Nadygenor 5ml Nadyphar drugs for maintenance of hypernigs with blood ammonia (20 tubes)

Dosage form 20 tube box
Specifications Arginin aspartat

Ingredient

Composition information	Content
Arginin aspartat	1g

Uses

indications

nadygenor drugs are indicated in the following cases:

Treatment of maintenance of blood ammonia in patients with carbamylphosphate synthetase deficiency, lack of ornithin carbamyl transferase. Good ability to practice in people with stable cardiovascular disease.

Arginin is like other amino dibasic acids, stimulating the pituitary glands to release growth hormones and prolactin, pancreatic snow release glucagon and insulin.

Arginin is a major amino acid in the urea cycle when the N-acetylglutamat Synthase (NAGS), Carbamyl Phosphate Synthetase (CPS), Ornithin Transcarbamylase (OTC), Arginininsuccinat Synthetase (ASS), either ASSSCINATLY (ASL).

arginine increases blood glucose levels. This effect may be directly. Glycogen decomposition and glucose creation can also be through arginin intermediaries stimulating glucagon release.

The serum gastrin concentration is enhanced by arginin.

Competition inhibitors of the renal tubules and thus increases the excretion of protein in the urine including albumin, light chain Immunoglobulin and beta2 microglobulin.

Mechanism of action:

The effect of arginin stimulates growth hormone, prolactin, glucagon and insulin does not depend on adrenalin release control and changes in blood glucose levels. Arginin stimulates the release of growth hormones and prolactin of the pituitary gland may be acting on the hypothalamus. In patients with normal peaceful gland function, plasma growth hormone levels increased after using arginine, and in patients with reduced pituitary function, growth hormone increased very little or no increase.

Arginin can be used in the form of: hydrochloride, acetylasparaginat, aspartat, citrate, glutamate, oxoglurat, tidiacicat, Timonacicate.

Aspartat:

Salt form of aspartic acid.

Aspartic acid usually exists in the form of L (-) are non-essential amino acids in animals and plants, especially in young sugarcane and sugar beets, used to supplement the diet.

Dynamic pharmacokinetics

arginin aspartat absorb good through the gastrointestinal tract. Strong metabolic drugs in the liver, forming orthinine and urea through the hydrolysis of Guanidine under the catalysis of arginase. Arginin is filtered in the renal tubules and is absorbed almost completely in the renal tubules. Half lifetime elimination: 1.2 - 2 hours.

Before taking Nadygenor 5ml Nadyphar drugs for maintenance of hypernigs with blood ammonia (20 tubes)

How to use

Used under the supervision of the specialist.

Used orally. He is diluted with a little water, drinking before meals.

Dosage

Maintain blood ammonia in patients with carbamylphosphate synthetase, ornithin carbamyl transferase:

Infants: 100 mg/kg per day, divided 3-4 times.

infant: 100-175 mg/kg/time; Use 3-4 times a day with food, adjust the dose according to the response. Use 3-4 times a day, with food, adjust the dose according to the response.

Adults: Take 3-6 g/day.

Adults: Take 6-21 g/day, each use no more than 8g.

Adults: Take 3-20 g/day depending on the condition.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What to do when overdose?

Stomach washing, symptomatic treatment and support.

A suitable antihistamine should be used for allergic reactions.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using Nadygenor you may experience unwanted effects (ADR):

Common: Numbness, headache. Nausea, vomiting. Increase body temperature.

Other effects: flushing, local vein stimulation may occur.

Rare: edema, redness, pain. Reduce platelets. Anaphylactic reaction.

Unknown frequency: lower blood pressure, intravenous inflammation. Abdominal muscles with abdominal distention in patients with cirrhosis. Causing growth hormone, insulin, glucagon, prolactin. Hypotension in people with liver, kidney, diabetes. Reducing blood phosphorus in diabetes patients. Increased urea nitrogen level and serum creatinine.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Nadygenor drugs contraindicated in the following cases:

Hypersensitivity to arginin aspartat or any ingredient of the drug.

Be cautious when using

need to be very careful when taking the drug for patients in the following cases:

In patients according to the sugar diet, it should be noted in each tube containing 1 gram of white sugar. Bicarbonate. Glucose-Galactose or Sucrase-Isomaltase disorders should not use this medication.

The effect of the drug on the ability to drive and operate machinery

Due to the unwanted effect in the central nervous system such as numbness, headache, when using the drug, it is not allowed to drive and operate machinery.

Using drugs for women during pregnancy and lactation

Using drugs for pregnant women:

There is no complete and well -verified research on the use of arginin in pregnant women, so they do not use this drug for women during pregnancy.

Use medicine for breastfeeding women:

It is unknown whether the arginin is secreted in a significant amount in human milk or not. It is necessary to consider the benefits of treatment with drugs and the risk of fetus to decide the use of drugs and stop breastfeeding.

Interactive drug

Estrogen and progestrogen combined medications may increase the response of growth hormones and reduce the response of glucagon and insulin with arginin.

Insulin concentration in plasma after arginin stimulation can be increased by diurotic thiazid, xylitol and aminophylin.

xylitol and aminophylin reduces the response of glucagon with arginin.

Sulfonylura long -term use, oral diabetes, can prevent glucagon response in plasma with arginine.

Phenytoin reduces insulin response in plasma with arginin, when patients do not tolerate glucose intolerant to glucose.

Patients who use diuretics to reduce potassium consumption are at high risk of hyperkalemia caused by arginine, thus avoid combining these drugs.

The cavalry of the drug: due to the absence of studies on the correlation of the drug, not mixing this drug with other drugs.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

Other drugs

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.