MY PARA 650mg S.P.M medicine supports fever analgesic (10 blisters x 10 tablets)

Dosage form Film bag tablets
Specifications Box of 10 blisters x 10 tablets
Ingredient Acetaminophen
Indication Sore throat, sinusitis, fever, cold, headache, migraine, body aches
Contraindication Anemia

Ingredient

Composition information	Content
Acetaminophen	650mg

Uses

Indications

MyPara 650 medicine is used in the following cases:

Symptoms of bone pain, low muscle pain (painful pains that are non -internal pain) and/or mild fever to medium fever. The drug acts on the central cashew center in the hypothalamus, causing cooling, increasing heat due to vasodilation and increasing peripheral blood flow reduces body temperature in the fever, but rarely reduces normal heat body.

Paracetamol does not have the effect of inflammation treatment.

With the dose of treatment, paracetamol metabolizes mainly through a suifate and glucuronid complex reaction. A small amount usually converts into a toxic metabolite, N-acetyl-P-Benzoquinonimin (NAPQI). Napqi is detoxified by glutathion and eliminated into urine and/or bile. When metabolites are not connected to glutathion, it will be toxic to liver cells and necrotic cells.

Paracetamol is often safe when used for treatment, because the amount of Napqi is formed relatively low and glutathion formed in liver cells that are sufficiently associated with NAPQI. However, when overdose or sometimes with the common dose used in some sensitive people (such as malnutrition, drug interaction, alcoholism, genetics), the concentration of Napqi can be accumulated in the liver.

pharmacokinetic

absorption

Paracetamol when taken will be absorbed quickly and completely. The peak concentration of plasma is about 10 - 60 minutes after drinking.

Distribution

fast and uniform in most body tissues, about 25% paracetamol in the blood combined with plasma proteins.

Metabolism

paracetamol is metabolized mainly in the liver in two main paths in the liver:

1) Combined with glucuronic acid and combined with sulfuric acid.

2) Combined with sulfuric acid quickly saturated when taking higher doses but still within the scope of treatment.

The saturation of the glucoronide process only appears when the doses are higher, toxic to the liver. A small part (less than 4%) is trips by cytochrom P450 to form a high reaction intermediate (N-acetyl Benzoquinoneimin), in normal use conditions, this intermediate will be detoxified by glutathion reduction and are eliminated in urine after being connected to cystein and mercapturic acid. However, when poisoning with high doses of Paracetamol, the amount of metabolites with this toxicity increases.

Elimination

Paracetamol metabolites are mainly eliminated in urine, in adults, about 90%of the dose is excreted for 24 hours, mainly in the form of glucuronid complex (about 60%) and sulfate complex (about 30%). Under 5% is eliminated in constant form. Selling time for plasma is about 2 hours.

Before taking MY PARA 650mg S.P.M medicine supports fever analgesic (10 blisters x 10 tablets)

How to use

MyPara 650 medicine is taken orally. Should drink during or after meals.

Dosage

Adults and children> 12 years old

Take 1 capsule/time, do not drink more than 6 tablets/day or as directed by the doctor.

Note:

The distance between 2 medications must be at least 5 hours.

Do not prolong the use of the drug on your own, but it is necessary to have a doctor's opinion when: a new symptom appears. High fever (39.5 ° C) and lasts more than 3 days or relapses. Painful and lasting more than 5 days.

What to do when overdose? Liver necrosis depends on the dose is the most serious toxic effect due to overdose and can be fatal.

Nausea, vomiting and abdominal pain usually occur within 2-3 hours after taking the poison of the drug. Methemoglobin - Blood, leading to purple blue, mucosal and nails are a characteristic sign of acute poisoning P -aminophenol; A small amount of sulfhemoglobin can also be produced. Children tend to create methemoglobin easier than adults after taking paracetamol.

When severe poisoning, it may initially stimulate the central nervous system, agitated, and delirium. Next can be inhibiting the central nervous system; Stunned, lower body temperature; tired; Breathing fast, shallow; fast, weak, uneven circuit; Low blood pressure; and circulatory failure. Validates due to relative hypoxemia and central inhibition effects, this effect only occurs in huge doses. Shock may occur if a lot of vasodilation. The suffocating convulsions may occur. Often coma occurs before dying suddenly or after a few days of coma.

Clinical signs of liver damage become clearly within 2 to 4 days after taking toxic doses. Aminotransferase plasma increases (sometimes very high) and the concentration of bilirubin in plasma can also increase; In addition, when the liver lesions spread, the long prothrombin time. It is possible that 10% of patients with untreated poisoning have serious liver damage; Among them 10% to 20% finally die from liver failure. Acute renal failure also occurs in some patients. The liver biopsy detects that the central necrosis of the urine except the area around the portal vein. In cases of non -death, liver lesions recover after weeks or months

Emergency treatment

In the hospital:

Bowel washing and drinking activated carbon. N-acetylcystein, methionine can be used. In addition, activated carbon and/or saltworm can be used, they have the ability to reduce the absorption of paracetamol.

help breathe. However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using MyPara 650, you may experience unwanted effects (ADR).

Skin rash and other allergic reactions occur. Usually erythema or urticaria, but sometimes worse and may be accompanied by fever due to drugs and mucosal lesions. Patients with susceptibility to rare salicylate sensitive to paracetamol and related drugs. In a few individual cases, Paracetamol has caused neutropenia, thrombocytopenia and all bloody hematoma.

rarely

Skin: Ban

Digestive: irritating stomach, nausea, vomiting.

Stevens-Johnson syndrome, lyell syndrome, poisoned epidermal necrosis, acute pustules rash, hypersensitivity reaction.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

MyPara 650 drug is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Caution when using

If the pain lasts more than 5 days or a fever lasts more than 3 days or if the drug is not effective or any other symptoms occur, do not continue treatment without consulting your doctor.

Be careful in patients with anemia before, impaired liver and kidney function. Overdose or long -term treatment can cause liver necrosis, kidney failure.

Drinking plenty of alcohol can cause toxicity to the liver of paracetamol, should avoid or limit drinking.

For Paracetamol-containing drugs: Doctors need to warn patients on signs of serious skin reactions such as Steven-Johnson syndrome (SJS), toxic skin necrosis syndrome (Ten) or Lyell syndrome, acute pustular syndrome (AGEP).

The ability to drive and operate machinery

The drug does not cause dizziness, drowsiness, so it can be used for people who are driving and operating machinery.

Pregnancy

only use drugs for pregnant women when really necessary.

Breastfeeding period

Medicine interaction

long -term oral doses of high doses Paracetamol increases the anticoagulant effect of COUMARIN and derivatives.

It is necessary to pay attention to the possibility of serious heat lowering the patient and phenothiazine and cooling (such as paracetamol).

Anti -seizure drugs (Phenytoin, barbiturat, carbamazepin), isoniazid increases the toxic liver toxic of paracetamol.

Probenecid may reduce paracetamol elimination and increase the half -life of plasma of paracetamol.

Isoniazid and anti -tuberculosis drugs increase the toxicity of paracetamol for the liver.

metoclopramid, domperidon increases the absorption speed of paracetamol, cholestyramin reduces the absorption rate of paracetamol.

Out and long -term drinking increases the toxicity on the liver of paracetamol.

Storage

Leave a cool place, avoid light, temperature below 30 ° C.

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