Natrofen Cefprozil 500mg Remedina Treatment of respiratory infections, skin infections (3 blisters x 4 tablets)

Dosage form Box of 3 blisters x 4 tablets
Specifications Cefprozil

Ingredient

Composition information	Content
Cefprozil	500mg

Uses

indications

Natrofen drugs are indicated in the following cases:

Indications for cases of infections caused by sensitive bacteria in the following diseases:

Upper respiratory tract infections: pharyngitis, tonsillitis, acute sinusitis and acute otitis media Calculate ...

Need to conduct research on the quantity as well as the sensitivity of bacteria, if possible, should determine the level of sensitivity of pathogens whether or not produces penicillinase and sensitive strains of Staphylococus Pyogenes.

Pharmacological

cefprozil is a semi -oral synthetic antibiotic in the cephalosporin group. Cefprozil is a second -generation antibiotic, like other cephalosporin drugs. Cefprozil works by the mechanism of inhibiting peptidoglican biosynthesis, thereby inhibiting the synthesis of bacterial cell walls.

Cefprozil works on gram (+) bacteria, gram (-) bacteria and a few anaerobic bacteria, the effect of Cefprozil is presented below:

bacteria gram (+):

Staphylococci: Staphylococcus aureaus (only acting on the strain is sensitive to methicillin, Natrofen does not work on staphylococcusures resistant to methicilin). Staphylococcus epidermidis, Staphylococcus Warneri.

Streptococci: Streptococcus pyogenes (strepcococci group A). Streptococcus Agalactiae (Streptococci Group B). Streptococcus pneumonia, Streptococci group C, D, F and G ...

bacteria gram (-):

Moraxella (Branhamella) CatVrhalis, Haemophilus Influenza (including they can synthesize Beta-Lactamase enzymes), Citrobacter Diverus, Eschelia Coli Klebsiella Pneumoniae. Neisseria gonorrhoeae (including they have the ability to synthesize penicillinase), Proteus Mirabilis, Salmonella spp., Shigella spp., Vibrio spp.

For bacterial infections caused by Citrobacter Diversus and Klebsiella Pneumonia, before conducting treatment, it is necessary to check the sensitivity of bacteria to the drug. Natrofen has almost no effect on Acinetobacter spps., Entobacter spp

Anaerobic bacteria:

Prevotella Melaninogenicus (most strains belonging to Bacteroides Fragilis have resisted Natrofen resistance), Clostridium difficile. Clostridium Perfrigens. Fusobacterium spp., Peptostreptococcus spp., Proionibacterium acnes.

Dynamic pharmacokinetics

Cefprozil absorbs well through the gastrointestinal tract, oral bioavailability of Cefprozil at about 90%, the drug reaches the peak concentration in plasma within 1.5 hours. Food does not affect the absorption and concentration of the drug in the blood, but lasts the time to reach the peak concentration in plasma from 15 - 45 minutes.

Cefprozil is linked to plasma proteins at 36%, and does not depend on the dose ranging from 2 mcg/ml to 20 mcg/ml. The average disposal time under normal conditions is 1.3 hours. No evidence of drug accumulation in people with normal kidney function when taking a dose of 1 g every 8 hours in 10 days. Cefprozil excreted milk with a very small amount (less than 0.3% dose).

The drug is excreted mainly in urine, about 60% of the drug is eliminated in the original form through the urine within 24 hours. In the first 4 hours when taking the drug at a dose of 500 mg, the average concentration of the drug in sub -urine is approximately 450 mcg/ml.

In patients with renal failure, the sale time of the drug is prolonged and can be up to 5.2 hours, in patients who have completely lost the kidney function, the average selling time of Cefprozil is about 5.9 hours, in case of artificial dialysis, this time is shortened to 2.1 hours.

In patients with impaired liver function, pharmacokinetic parameters are not different for normal people.

Pharmacokinetics on the elderly: After getting Cefprozil 1 g a single dose. The average AUC observed in healthy elderly people is about 35-60% higher than normal people, and in women higher than men is about 15-20%.

Children from 6 months to 12 years old, the drug reaches a maximum concentration in plasma after 1-2 hours of using the drug, and the sale time is about 1.5 hours. When using Cefprozil for children with a single dose of 15 mg/kg, AUC is equivalent to the dose of 500 mg in adults.

Before taking Natrofen Cefprozil 500mg Remedina Treatment of respiratory infections, skin infections (3 blisters x 4 tablets)

How to use

oral tablets before/during or after meals. Take the tablet with a glass of water.

Dosage

Cefprozil's recommended dose for specific objects and infections are presented in detail in the table below:

Objects/types of infections Dosage (Mg) Now 10 DA

upper respiratory infections

Skin infections and uncomplicated skin structures 20 mg/kg every 24 hours 10

Now 10

* Do not exceed the recommended dose for adults.

