Nakai 300mg Davipharm drugs treat sensitive infections (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Clindamycin

Ingredient

Composition information	Content
Clindamycin	300mg

Uses

indications

Nakai drug are indicated in the following cases:

Prevention pericardial inflammation or surgical transplant infections for patients allergic to penicillin or patients who have been treated for a long time with penicillin. Bacteria in the abdomen such as peritonitis and abscess in the abdomen. gas. The effect of clindamycin is to link to the mini of the ribosome part, thus inhibiting the bacterial protein synthesis. Clindamycin has a bactericidal effect at low concentrations and bactericidal at high concentrations.

Bacterial resistance mechanism for clindamycin is methylation RNA in the mini part of the ribosome part of bacteria. This type of resistance is usually through plasmid intermediaries. There is a cross -resistance between clindamycin and erythromycin, because these drugs act on the same position of bacterial ribosome.

In vitro effects of clindamycin for the following bacteria:

Glass Gram -positive bacteria: Staphylococcus aureus, Staphylococcus Epidermidis, Streptococcus (except for S. Faecalis), Pneumococcus.

Aerobic gram bacillus: Bacteroides (B. Fragilis) and Fusobacterium spp.

Anaerobic Gram -positive bacillus: Propionibacterium, eubacterium and Actinomyces spp.

Anaerobic gram -positive bacteria: peptococcus and peptostreptococcus spp., Clostridium perfringens (except C. Sportogenes and C. Tertium).

Other bacteria: Chlamydia trachomatis; Toxoplasma Gondii, Plasmodium Falciparum, Pneumocystis Carinii, Gardnerella Vaginalis, Mycoplasma Brominn.

The following bacteria are often resistant to clindamycin: Aerobic gram -negative bacillus; Streptococcus Faecalis; Nocardia sp; Neisseria meningitidis; Staphylococcus aureus resistant to methicillin; Haemophilus influenzae.

Pharmacokinetics

absorption

Clindamycin can be taken for sustainable in the acidic environment. Minimum inhibitory concentration: 1.6 micrograms /ml.

About 90% of the oral dose of Clindamycin Hydrochloride is absorbed.

After taking 150, 300 and 600 mg (according to clindamycin), the corresponding plasma peak concentration is 2–3 micrograms/ml, 4 and 8 micrograms/ml for 1 hour.

When 300 mg of clindamycin phosphate is intramuscularly every 8 hours, the plasma peak concentration reaches about 6 micrograms/ml for 3 hours.

Plasma peak concentration is 10 micrograms/ml when infusion of 600 mg of clindamycin phosphate in 20 minutes every 8 hours.

Distribution - Metabolism

In vivo, clindamycin hydrochloride quickly hydrolyzed into clindamycin.

Clindamycin is widely distributed in the body's fluid and tissue, including bone, but the distribution does not achieve significant concentrations in cerebrospinal fluid. More than 90% clindamycin binds to plasma proteins.

Elimination

The sale time of the drug is 2–3 hours, but can last in infants and patients with severe renal impairment.

About 10% of oral medications are excreted in urine in the form of activity or metabolites and about 4% excreted in feces.

Age does not change the pharmacokinetics of clindamycin if normal liver and kidney function.

Before taking Nakai 300mg Davipharm drugs treat sensitive infections (3 blisters x 10 tablets)

How to use

Nakai drug Used orally.

Dosage

Treatment time with clindamycin depends on the type of infection and severe severity of the disease.

In infections due to blood -solted Beta hemolysis streptococcus, clindamycin treatment must continue at least 10 days. In severe bacterial infections such as pericarditis or osteoarthritis, at least 6 weeks of treatment.

The drug is used at a dose of 150–300 mg of clindamycin, every 6 hours; The dose of 450 mg, every 6 hours is seriously infected.

Children: 3–6mg/kg, every 6 hours.

Children under 1 year of age or weight under 10 kg used 37.5 mg, 8 hours.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when overdose? Use anion exchange resin like cholestyramin or colestipol to absorb the toxin of Clostridioides Difficile.

Cholestyramin is not taken simultaneously with Metronidazole, because Metronidazole is linked to cholestyramin and is inactive. Clindamycin cannot be effectively removed from the blood.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using nakai drugs , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Digestive: Nausea, vomiting, diarrhea due to Clostridioides Difficile.

Uncommon, 1/1000

Skin: urticaria.

Response response after intramuscular injection, intravenous inflammation after intravenous injection.

Rare, 1/10000

Anaphylaxis .

Blood: Eosin hypernagus, neutropenia recovery. digestive: fake colitis, esophagitis. liver: Increased liver transaminase recovery.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

contraindicated

Nakai drug contraindicated in the following cases:

Patients with clickamycin.

Be cautious when using

Caution when taking drugs in people with gastrointestinal diseases or a history of colitis, elderly patients with special sensitivity to drugs.

Clindamycin accumulates in serious liver failure patients, so the dose adjustments and periodic analysis of liver enzyme must be adjusted for these patients.

To be out of reach of children.

The ability to drive and operate machinery

This drug has no impact on the ability to drive and operate machinery.

Pregnancy

only use clindamycin when really necessary.

breastfeeding period

clindamycin excreted into breast milk (about 0.7–3.8 micrograms/ml), so should avoid breastfeeding during drug treatment.

Drug interaction

Clindamycin can increase the effects of neurotransmitters, so it should be used very carefully when the patient is taking these drugs. Clindamycin should not be used simultaneously with the following drugs:

Oral contraceptive oral contraceptives, as reducing the effects of these drugs.

erythromycin, because these drugs are acting in the same position on bacterial ribosome, so the link of this drug with ribosome bacteria can inhibit the effect of the other drug.

diphenoxylate, loopamide or opiate (anti -peristalt substances), these drugs can worsen colitis syndrome due to clindamycin, as they slow down toxins.
Kaolin -Pectin chaos, because of reducing clindamycin absorption.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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