses can lead to symptoms such as thin oral mucosa, increasing the risk of adrenal gland problems.

The risk of increasing children and patients taking large doses for a long time.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Mouthpaste , you may experience unwanted effects (ADR).

Local reactions may occur due to corticosteroids contained in mouthpaste gel: burning, hot, itching, irritation, dry mucosa, red mucosa, blistering, thin oral mucosa, dermatitis around the mouth, secondary infections, and the main epidermis of the product, oral mucosa.

The drug can be absorbed, causing systemic effect (carefully see information in caution).

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Mouthpaste contraindicated in the following cases:

Sensitive to any ingredients of the drug.

Cases of fungal infection, viral infection, mouth and throat infection.

Not used in the ophthalmology.

Caution when using

gel mouthpate can cause local reactions, stop taking the drug if there is skin irritation and contact dermatitis , apply appropriate treatment.

If the mucosal infection occurs and is developing, it is necessary to use additional antifungal or antibacterial drugs. If the adverse reactions occur when using Mouthpaste, it is necessary to stop the drug until the infection is improved.

If the lesions in the oral mucosa do not improve after 7 days of treatment, it is necessary to see a doctor to find the cause of the damage in the oral mucosa.

corticosteroid after local use can be absorbed in sufficient amounts to create systemic effects such as inhibiting hypothalamus - pituitary - adrenal glands, cushing syndrome, hyperglycemia, urinary hyperglycemia. To assess the inhibition of the hypothalamus - pituitary gland - the adrenal gland is needed to test the urine without cortisol, the ACTH stimulating test. If there is inhibition of the hypothalamus - pituitary gland - adrenal gland, it is necessary to stop using the drug immediately, reduce frequency or replace it with a weaker steroid.

Use drugs as directed by a doctor or dentist.

Only use drugs to apply oral mucosa, do not eat or drink after applying the drug.

Do not use for science or topical skin.

Be cautious with the elderly and children who are more likely to experience side effects.

Do not use more than 5 days for children.

Stop the drug if there is an irritation of the oral mucosa or have any side effects that occur when taking the drug.

If the disease does not improve after 2 weeks, it is necessary to see a doctor or dentist to find the cause of the disease.

HPA axis testing tests need to be conducted.

In the gel ingredient there are excipients:

methylparaben: can cause allergic reactions.

Propylparaben: can cause allergic reactions. Tartrazin color: can cause allergic reactions.

The ability to drive and operate machinery

There has been no research on the influence of the drug on the ability to operate machinery, driving train, higher -working people and other cases for Mouthpaste oral mucosa.

Pregnancy

Animal studies found pregnancy side effects (monitoring or pregnancy or other impacts) triamcinolone acetonide has been shown to cause teratogen on some species, in mice and rabbits, triamcinolone acetonide causing ratio of frogs in the dosage of about 120μg/kg/day for rats and mice and mice and mice and mice 24μg/kg/day for rabbits, corresponding (about 12 times and 10 times the daily dosage of gel triamcinolon acetonid in humans).

In monkeys, triamcinolone acetonide causes skull defects at the dose of 500mg/kg/day, equivalent to about 200 times the dose of triamciolon acetone gel in humans.

There is no full research on the side effects of the drug in pregnant women. However, an analysis of birth defects in children born from mothers using drugs of the same drug as the oral gel of the oral mucosa triamcinolon acetonid (corticoid) during pregnancy is at risk of cleft palate in the fetus. Need to consider the benefits and risks for the fetus when taking drugs in pregnant women.

Breastfeeding period

There has been no full research to prove that corticosteroids with oral mucosa are absorbed in the body and excreted with the amount that can be detected in breast milk. Be careful when using corticosteroid mucosa gel for women who are breastfeeding.

Medicinal interaction

Interaction of drugs

barbiturat, phenyltoin, rifampicin, ributin, carbamazepin, primidon and aminoglytethimide increases metabolism, corticoid clearance, reduces treatment effects.

Simultaneously used with Cumarin anticoagulants increases the effects of anticoagulants. It is necessary to check blood clotting time or prothrombin time to avoid spontaneous bleeding.

Tyeum of drugs

Due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a dry place, temperatures below 300C, avoid light.

Other drugs

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