NALGIDON-400 Synmedic tablets for menstruation, headache, toothache (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Dexibuprofen

Ingredient

Composition information	Content
Dexibuprofen	400mg

Uses

Indications

NALGIDOL 400 drug are indicated in the following cases:

Analgesic and anti -inflammatory from mild to moderate in some diseases such as Sutta (have good and safe effects), headache, toothache and teeth, musculoskeletal pain. Learning

dexibuprofen is the right rotating isomer (s (+)-ibuprofen) with pharmacological activity of ibuprofen racemic (is the equal mixture of 2 isomers R (-) and S (+)-ibuprofen). Dexibuprofen has a stronger pharmacological effect than ibuprofen. Dexibuprofen is used to relieve pain and anti -inflammatory level from mild to moderate.

Like other nonsteroidal anti -inflammatory drugs, dexibuprofen has analgesic, fever and anti -inflammatory effect. The mechanism of action of the drug is Prostaglandin Synthetase inhibitors, thus preventing prostaglandin, thromboxane and other products of cyclooxygenase. Dexibuprofen also inhibits prostaglandin synthesis in the kidneys, which can cause the risk of water stasis due to reducing blood flow to the kidneys.

Need to pay attention to this for patients with kidney failure, heart failure, liver failure and disorders with plasma volume disorders. The anti -inflammatory effect of Dexibuprofen appears after 2 days of treatment. Dexibuprofen has a stronger antipyretic effect than aspirin, but inferior to indomethacin. The drug has good anti -inflammatory effects and has good analgesic effect in the treatment of rheumatoid arthritis.

pharmacokinetic

absorption

Dexibuprofen absorbs mainly in the small intestine. The maximum concentration of the drug in plasma is achieved after 1–2 hours. Take the medicine and food that slowly reach the maximum concentration (2.1 hours after taking the drug at a hunger and 2.8 hours after drinking, the drug is full) and reduces the maximum concentration in plasma from 20.6 μg to 18.1 μg but does not affect the total amount of drugs absorbed.

Distribution

The drug is highly attached to plasma proteins (about 99%).

Metabolism - except for

After the metabolism in the liver, the metabolites are not fully eliminated, mainly through the kidneys (90%), and partly through the bile. The waste sale time of dexibuprofen is 1.8–3.5 hours. Dexibuprofen eliminates very quickly through the urine (1% in constant form, 14% in the form of combined).

Before taking NALGIDON-400 Synmedic tablets for menstruation, headache, toothache (3 blisters x 10 tablets)

How to use

Oral drugs.

Dosage

Adults: Ordinary dose for pain to reduce pain: 600 - 900 mg/day, divided into 2-3 times. The maximum dose of 1 time is 400 mg. The dose may increase unexpectedly up to 1200 mg/day, in case of severe acute pain.

Children: Dexibuprofen is not used for children under 18 years old because of the safety of this age has not been confirmed.

Elderly: Using the lowest dose has the effect. The dose may increase if tolerated well.

People with mild and medium liver failure or mild to moderate renal failure: Start with low doses and need closely monitoring. Do not use for severe liver failure or severe kidney failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

often treat symptoms and support. If you have overdose, you need to apply the following measures to increase elimination and inactivity: gastric lavage, vomiting and diuretic, drinking activated carbon or salt bleach.

If severe: hemorrhage or blood transfusion. Because the drug causes acidosis and elimination in the urine, theoretically will benefit when transmitting alkaline and diuretic.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using nalgidol 400 , you may experience unwanted effects (ADR).

Common, ADR> 1/100

Abdominal distention, nausea, vomiting, abdominal pain, diarrhea, fever, fatigue, headache, dizziness, dizziness.

Uncommon, 1/1000

Allergic reactions (especially bronchospasm in patients with asthma), rhinitis, urticaria, rashes, foreign rash, drowsiness, insomnia, tinnitus, stomach bleeding, progressive stomach ulcers, constipation, prolonged bleeding time.

