MustFix-B.E 50mg Merap oral epidemic to treat otitis media, sinusitis (20 packs)

Dosage form Box of 20 packs
Specifications Cefixim

Ingredient

Thành phần cho 1g

Composition information	Content
Cefixim	50mg

Uses

indications

MECEFIX - B.E 50mg is indicated for the following cases of infections caused by sensitive bacteria:

Upper respiratory infections : bacterial sore throat, tonsillitis, otitis media, sinusitis.

Pharmacokological

cefixim is an antibacterial and stable antibiotic under the hydrolysis of many beta - lactamase. Cefixim is the third -generation cephalosporin antibiotic. Like other cephalospins, the bactericidal effect of cefixim is due to inhibition of cell wall synthesis. Cefixim stabilizes high in the presence of many beta - lactamase enzymes. Thanks to this result, many bacteria are resistant to penicillin and some cephalosporin in the presence of beta - lactamase enamel may be sensitive to cefixim.

Cefixim has been shown that the activity for most of the following bacteria strains on both in vitro and clinical infections:

Gram -positive bacteria: Streptococcus pneumoniae, Streptococcus pyogenes. Escherichia Coli, Proteus Mirabilis, Neisseria Gonorrhoeae (including strains and non -secretional penicillinase).

Gram -positive bacteria: Streptococcus agalactiae. Species, Shigella Species, Citrobacter Amalonaticus, Citrobacter Diversus, Serratia Marcescens. Methicillin resistant strains) and most Entobacter strains are resistant to cefixim. In addition, most bacteriodes fragilis strains and Clostridia are resistant to cefixim.

pharmacokinetics

cefixim orally, absorbed about 40-50% in the presence of food; However, the maximum absorption time increases about 0.8 hours when used with food.

Peak concentration in plasma is 2 to 3g/ml and 3.7 - 4.6g/ml after taking a single dose of 200 and 400mg about 4 hours. Selling plasma waste time is usually about 3 to 4 hours and may last for kidney failure. About 65% Cefixim in the blood is attached to plasma proteins.

Information about Cefixim's distribution in tissues and fluid fluids is limited. The drug through the placenta. About 20% of oral dose is excreted in the form of unchanged urine within 24 hours. Over 60% can be metabolized without kidneys; There is no evidence of metabolism, but it is certain that part is secreted in biliary tract.

Before taking MustFix-B.E 50mg Merap oral epidemic to treat otitis media, sinusitis (20 packs)

How to use

MECEFIX - B.E 50mg Used orally.

Mixing:

Pour the nuggets from the package into the cup.

Dosage recommended 200 - 400mg per day, use a single dose or divided into two times.

Intractive respiratory infections and uncomplicated urinary tract infections: 200mg/time/day.

Lower respiratory infections: 400mg/day.

In the case of sinusitis: The treatment must be used from 10 - 14 days.

Treatment of uncomplicated gonorrhea: The recommended dose is only 400mg oral once.

Children and children under 12 years old

The recommended dose is 8mg/kg per day, using a single dose or divided into 2 times. Patients with more severe or incomplete symptoms, can increase the dose to 6mg/kg twice daily.

The weight of children (kg)

Dosage/day (mg)

6.25

12.5

100

18.75

150

200

31.25

250

37.5

300

Patients with renal failure

Should reduce the dose in patients with severe to severe renal failure. For patients with renal failure with creatinine clearance below 20ml/min, the dose does not exceed 200mg/day.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose? MECEFIX - B.E 50 is not removed from the blood of a large amount of hemorrhage or peritoneal fertilizer. Side reactions on a small number of healthy volunteers when taking the only 2G Cefixim dose is no different from the patients treated at the recommended dose.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when forgetting 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using the drug, you may experience unwanted effects (ADR).

Digestive: diarrhea, abdominal pain, indigestion, nausea and vomiting. Some cases of fake colitis have been discovered in studies. The initial symptoms of fake colitis may occur during or after treatment. Polymorphic erythematosus, Stevens - Johnson syndrome, and serum -like reactions have reported. Bright platelets. Prothrombin is rarely encountered.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindications for patients who have known allergies to cephalosporin antibiotics.

Be cautious when used

Caution for patients with previous allergic reactions with cephalosporin, penicillin. The ratio of cross -allergy between beta -lactam antibiotics and patients with a history of penicillin allergies may occur.

Note: The ability to develop resistance bacteria that can be due to excessive growth, especially when long -term treatment.

Safety and efficiency when using Cefixim for children under 6 months of age is not recorded, so be careful when used for children under 6 months old.

Caution in patients with a history of digestive disease, especially colitis.

The ability to drive and operate machinery

Because the drug can cause headaches, dizziness should be cautious when using drugs for drivers and machinery operation.

Pregnancy and lactation

Pregnancy

Safety for pregnant women has not been verified, only used when necessary.

The period of breastfeeding

Do not know if the cefixim is in human milk or not, only used when really necessary.

Drug interaction

Increased carbamazepine levels have been reported when used simultaneously with Cefixim.

The false positive cooom test has been reported while treating with other cephalosporin antibiotics, so it should be realized that positive cooom test may be due to drugs.

Anticoagulants: There has been a report to increase prothrombine time after using Cefixim simultaneously with anticoagulant drugs (such as warfarin).

Storage

Leave a cool place, avoid light, temperature below 30⁰C.

To be out of reach of children.

Other drugs

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