MYOPAIN 50 Stella Medicine Treatment of Muscle Spastic Sagine (5 blisters x 10 tablets)

Dosage form Box of 50 capsules
Specifications Tolperisone hydrochloride

Ingredient

Composition information	Content
Tolperisone hydrochloride	50mg

Uses

indications

Myopain 50 medicine is indicated in the following cases:

Treatment of symptoms of spasticity after stroke in adults.

Pharmacology

Tolperisone Hydrochloride is a central -acting muscle relaxant. The drug has a complex mechanism of impact. By sustainable and local anesthesia, Tolperisone inhibits the transmission in the nerve fibers towards the mind and movement neurons, thereby inhibiting SYNAP and SYNAP single reflexes.

On the other hand, according to a second mechanism, through the inhibition of Ca2+ inhibitors through synap, the inhibitor of neurotransmitter release neurotransmitters. In the brain body, Tolperisone inhibits grid -spinal cord reflection.

Tolperisone improves peripheral circulation. This useful effect does not depend on the effects seen on the central nervous system, which may be related to the anti -slight spasm and the tolperisone's adrenergic resistance.

Pharmacokinetics

absorption

Tolperisone is well absorbed through the small intestine after drinking. Fat -rich meals can increase the bioavailability of oral tolperisone up to 100% and increase the peak concentration in plasma about 45% compared to snacks. The peak concentration reaches about 30 minutes after drinking.

Metabolism

Tolperisone is strongly metabolized through the liver and kidneys.

Elimination

This compound is excreted mainly through the kidney (more than 99%) in the form of metabolites.

Before taking MYOPAIN 50 Stella Medicine Treatment of Muscle Spastic Sagine (5 blisters x 10 tablets)

How to use

Myopain is an oral medication during or after meals.

Dosage

Adults

Common dose: 50 - 150 mg x 3 times/day.

Children

The safety and effectiveness of Tolperisone in children has not been confirmed.

Other objects

Information about the use of drugs in patients with renal impairment is limited, but it has recorded an increase in the occurrence of harmful events in this group of patients. Therefore, for patients with average renal impairment, the dosage is needed for each patient in combination with closely monitor the condition and kidney function. It is not recommended to use Tolperisone in patients with severe renal failure.

Information about the use of drugs in patients with hepatic impairment is limited, but it has recorded an increase in the occurrence of harmful events in this group of patients. Therefore, for patients with medium degrees of liver failure, the dosage should be determined for each patient in combination with closely monitor the condition and liver function. It is not recommended to use Tolperisone in patients with severe liver failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when using overdose? Tolperisone has no specific antidote. In case of overdose, supportive treatment and symptomatic treatment.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double dose to compensate for missed dose.

Side Effects

When using Myopain 50 medicine, you may experience unwanted effects (ADR).

Systemic: Hypersensitivity reaction. Most reactions are not serious and can recover. Very rare life -threatening reactions.

Rare, 1/10000

Body: confused, increased sweating.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Myopain 50 drug contraindicated in the following cases:

Hypersensitivity to Tolperisone, substances with chemical structures similar to Eperison or excipients.

heavy myasthenia.

Be cautious when using

Hypersensitivity reactions:

After circulating on the market, the most harmful reaction reported about Tolperisone is hypersensitivity reactions, manifested from mild skin reactions to heavy body reactions such as anaphylaxis. The possible manifestations include rash, redness, sewing, itching, angioedema, fast vessels, hypotension, shortness of breath.

The risk of hypersensitivity reactions is usually higher than in women, patients with a history of allergies or a history of hypersensitivity to other drugs.

Be careful when using Tolperisone in patients with lidocaine sensitivity due to cross -reaction.

Patients should be recommended for the possibility of hypersensitivity reactions when using Tolperisone, when there is any hypersensitivity, stop immediately and quickly consult a doctor.

No reuse Tolperisone for patients who have had too hypersensitivity to Tolperisone.

The ability to drive and operate machinery

If you experience dizziness, sleep, distraction, epilepsy, blurred vision, or weakness when taking Tolperisone, patients need to consult a doctor's advice.

Pregnancy

Because there is no appropriate clinical data, it is not advisable to use Myopain for pregnant women (especially in the first 3 months of pregnancy), unless the expected benefits of the drug are certainly higher than any toxicity that may occur with embryos.

Breastfeeding period

Because it is not known whether Tolperisone is excreted through breast milk or not, should not use Myopain during breastfeeding.

Drug interaction

Studies of pharmacokinetics interactive on the metabolic enzyme CYP2D6 with dextromethorphan substrate show that Tolperisone simultaneous use may increase the blood concentration of the medication mainly through CYP2D6 such as Thioridazin, Tolterodin, Venlafaxin, Desillpramin, Dextromethin, Dextromethine Metoprolol, nebivolol, perphenazin.

In vitro studies on liver lobes and human liver cells do not show any inhibition or induction on other ISOENZYM CYP (CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP1A2, CYP3A4).

In contrast, Tolperisone concentration is not affected when used simultaneously with medications metabolized through CYP2D6 because Tolperisone can metabolize other roads.

Tolperisone's bioavailability is reduced if not taken with a meal, should take medicine with meals or immediately after eating.

Tolperisone is a central -acting muscle relaxant with little sedative effect.

In case of simultaneous use of Tolperisone along with other central -acting muscle relaxants, tolperisone dose should be considered if necessary. Tolperisone may increase the effects of niflumic acid, so it is important to consider reducing the dose of niflumic acid or other NSAIDs when used simultaneously with Tolperisone.

Storage

Store in closed packaging, dry place, avoid light. The temperature does not exceed 30 ° C.

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