My Para 500mg S.P.M medicine supports fever analgesic (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen
Indication Fever
Contraindication Anemia

Ingredient

Thành phần cho 1 viên

Composition information	Content
Acetaminophen	500mg

Uses

Indications

Treatment of pain and fever from mild to medium.

Pharmacokology

Paracetamol (acetaminophen or N - acetyl - P - Aminophenol) is an active metabolic substance of phenacetin, an effective analgesic - antipyretic drug that can replace Aspirin; However, unlike aspirin, paracetamol is not effective for inflammation treatment.

With the equal dose calculated by grams, paracetamol has analgesic and fever -reducing effect similar to aspirin.

paracetamol reduces the body temperature in fever, but rarely reduces the body temperature in normal people. The drug acts on the hypothalamus causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow.

Paracetamol, with treatment dose, less impact on the cardiovascular and respiratory system, does not change acid -base balance, does not cause irritation, scratches or stomach bleeding as when using salicylate, because paracetamol does not act on cycloxygenase/protaglandin of the central nervous system. Paracetamol does not work on platelets or bleeding time.

When overdose of paracetamol, a metabolic substance is N - Acetyl - Benzoquinonimin that is toxic to the liver. Normal doses, paracetamol tolerated well, without many side effects of aspirin. However, acute overdose (over 10g) causes liver damage to death, poisoning and suicide with Paracetamol has increased worrying in recent years. In addition, many people including physicians, seemingly unaware of Paracetamol's poor anti -inflammatory effects.

Pharmacokinetics

absorption

Paracetamol is quickly absorbed and almost completely through the gastrointestinal tract.

Peak concentration in plasma reaches 30 - 60 minutes after drinking with treatment.

Distribution

Paracetamol is distributed quickly and evenly in most body tissues. About 25% Paracetamol in the blood combined with plasma protein.

Elimination

The semi -discharged time of paracetamol plasma is 1.25 - 3 hours, which can last for toxic doses or in patients with liver damage.

After the treatment dose, 90 to 100%of the urine can be found on the first day, mainly after the liver combination with glucuronic acid (about 60%), sulfuric acid (about 35%) or cysteine (about 3%); Also detects a small amount of hydroxyl metabolites - chemical and reducing acetyl. Children are less likely to glucuro than drugs than adults.

paracetamol is n - hydroxylation by cytochrom P450 to create 2n1ee acetyl benzoquinonimin, an intermediate with high reaction. This metabolic substance normally reacts with sulfhydryl groups in glutathion and thus deducted activity.

However, if you take high doses of paracetamol, this metabolic is formed in sufficient amount to exhaust the glutathion of the liver, in that situation, its reaction to the sulfhydryl group of the liver protein increases, which can lead to liver necrosis.

Before taking My Para 500mg S.P.M medicine supports fever analgesic (10 blisters x 10 tablets)

Always consult a doctor or pharmacist before deciding to take the drug.

How to use

Take oral use.

Dosage

To reduce pain or reduce fever: every 4-6 hours of drinking.

Adults and children over 12 years: take 1 tablet/time; Not more than 4 times/24 hours.

Children from 6 to 12 years old: 1/2 - 1 tablet/time; Not more than 4 times/24 hours.

Duration of use: Do not use paracetamol for more than 10 days in adults or more than 5 days in children when arbitrarily treating pain or reducing fever.

What to do when overdose?

Expression

Paracetamol poisoning may be due to a single -dose, or due to a large dose of paracetamol (for example, 7.5 - 10g a day, for 1-2 days), or for long -term medication. Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Nausea, vomiting, and abdominal pain usually occur within 2-3 hours after taking the poison of the drug. Methemoglobin - Blood, leading to purple blue, mucous and nails are a specific sign of acute poisoning P - Aminophenol; A small amount of sulfhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, it may initially stimulate the central nervous system, agitated and delirious. Next can be inhibiting the central nervous system; Stunned, lower body temperature, tired; Breathing fast, shallow; fast, weak, uneven circuit, low blood pressure; and circulation.

Vascular collapse due to relative hypoxia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of circuit drops.

Choking convulsions may occur. Often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage become clearly within 2 to 4 days after taking toxic doses. Aminotransferase plasma increases (sometimes very high) and the concentration of bilirubin in plasma can also increase further, when the liver lesions spread, the long prothrombin time.

Maybe 10% of patients with untreated poisoning have serious liver damage, out of which 10% to 20% finally die from liver failure. Acute renal failure also occurs in some patients. Liver biopsy detects central necrosis subtracting the area around the portal vein.

In cases of non -death, liver lesions recover after weeks or months.

Treatment

Early diagnosis is important in the treatment of paracetamol overdose. There are methods to quickly determine the concentration of drugs in plasma. However, do not postpone treatment while waiting for the test results if the history suggested that the overdose is severe. When severe poisoning, it is important to treat positive support.

Need to wash the stomach in any case, preferably within 4 hours after drinking.

The main detoxification is the use of sulfhydryl compounds, perhaps partly due to the addition of glutathion reserves in the liver. N - Acetylcystein works when taken or intravenously. Must give the drug immediately if less than 36 hours after taking paracetamol.

