Muscat Tab 5mg Theragen Etex tablets treat chronic gastritis (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Mosapride

Ingredient

Composition information	Content
Mosapride	5mg

Uses

indications

Muscat tab drugs are indicated in the following cases:

Treatment of gastrointestinal symptoms (such as heartburn, nausea, vomiting) due to chronic gastritis. Clinical trials are only studied when using Mosaprid Citrate in combination with niflec intestinal induction (containing sodium chloride, potassium chloride, sodium bicarbonate and sodium sulfate).

When conducting a test of stomach empty in healthy people and patients with chronic gastritis, Mosaprid Citrate 5 mg for the effect of increasing the speed of stomach empty.

Effects to increase peristalsis at the upper part of the gastrointestinal tract:

The effect of increasing stomach and duodenal peristalsis: The drug for the effect of increasing stomach and duodenal peristalsis after eating and this effect depends on the dose (in dogs).

The effect of increasing the speed of stomach empty: The drug for the effect of increasing stomach and duodenal peristalsis for liquid foods (in mice, copper mice) or thick (in copper mice). On the other hand, taking repeated drugs in a week reduces the effect of increasing the speed of the stomach empty of the drug (in the mouse).

The effect of increasing peristalsis at the lower part of the digestive tract:

The effect of increasing the peristalsis of the colon and the transportation of food passing through the colon: the drug for the effect of increasing the peristalsis of the colon and the transportation of food passing through the colon and this effect depends on the dose (in the mouse).

The effect of bleaching and reducing the amount of water in the colon (when used simultaneously with the drug that causes the intestinal induction).

The drug enhances the intestinal cleansing effect of the drug that causes the niflec indentation (Niflec) and then reduces the amount of water in the colon (in the mouse).

Mechanism of action:

Mosaprid Citrate has a selective effect on the 5-HT4 receptor, and has an antagonistic of the 5HT-3 receptor. Mosaprid Citrate stimulates 5-HT4 receptors in the gastrointestinal nerve plexus, increasing acetylcholin release, resulting in increasing peristalsis of the digestive tract.

Pharmacokinetics

absorption

When using lone (5 healthy adults, use Mosaprid Citrate 5 mg per day, hungry): cmax 30.7 ± 2.7 ng/ml, Tmax 0.8 ± 0.1 hours, t1/2 2.0 ± 0.2 hours.

When used in combination with the drug that causes intestinal induction in healthy adults, using Mosaprid Citrate 20 mg (first dose) at hunger and the drug causing intestinal induction (Niflec): CMAX 116.1 ± 35.1 ng/ml, Tmax 1.0 ± 0.5 hours; 2 hours after the first dose of taking Mosaprid Citrate 20 mg (second dose): CMAX 272.6 ± 80.9 ng/ml, Tmax 2.5 ± 0.2 hours.

Distribution

99.0% (in vitro, human serum, 1 mcg/ml), determined by the super filter method or the equilibrium compassion (Equilibrium dialysis)).

Metabolism

The main metabolite of mosaprid citrate is Des-4-Fluorobenzyl. Mosaprid Citrate is mainly metabolized by removing 4-Fluorobenzyl root through Cytochrom P-450 CYP3A4 in the liver, then continues to be oxidized at the No. 5 position on the Morpholin and hydroxylation in the No. 3 on the benzene ring.

Elimination

drugs excreted through feces and urine. The ratio of the drug in urine 48 hours after drinking is 0.1% in a constant form and 7.0% in the form of the main metabolic substance (Des-4-Fluorobenzyl) (in healthy adults, the only dose of 5 mg, oral at hunger).

Before taking Muscat Tab 5mg Theragen Etex tablets treat chronic gastritis (10 blisters x 10 tablets)

How to use

Muscat tab tab.

Dosage

Treatment of gastrointestinal symptoms (such as hot, nausea, vomiting) chronic gastritis: Adult dose: Mosaprid Citrate 5 mg/time x 3 times/day. Drink before or after meals.

Supports in completely clean intestinal indent before performing X-rays: Adult dose: Mosaprid Citrate 20 mg, taken at the same time with the drug solution that causes the intestinal induction (about 180 ml). Or after using the drug causing intestinal indentation, taking Mosaprid Citrate 20 mg with a little water.

Note to carefully read the dose mode of the drug that causes the intestinal indentation and warnings related to the usage, the dose of this drug.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? In case of overdose, it is necessary to take the patient to the nearest medical facility for timely treatment.

What to do when forgetting 1 dose?

Not recorded.

Side Effects

When using Muscat Tab, you may experience unwanted effects (ADR).

