Natidof 8 SPM tablets treat spondylosis, crooked neck, back pain (3 blisters x 10 tablets)

Dosage form Box of 3 blisters x 10 tablets
Specifications Excipients just enough, thiocolchicoside

Ingredient

Composition information	Content
August excipients just enough
Thiocolchicoside	8mg

Uses

indications

Natidof 8mg drugs are indicated for treatment fields to support painful spasms:

Degenerative spondylosis and spinal posture disorders: neck scoliosis, back pain, back pain. Excerpt from the "Colchique" tree. In vitro Thiocolchicoside is only linked to Gaba-A and sensitive Glycine receptors Strychnine.

thiocolchicoside acts as a GABA-A receptor antagonist, its muscle relaxation effect can be in a position on the spine, through the complex regulating mechanism, although the Glycinergic activity mechanism cannot be excluded.

Interactive characteristics of Thiocolchicoside with GABA-A receptors of qualitative and quantitative are shared by its main circulating metabolites, which lead to glucuronicization.

in vivo, the muscle relaxation properties of thiocolchicoside and the main metabolites show the different predictable models in rats and rabbits.

The lack of muscle relaxation effect of thiocolchicoside in rats with spine lesions shows the effect on the spine clearly of this compound. Thiocochicoside is also found to have anti -inflammatory and analgesic effects in some experiments after use, subcutaneous injection, intramuscularly and peritoneal injection.

Moreover, EEG pharmaceutical studies, thiocolchicoside and its main metabolites show that there is no sedative effect.

pharmacokinetics

absorption:

The muscle relaxation effect of thiocolchicoside appears average within 1-2 hours after drinking. Birth is 25% for oral.

Average peak concentration in plasma is 4.5 hours and is noted that there is no accumulation after the dose of 8 mg/day is repeated within 7 days.

Metabolism:

thiocolchicoside is metabolized in plasma. Thiocolchicoside is converted into 3 main substances.

Two types of circulating are thiocolchicoside aglycon and glucuronic derivatives of thiocolchicoside, they are active substances.

Era:

The average of the excreted exam in the urine is 8% when using a single dose. Large quantities of thiocolchicoside are eliminated through feces.

Before taking Natidof 8 SPM tablets treat spondylosis, crooked neck, back pain (3 blisters x 10 tablets)

How to use

Natidof 8mg oral drugs.

Dosage

Medicines for adults:

Initial dose 16 mg/day.

acute form: can be increased from half a dose every 2 days to double the starting dose, or the exception tripled (short -term treatment).

Prepare for motor therapy: Note the necessary time (1-2 hours) for the drug to work.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

When using Natidof 8mg you may experience unwanted effects (ADR).

Common, ADR> 1/100

Skin: Perhaps on the skin.

rare, ADR

Digestive: digestive disorders, diarrhea, stomach pain.

Instructions on how to handle ADR

When experiencing side effects of the drug, it is necessary to stop using and notify the doctor or go to the nearest medical facility for timely treatment.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Natidof drug 8mg contraindicated in the following cases:

Hypersensitivity to Thiocolchicoside or any ingredients of the drug.

Be cautious when using

reduce the dose when necessary if diarrhea appears after overdose.

The ability to drive and operate machinery

Although this drug is rarely causing drowsiness, this ability must be noted.

Pregnancy

Animal studies do not show that Thiocolchicoside has a teratogenic effect. Clinically, studies on pregnant women are limited, so it is impossible to conclude that taking drugs during pregnancy is completely harmless. Do not use for pregnant women because of the risk of genetics.

Breastfeeding period

Should not be used for women who are breastfeeding due to thiocolchicoside are excreted through milk.

Drug interaction

drug interactions may affect the activity of the drug or cause side effects. Should notify the doctor or pharmacist a list of drugs and functional foods you are using. Do not use or increase or decrease the dose of the drug without the guidance of a doctor.

Storage

In a dry place, avoid light, the temperature does not exceed 30 ° C.

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