Treatment with N - Actylcystein is more effective when giving the drug for less than 10 hours after taking paracetamol. When drinking, dilute N - Acetylcystein solution with water or drink without alcohol to achieve a 5% solution and must be taken within 1 hour after mixing.

Give N - Acetylcystein at the first dose of 140mg/kg, then give 17 more doses, each dose of 70mg/kg 4 hours apart. Termination of treatment if the paracetamol test in plasma shows the risk of low liver toxicity.

The unwanted effect of N - Acetylcystein includes skin rash (including urticaria, no need to stop the drug), nausea, vomiting, both melting, and anaphylactic reaction.

If there is no N - acetylcystein, methionine can be used. Also can use activated carbon and/or salt bleach, they have the ability to reduce the absorption of paracetamol.

Notice immediately to the doctor the unwanted effects encountered when using an overdose.

What to do when you forget the dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Do not drink twice as prescribed.

Side Effects

When using the drug, you may experience unwanted effects such as:

skin rash and other allergic reactions occasionally occur are usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. People who are sensitive to rare salicylate sensitive to paracetamol are related drugs.

Uncommon, 1/1000

DA: Ban.

stomach - intestines: nausea, vomiting.

Hematology: Dehydration (neutropenia, all bloody hemorrhage, leukopenia), anemia. kidney: kidney disease, kidney toxicity when abusing for a long time.

Rare, ADR

Other: Hypersensitivity reaction.

Notice to the doctor the unwanted effects when using the drug.

If unwanted effects occur, stop using paracetamol. Regarding treatment, please read the section: "Overdose and handle".

Warnings

Contraindicated

contraindicated drugs in the following cases:

Patients with anemia many times or heart, lung, kidney or liver disease.

Personal hypersensitivity to paracetamol.

Patients with glucose deficiency - 6 - phosphate dehydrogenase.

Be cautious when taking the drug

paracetamol is relatively non -toxic to the dose of treatment. Sometimes there are skin reactions including itchy and urticaria, other sensitive reactions including larynx edema, angioedema, and anaphylactic reactions that may rarely occur. Platelets, leukopenia, and all blood cells have occurred with the use of P - Aminophenol substances, especially when used for large doses. Neutral leukopenia and thrombocytopenic hemorrhage occur when using paracetamol. Rarely loss of granulocytes in patients using paracetamol.

Must use paracetamol carefully in anemic anemia, because purple blue may not manifest clearly, although there are dangerous high concentrations of methemoglobin in the blood.

Drinking plenty of alcohol can increase the toxicity of Paracetamol's liver; Should avoid or limit drinking.

Do not use paracetamol to treat pain for more than 10 days in adults or more than 5 days in children, unless the physician is instructed, because of such a lot of pain and prolonged pain may be a sign of a pathological condition that needs a physician to diagnose and supervise.

Do not use paracetamol for adults and children to treat high fever by themselves (above 39.5 ° C), fever lasts for more than 3 days, or a recurrent fever, unless it is instructed by a physician, because such a fever shows signs of a serious illness that needs to be diagnosed quickly by a physician.

Doctors need to warn patients on signs of serious skin reactions such as Steven - Jonhson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustules syndrome (AGEP).

The ability to drive and operate machinery

does not affect the operation of machinery and trains.

pregnancy and lactation

Pregnant people

The safety of paracetamol has not been determined during pregnancy. Therefore, Paracetamol should only be used in pregnant women when needed.

breastfeeding

Research in the mother using paracetamol after lactation does not see unwanted effects in breastfeeding.

Drug interaction

Long -term oral high doses of paracetamol increases the anticoagulant effect of COMAARIN and indandion derivatives. This effect seems less or not clinically important, so paracetamol is preferred than salicylate when it is necessary to relieve mild pain or reduce fever for patients who are using cooumarin or indandion derivatives.

It is necessary to pay attention to the possibility of serious antipyretics in patients using phenothiazine and antipyretic therapy.

Out of alcohol too much and long can increase the risk of paracetamol toxic to the liver.

Anti -convulsions (including Phenytoin, Barbiturat, Carbamazepin) that causes enzyme induction in the liver microsom, can increase the toxicity of the liver toxicity of paracetamol due to increased drug metabolism into toxic substances to the liver. In addition, simultaneous use of isoniazid with paracetamol can also lead to an increase in the risk of toxicity to the liver, but it has not been determined the exact mechanism of this interaction. The risk of paracetamol causes liver toxicity significantly increases in patients with paracetamol doses greater than the recommended dose while taking anti -convulsions or isoniazid. Often do not need to reduce the dose in patients with simultaneous doses of paracetamol treatment and anti -convulsions, but patients have to limit their own Paracetamol self -use while taking anti -convulsions or isoniazid.

Storage

Store drugs at less than 30 ° C, leave a cool dry place, avoid direct light, moisture prevention.

Expiry date: 36 months from the date of manufacture.

Packaging:

10 tablets, boxes of 10 blisters.

bottle of 100 tablets, or 200 tablets or 500 bottles.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.