Mynoline Cophavina medicine for infection treatment (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Minocyclin

Ingredient

Composition information	Content
Minocyclin	100mg

Uses

indications

Mynoline drugs are indicated in the treatment of bacterial diseases caused by sensitive gram and gram -negative bacteria.

Supplemented treatment of acne infections does not respond to tetracyclin or erythromycin.

Gonorrhea (chlamydia trachomatis or ureaplasma ureaticum).

The good person carrying N. Meningitidis has no symptoms, but there are now many antibiotics recommended such as Ceftriaxon, Ciprofloxacin.

Gonorrhea and coordinated infection.

Syphilis: Minocyclin is a penicillin replacement therapy in adults and children over 8 years old, not pregnant women are allergic to penicillin.

Diseases caused by bacillus Mycobacteria: Adult leprosy can not use rifampicin due to allergies or anti -rifampicin bacteria or non -tolerance of clofazimin. Leprosy in children with little single bacteria. Minocyclin is also used to treat skin infections caused by M Marinum.

Cholera.

Nocardia bacterial infections.In addition, minocyclin is also used to treat rheumatoid arthritis.

Pharmacokic

ACT code: J01A A08 - Antibiotics of Tetracyclin group.

Minocyclin hydrochlorid is a broad -spectrum antibiotic and the same mechanism of action with TCTRACYCLIN but Mintycline also works with many bacterial strains including ST. Aureus, strains of Streptococci, N. Meningitidis, Acinetobacter, Bacteroides, Heamophylus, Nocardia, many intestinal bacilli, some types of Mycobhacteria, in due to M. Leprae.

The mechanism of action is like tetracyclin: The drug is attached to the position of 30S of ribosom and inhibits the ribosom function of bacteria, thus inhibits the bacterial protein synthesis according to the mechanism to prevent the aminoacyl T-RNA attachment process.

Minocyclin is more fat than Doxycyclin and other tetracyclin: has a higher affinity for adipose tissue thus enhances the efficiency and changes of the gums. Stomach irritation and bacterial disorders are less than water drugs.

There is a cross -sectional resistance between minocyclin and other tetracyclin, but a number of strains, although resistant to other TCTRACYCLINs, are still sensitive to minocyclin. The MINOCYCLIN mechanism has better cell membranes

Effects on rheumatoid arthritis: The mechanism of action of the drug in rheumatoid arthritis is not well understood. The assumption is that minocyclin has antibacterial anti -inflammatory, immune air conditioning and mitochondria. Moreover, minocyclin is allowed to inhibit metalloproteinase - a substance that destroys joints in rheumatoid arthritis.

Pharmacokinetics

absorption

Minocyclin is quickly absorbed by oral with about 90-100% of oral dose absorbed when drinking hungry. The peak concentration of serum is achieved after drinking 1-4 hours, an average of 2.4 hours. After taking the initial dose of 200mg minocyclin, the next dose 100 mg per 12 hours, the concentration of the noise serum is 2,3-3.5microgam/ml.

Do minocyclin is prone to chelming by valence cations 2 and 3 such as calcium, iron, aluminum, magnesium so oral antacids containing these cations can reduce the absorption of the drug. When taken with a meal or with an average amount of milk, the absorption of minocyclin is affected by speed and level. In adults when minocyclin tablets or capsules with meals with dairy products will reduce CMAX 11-12% and TMAX lasts more than 1 hour than drinking when hungry with water. If used with milk, the drug of the drug will decrease by about 27%.

Distribution

The drug is associated with plasma proteins about 70-75%, well diffused into tissues and fluids such as tonsils, bronchi, lungs, fairy glands, bile, bile, liver, female genital tract, kidney muscles-urinary tract as well as in saliva, surface water, sputum with higher concentration than the minimum inhibitory concentration of common cable causes infections of these organs. The drug accumulates in adipose tissue, organs and half -life for prolonged elimination leading to an increased risk of unwanted effects when treatment lasts for a long time, even when low doses. The drug penetrates into the cerebrospinal fluid relatively poorly. The drug through the placenta and excretion into breast milk. For example, from 0.14 to 0.70 liters/kg.

Metabolism

The drug is partially metabolized in the liver into about 6 inactive chemicals, mainly 9-hydroxylylinocyclin.

Elimination

In adults with normal kidney function, about 4-19% of oral doses are eliminated through pepper water and 20-34% are eliminated in feces within 72 hours in the active drug form. Half of the half -life of 11 - 26 hours in people with normal kidney function. Patients with liver dysfunction this index is 11 -16 hours. Patients with severe renal impairment of the drug's waste time lasts longer, leading to the risk of accumulation. Dialysis outside the kidney has little effect to eliminate minocyclin.