Rare, ADR

Constipation , peripheral edema, rash, Stevens - Johnson syndrome, hair loss, leukopenia, platelets, neutropenia, eosinophilia, Eosin, granulocytes, anemia, abnormal liver function testing tests, acute liver toxicity, interstitial renal disease, kidney syndrome.

Instructions on how to handle ADR

If the patient looks blurred, reduced vision, or colorful color disorders, stop using dexibuprofen. If there is a mild digestive disorder, you should take medicine when eating or drinking with milk.

When encountering other side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

NALGIDOL 400 contraindicated in the following cases:

Hypersensitivity to Dexibuprofen or any ingredients of the drug.

Hypersensitivity to aspirin or other nonsteroidal anti -inflammatory drugs (asthma, rhinitis, urticaria after taking aspirin).

Progressive peptic ulcer , people with Crohn disease or progressive colon ulcer.

Patients with asthma or bronchospasm, bleeding disorders, cardiovascular disease, a history of peptic ulcer, liver failure or kidney failure (glomerular filtration flow below 30 ml/min). Patients are being treated with anticoagulants.

Patients with congestive heart failure, reduced circulatory mass due to diuretics or renal failure (increased risk of kidney dysfunction), severe liver failure.

Patients with glue (at risk of aseptic meningitis. It should be noted that all patients with aseptic meningitis have a history of an autoimmune disease).

The last three months of pregnancy.

Caution when using

Caution for patients tends to suffer unwanted effects on gastrointestinal tract when using nonsteroidal anti -inflammatory drugs (such as Dexibuprofen), including those who are suffering from digestive disorders , previous people with stomach ulcers, duoden, colon, addictive, addictive, addictive, addictive, addictive, alcoholic ulcer. Need close monitoring, especially gastrointestinal bleeding.

Be careful when using dexibuprofen for people with heart failure, hypertension, liver or kidney disease, especially those who are treating diuretics, because there is a risk of water retention or adversely affecting kidney function, if needed to use dexibuprofen for these patients, they need to use the lowest doses possible and periodically test kidney function. Be cautious when using Dexibuprofen for the elderly because this age tends to suffer from unwanted effects with non -steroid anti -inflammatory drugs higher than young people.

The ability to drive and operate machinery

The drug can cause dizziness and fatigue, so be careful when doing jobs that require alertness like driving or operating machine.

Pregnancy

Anti -inflammatory drugs that can inhibit uterine contractions and slow down. Non -steroid anti -inflammatory drugs may also increase severe lung pressure and severe respiratory failure in infants due to early closing of the ductus arterioscleria. These drugs also inhibit platelet function, increasing the risk of bleeding.

After taking nonsteroidal anti -inflammatory drugs, there is also a risk of less amniotic fluid and anuria in babies. In the last 3 months of pregnancy, it must be very limited to use for any anti -inflammatory drugs. These drugs also have absolute contraindications in a few days before birth.

Breastfeeding period

Dexibuprofen into breast milk is very little, negligible. Less risk for children at normal doses with mothers.

Drug interaction

Anticoagulants: may increase the risk of bleeding. If the treatment is simultaneously inevitable, it is necessary to monitor the bleeding time during the treatment period and if the dose is needed for anticoagulant drugs.

methotrexate at a dose of 15 mg/week or more: Dexibuprofen increases the toxicity of methotrexate. Therefore, patients who are being treated with high doses of methotrexate must not use Dexibuprofen.

For other nonsteroidal anti -inflammatory drugs: increased the risk of bleeding and ulcers.

Lithium: Non -steroid anti -inflammatory drugs may increase lithium concentration in plasma because of reducing lithium clearance in the kidney, thus avoiding these two drugs simultaneously. If the treatment is simultaneously inevitable, it is necessary to periodically check the lithium concentration, if the lithium dose is needed.

Storage

Store in a dry place, avoid light, temperature below 30 ° C.

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