Moxacin 500mg Domesco Treatment of infection cases (200 tablets)

Dosage form Box of 200 tablets
Specifications Amoxicillin

Ingredient

Composition information	Content
Amoxicillin	500mg

Uses

Indications

Moxacin 500 mg of domestco 200 tablets are indicated for use in cases of infections caused by sensitive bacteria:

Upper respiratory infection.

Lower respiratory infections due to streptococcal, pneumococcal, staphylococcus a staphylococcus non -secretion of penicillinase and H. Influenzae.

Inhabited urinary tract infections.

gonorrhea.

Bile infection.

Skin infections, muscles due to streptococcus, staphylococcus aureus, E. coli sensitive to amoxicillin.

Pharmacokology

amoxicilin is aminopenicilin, durable in acidic environment, with a wider spectrum than benzylpenicilin, especially anti -bacteria. Amoxicilin with bactericidal effects, due to inhibition of mucopeptide biosynthesis of bacterial cell walls. In vitro, amoxicillin is active with the majority of Gram -negative and gram -positive bacteria such as: streptococcal, staphylococcus aureus without penicillinase, H. Influenzae, diplococcus pneumoniae, N. Gonorrheae, E. coli, and Proteus Mirabilis. Like ampicilin, amoxicilin is not active with penicillinase secretion bacteria, especially staphylococcus aureus, all Pseudomonas strains and most of the Klebsiella and Entrecect strains.

Amoxicilin has a stronger printing effect than ampicilin for Enterococcus Faecalis and Salmonella spp., but less effective for Shigella spp .. The effect of amoxicillin can be wider when used simultaneously with sulbactam and clavulanic acid, a beta -lactamase inhibitor.

pharmacokinetics

amoxicillin sustainable in gastric acid environment. Absorption is not affected by food, faster and more completely through the digestive tract compared to ampicillin.

When taken in the same dosage as ampicillin, the concentration of amoxicillin peak in plasma is at least 2 times higher. Amoxicillin is quickly distributed into tissues and fluids in the body, except for brain tissue and cerebrospinal fluid, but when the meninges are inflamed, amoxicillin is easily diffused. After taking the dose of 250 mg amoxicillin 1 - 2 hours, the concentration of amoxicillin in the blood reaches about 4-5 mcg/ml, when taking 500 mg, the concentration of amoxicillin reaches about 8 - 10 mcg/ml. Double dose can increase the concentration of medication in the blood. Amoxicillin waste time is about 61.3 minutes, longer in infants, and the elderly. In people with kidney failure, the sale time of the drug is about 7-20 hours long. About 60% of the oral dosage of amoxicillin emitted urine within 6 - 8 hours. Probenecid extends the waste time of amoxicillin through the kidney. Amoxicillin has high concentrations in bile fluid and a part of feces.

Before taking Moxacin 500mg Domesco Treatment of infection cases (200 tablets)

How to use

Oral drugs.

Dosage

Adults and children over 10 years old: Common dose used 250 - 500 mg, every 8 hours.

Higher dose, single dose or in short phases, used in some diseases:

3 g dose, repeat again after 8 hours to treat abscess around the teeth or repeat after 10 - 12 hours to treat uncomplicated urinary tract infections.

To prevent pericardial inflammation in humans susceptible, for a single dose of 3 g, 1 hour before the procedure such as tooth extraction.

Use a 3 g of amoxicillin high doses 2 times/day for patients with severe or recurrent respiratory infections.

For people with renal failure, the dose must be reduced according to the creatinine clearance coefficient:

Cl Creatinin Cl Creatinin> 10 ml/min: 500 mg/12 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? Electric/water imbalance should be treated as symptoms. In the process of using high doses of Amoxicillin, the amount of water must be maintained in a satisfactory amount must be maintained and excreted by urinary tract to minimize the possibility of amoxicillin crystal crystal.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Moxacin 500 mg domesco 200 tablets, you may experience unwanted effects (ADR).

Common, ADR

Skin: Ban Ban.

Uncommon, 1/1000

Digestive: Nausea, vomiting, diarrhea.

skin: Red, lumpy and urticaria, especially Stevens - Johnson syndrome.

Rare, 1/10000

Liver: slight increase SGOT.

nerve: agitation, struggle, anxiety, insomnia, confusion, change of behavior and/or dizziness. blood: Anemia, thrombocytopenia, thrombocytopenic rash, Eosin hypernagus, leukopenia, granulocytosis.

Instructions on how to handle ADR

Notify the doctor with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Moxacin 500 mg domeso 200 tablets contraindicated in cases where patients have a history of allergies to penicilin.

Precautions when using

must periodically check the liver and kidney function during long -term treatment.

There may be severe hypersensitivity reactions in patients with a history of allergies to penicillin or other allergens, so it is necessary to carefully investigate the history of allergies to penicillin, cephalosporin and other allergens.

If the allergic reaction occurs such as erythema, edema, anaphylaxis, Stevens - Johnson syndrome, amoxicillin must be stopped and immediately treated emergency treatment with adrenalin, oxygen breathing, intravenous corticosteroid therapy, including internal trachea and never being treated with penicilin or cephalosporin again.

The ability to drive and operate machinery

The drug does not affect driving and operating machinery.

Pregnancy

only use this drug when really necessary during pregnancy. However, there is no evidence of harmful effects for the fetus when using amoxicillin for pregnant women.

Breastfeeding period

Because amoxicillin is excreted in breast milk, it is necessary to be cautious when taking the drug during breastfeeding.

Medicinal interaction

Absorption of amoxicillin is not affected by food in the stomach, so it can be taken before or after meals.

Nifedipine increases amoxicillin absorption.

When using allopurinol along with amoxicilin or ampicilin will increase the ability of ampicillin, amoxicillin.

There may be antagonists between amoxicillin and bactericidal substances such as chloramphenicol, tetracyclin.

Storage

less than 30 ° C, avoid direct light.

Other drugs

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