Before taking Mynoline Cophavina medicine for infection treatment (3 blisters x 10 tablets)

How to use

take mynoline medicine with lots of water and in a standing or sit to reduce the risk of irritation or esophageal ulcer. Drink away from meals (1 hour before or 2 hours after eating).

antacids. Bodhi calcium, iron, laxatives containing magnesium and cholestyramin must take 2 hours compared to Mynoline.

Dosage

Adults: Treatment of infections, initial dose is 200mg, then 100mg/12 hours. Can split the dose: initially 100 - 200mg, then 50mg/time x 4 times/day.

Children over 8 years old: initial dose is 4mg/kg, then 2mg/kg/12 hours.

Treatment dose of a specific case:

Caviar treatment: 50mg/time, 2-3 times a day.

Chlamydia infection or ureaplasma ureaticum: 100mg/12 hours for at least 7 days.

Inventid illness of gonorrhea: dose of 100mg/12 hours for at least 5 days.

Gonorrhea urethritis: 100mg/12 hours in 5 days.

infection N. meningitidis as symptoms: 100mg/12 hours in 5 days.

Infections caused by Nocardia family: The usual dose of minocyclin in combination with sulfonamide for 12 - 18 months.

rheumatoid arthritis: 100mg/12 hours in 1 - 3 months.

Syphilis: 100mg/12 hours for 10 - 15 days.

Cholera infection: initial dose 200mg, then 100mg/12 hours for 48 - 72 hours.

Leprosy: Worms of many bacteria cannot be treated with rifampicin: 100mg/day in combination with other leprosy drugs (clofazimin 50mg/day, ofloxacin 400mg/day) in 6 months of attack, followed by 18 months with minocyclin 100mg/day and clafazin 50mg/day. For many bacteria that cannot be treated with clofazimin: 100mg minocyclin/time/month in combination with ofloxacin 400mg/time/month and rifampicin 600mg/time/month for 24 months. Lessly lesions of lesions: The only dose of 60mg rifampicin, 400mg ofloxacin and 100mg minocyclin.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Specific antagonist of minocyclin is currently unknown.

In case of overdose, stopping drugs and symptomatic treatment, combined with supportive treatment. Hematopathy does not eliminate significant minocyclin.

In an emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

There is no information on the frequency of the ADR, often the following ADR:

Cardiovascular disease: myocarditis, pericarditis, capillary inflammation.

Central nervous system: Having benign intracranial pressure (fake brain syndrome), dizziness, fatigue, headache, relieving sensation, mood changes, convulsions, drowsiness, loss of balance.

Skin and hair: Hair loss, angioedema, pink roses are diverse in chromosomes, urticaria, redness, scales, dark nails, sensitive to light, tanning and mucous membranes, Steven-Johnson syndrome, poisoned epidermal necrosis.

Endocrine and metabolism: Hypothyroidism.

Digestive: Anorexia, not delicious, disruptive tooth enamel, diarrhea, vomiting, bowelitis, esophagitis, oral mucosa, vomiting, pancreatitis, fake colitis due to proliferation C. Difficile.

Urinary tract: Gulpedia, urethritis.

Hematology: A decrease in granulocytes, acidic leukemia, reduction of leukemia, neutropenia, thrombocytopenia, reducing blood cell lines.

liver: increased transaminase, hepatitis, liver failure, hyperpladier blood bilirubin, bile obstruction, jaundice.

Neuropathy - bone: arthritis, joint pain, stiffness, decreased sensation, dental development disorders.

Eyes: blurred vision.

Kidney: Acute renal failure, hypernoding non -protein nitrogen, interstitial nephritis.

Respiratory: Hen, bronchospasm, cough, shortness of breath, interstitial pneumonia infiltrated Eosin.

Autoimmune syndrome: Long -term treatment with minocyclin can lead to systemic erythematosus syndrome due to drugs, autoimmune hepatitis, inflammation, serum disease.

Other: Anaphylaxis, enamel minority, yellow or brown teeth.

Instructions on how to handle ADR:

Fake colitis: Mild cases may end, in medium and severe cases of water and electrolytes, protein supplements, antibiotic treatment with force with C. Difficile.

Autoimmune syndrome: Before treatment, it is necessary to test with antibody antibodies, monitor this test during treatment for early detection, stopping the drug as soon as there is a diagnosis of autoimmune by minocyclin.