When treating gastrointestinal symptoms due to chronic gastritis

Unwanted effects are recorded in 40 of 998 cases (4.0%). These effects are mainly diarrhea, loose stool (1.8%), dry mouth (0.5%), fatigue (0.3%) ...

Abnormal subclinical test values were detected in 30 of 792 cases (3.8%), including eosinophilia (1.1%), increasing triglycerides (1.0%), increasing AST (GOT), ALT (GPT), ALP and YGTP (each 0.4%) recorded in clinical trials before circulation.

According to the after -sales surveillance results of the drug, the unwanted effect is recorded in 74 of 3,014 cases (2.5%) specially monitored due to prolonged use: diarrhea, loose stool (0.8%), abdominal pain (0.4%), dry mouth (0.3%) ...

When assisted in completely clean intestine before making X-rays

Unwanted effects (including abnormalities in subclinical tests) were detected in 35 of 241 cases (14.5%), including abdominal distention (3.7%), nausea (3.3%), hidden blood in urine (2.1%), abdominal pain (1.2%), headache (1.2%), proteinuria (1.2%) ... According to the after -sales surveillance results of the drug, unwanted effects are recorded in 3 out of 1,306 cases (0.2%).

Serious unwanted effects: Acute hepatitis, severe liver failure, jaundice (each harmful effect occurs at frequency

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Muscat tab is contraindicated in the following cases:

Hypersensitivity to Mosaprid Citrate or any ingredient of the drug.

Caution when using

Special prudence:

When treating gastrointestinal symptoms due to chronic gastritis, it is necessary to assess the improvement of digestive symptoms after a certain period of time (usually 2 weeks) and consider the need to continue treatment.

Acute hepatitis, severe liver failure, jaundice may occur. Therefore, do not use the drug for a long time. In the process of using the drug, closely monitor and if there is any abnormalities, stop taking the drug immediately and proper treatment. At the same time, if there are symptoms such as fatigue, anorexia, concentrated urine, rash, yellow eye ... After starting to take the drug, the patient needs to stop taking the drug and contact the doctor.

When assisting in the entirely clean intestinal indent before performing X-rays: Note to read the warning, cautious, contraindicated, usage, unwanted effects ... described in the instruction sheet of the drug that causes the intestinal induction.

Elderly:

In the elderly, physiological functions such as kidneys and liver are usually impaired. Therefore, caution when using the drug by monitoring the patient's condition and. On the other hand, if unwanted effects are detected while using the treatment of gastrointestinal symptoms due to chronic gastritis, appropriate treatment measures such as by reducing the dose (Mosaprid Citrate 7.5 mg/day).

Children:

The safety of drugs in children has not been established, due to lack of experience used on this object.

Other warnings:

In a test on a rodent complex (100 mice, 92 mice) were given drinking for a long dose of 100-300 times the dose of clinical use (30-100 mg/kg/day), it recorded the increase in the frequency of tumors (tumor in the liver and thyroid tumor).

Note before use:

When providing medication, guide patients to pick up drugs from the blister and get new to the drug. There has been a report of the case due to accidentally swallowing the blister, part of the sharp edge of the blister hit the esophagus mucosa and then causing perforation of the esophagus leading to serious complications such as mediastitis.

Lactose-containing drugs should be cautious when using patients with rare genetic disorders such as galactose tolerance, lactase deficiency or glucose-galactose.

The ability to drive and operate machinery

Some side effects of the drug may occur such as dizziness, headache, so it is necessary to be cautious when using mosaprid citrate when driving and operating machinery.

Pregnancy

For pregnant women or possibly pregnancy, the drug is only used when it has assessed the benefits that are superior to the risk. The safety of the drug in pregnancy has not been established.

Breastfeeding period

Avoid using drugs for nursing women. When taking the drug, women have to stop breastfeeding. There have been drug reports excreted in milk in animal experiments.

Drug interaction

When shared with Erythromycin 1200 mg/day with mosaprid citrate 15 mg/day, compared to when taking Mosaprid Citrate alone, the peak concentration of mosaprid in the blood increases from 42.1 ng/mL to 65.7 ng/mL, the selling time increases from 1.6 hours to 2.4 hours and AUC up to 114 ng.

Precautions when using coordination:

Drugs

Clinical manifestations, management

Mechanism of interaction, risk factors

Due to the effects of mosaprid citrate may be reduced due to common use with anti -cholinergic drugs, note the use apart.

Due to the effect of increasing the gastrointestinal motility of the drug is explained by the mechanism of triggering sympathetic neurotransmitter, cholinergic drugs can inhibit this effect.

Storage

Store in closed packaging, temperatures below 300C, avoiding light and moisture.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.