Sensitive to light: Limit exposure to sunlight and artificial light with UVA/UVB during medication treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

MYNOLINE drug contraindicated in the following cases:

Hypersensitivity to antibiotics Tetracyclin or ingredients of the drug.

Be cautious when using

as well as other tetracyclin antibiotics, minocyclin can be dangerous to the fetus. If the drug is used during pregnancy or a patient who is pregnant during treatment with this drug, this group needs to warn the patient about the risk of the fetus. The use of Tetracyclin medication affects the development of the teeth (at the end of pregnancy, babies and children under 8 children) causes permanent teeth coloring.

This side effect is common when prolonged use also occurs in the case of a short regimen. Reducing enamel production is also reported. Therefore, only tetracycline is used in the development of teeth when contraindicated with other drugs or other drugs ineffective.

All tetracycline antibiotics formed durable with calcium in bone tissue. Reducing the growth rate of the bone has been reported in premature babies when giving tetracyclin at a dose of 25mg/kg every 6 hours. This reaction is recovered after the drug stopped.

Animal studies show that tetracyclin through the placenta, found in the fetal tissue and can be harmful to the fetal development (often slowing the skeletal system development process). There is evidence of toxic to embryos in experimental animals during the first time of pregnancy.

The rash caused by drugs accompanied by eosin leukemia and systemic symptoms (dress) including deaths were recorded when using minocyclin

If this symptom is detected, it is necessary to stop the drug immediately.

Inhibiting the assimilation of Tetracyclin can cause Bun

For people with normal kidney function, this effect is not worrying but for patients with kidney failure. Increased blood tetracyclin levels can lead to hyperur with hemorrhage, blood phosphate and metabolic acidosis. In such a case, it is necessary to monitor the level of creatinine and bun and the total dose of the drug must not exceed 200mg/day. If the patient has kidney failure, even at the level of oral or common injection can lead to drug accumulation and toxic to the liver

The hypersensitivity reaction to light has been recorded with some cases of tetracycline antibiotics including minocyclin.

Side effects with the central nervous system including mild, dizziness have been recorded when using minocyclin. Patients need to be warned if operating machinery or driving when taking the drug. This side effect may be eye -catching during the use of the drug or after the treatment.

diarrhea caused by C.dificile has been reported to most antibiotics including minocyclin.

As with other antibiotics, the use of drugs can increase fungi that is fungus. If the superinfection occurs, it is necessary to stop treating with antibiotics and find another appropriate regimen.

Benigned intracranial pressure has been received when using tetracyclin. Clinical symptoms are usually headaches, blurred vision. The fontanel room has been recorded in children when using tetracyclin. Although the symptoms will go away after stopping the drug, the risk of sequelae can still occur.

Poisoning with the liver has been recorded when using minocyclin; Therefore, it is necessary to be cautious when taking the drug for these patients or combined with other risks to toxic to other liver.

The effect of the drug on the ability to drive and operate machinery

Patients should be warned of the risk of occurring when driving or operating the machine because the drug can cause dizziness, headache, loss of air conditioning.

Use drugs for women during pregnancy and lactation

pregnancy:

There is no adequate and controlled research on the use of minocycline for pregnant women. Like other tetracyclin antibiotics, minocyclin passes the placenta and can be dangerous for the fetus if used for women during pregnancy. A few reports recorded cases of birth defects such as expenditure reduction. Only a small amount of information is not enough evidence to conclude about the cause of the results. If using minocycline during pregnancy or pregnant patients during the treatment with minocyclin, the patient should be warned of this risk to the fetus.

breastfeeding period:

Tetracyclin is excreted in breast milk. Due to the risk for breastfeeding, it is necessary to consider the benefits of the drug and continue breastfeeding.

Interactive drug

Because Tetracyclines antibiotics reduce prothrombin activity, patients taking anticoagulant drugs may have to reduce the dosage of drugs that are used quickly.

Do not use in combination with penicillin groups due to interaction on the mechanism of action of these two antibiotic groups.

The absorption of the drug is affected by drugs containing calcium or magnesium and iron.

Concomitance Tetracycline with methoxyflurane may lead to death from kidney poisoning

Concentrated with oral contraceptives reduces the effectiveness of birth control pills

Using with Isotretinone to stop before and after the regimen with minocycline

Risk of barley alkaloid poisoning when used simultaneously with tetracyclin.

Catecholamine concentration in fake urine can occur due to minocyclin use.

Storage

In a dry place, avoid light, temperature below 30 ° C.

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