Note: For doses of less than 500 mg/time, this product is inappropriate, please refer to the use of appropriate dosage or dosage.

kidney failure

Cefprozil can be indicated for patients with impaired renal function. Dosage and duration of medicine will be adjusted based on the patient's creatinine clearance according to the table below:

Creatinine clearance (ml/minute) Dosage (Mg) Time to bring drugs 29* ½ dose unchanged

liver failure

No need to adjust the dose for patients with liver function impairment.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.What do

do when using overdose? Single dose 3000 mg/kg oral causing diarrhea and appetite in Cynomolgus but not fatal.

cefprozil excreted mainly through the kidneys. In case of overdose, especially in patients with impaired renal function, hemolytic jasmine will help remove Cefprozil from the body.

In case of emergency, call the 115 emergency center immediately or go to the nearest local health station.

What to do when you forget 1 dose? However, if the time to relax with the next dose is too short, skip the dose and continue the calendar of the drug. Do not use double doses to compensate for missed dose.

Side Effects

When using the drug, there are common unwanted effects (ADR):

The unwanted effect of Cefprozil is similar to other oral cephalosporins. In general, the drug is well tolerated, about 2% of patients have to stop using Cefprozil due to adverse effects.

The most common adverse effects observed in patients treated with Cefprozil are listed below:

Digestive: diarrhea (2.9%), nausea (3.5%), vomiting (1%) and abdominal pain (1%). Like other penicillin and other cephalosporin antibiotics, the cholestatic jaundice is also reported at a rare rate. These reactions are reported more often in children than adults. These signs and symptoms usually appear a few days after the beginning of treatment and decrease within a few days after the end of treatment. All these adverse effects can recover. Sex and vaginitis (1.6%).

Attention for the cephalosporin group

In addition to the unwanted effects listed above, the undesirable or changing effects in the following test results are reported to antibiotics of cephalosporin groups:

Anemia, hemolytic anemia, hemorrhagic, renal dysfunction, poisoned epidermal necrosis, prolonged prothrombin time, fake positive test coombs, increased LDH, reduced all bloody globe, neutropenia, granulocytosis.

A few cephalosporin antibiotics are given seizures, especially in patients with renal impairment, when the dose is not reduced. If the seizure appears related to the drug, stop using the drug. Anti -seizure drugs can be used if clinical indications.

Instructions on how to handle ADR:

Notify the physician with unwanted effects when using the drug.

Warnings

Before using the drug you need to read the instructions carefully and refer to the information below.

Contraindicated

Contraindicated Natrofen in the following cases:

Hypersensitivity to cefprozil, cephalosporin antibiotics or any ingredients of the drug.

Caution when using

Warning

Before indicating treatment with Natrofen, it is necessary to consider the patient with a history of hypersensitivity to cefprozil, cephalosporin, penicillin, or other drugs. If the patient has a history of hypersensitivity to penicillin, a cross -allergic reaction may appear with Natrofen.

If the hypersensory reaction appears to Natrofen, stop using the drug and immediately notify the treating doctor. In the case of acute serious hypersensitivity reactions, other emergency therapies may be appointed (epinephrin, other emergency measures including oxygen breathing, infusion, antihistamine, corticosteroids, ...).

Antibiotic treatment can cause diarrhea. In that case, it is necessary to notify the doctor and receive the corresponding treatment measures.

Notify the treating doctor if there is a history of gastrointestinal disease, especially colitis.

The safety and effectiveness of Cefprozil has not been established in children under 6 months of age in the treatment of otitis media and acute sinusitis, on children under 2 years of age in the treatment of pharyngitis sore throat or skin infections and uncomplicated skin structure. However, there has been a report on the accumulation of other cephalosporin antibiotics on newborns (the result of extending the sale time of the drug in this age group).

There have been reports on positive condition when directly testing Coombs in patients treated with cephalosporin antibiotics.

Precautions

Need to be very cautious when taking drugs for patients in the following cases:

Caution for patients with renal impairment: It is necessary to assess the kidney function of the patient before prescribing the drug, and monitor the kidney function during the treatment process, and adjust the dose when necessary. appropriate management.

The effect of the drug on the ability to drive and operate machinery

dizziness, headache, stress, confusion and chicken sleep have been reported during Cefprozil treatment, and can affect driving and operating machinery. Therefore, not driving and operating machinery if encountered the adverse effects on using Cefprozil.

Use drugs for women during pregnancy and lactation

Pregnancy

Reproductive influence studies have been conducted on rabbits, rats and rats with Cefprozil oral doses at 0.8, 8.5 and 18.5 times compared to the maximum recommended dose in humans (100 mg/day), calculated by Mg/M and not detect harmful effects on the fetus. However, there is not enough data on detailed detailed studies on pregnant women.

Because animal reproductive studies are not always possible to accurately predict the response on humans, therefore, only this medication during pregnancy is really necessary.

Cefprozil has not been studied during labor and childbirth. Only use the drug when really necessary.

Breastfeeding period

Small amount of Cefprozil (

Drug interaction

simultaneous use of cephalosporin and aminoglycosides increases the toxicity of the kidneys.

Concomitance use of cephalosporin and probenecids doubled the area under the AUC curve of Cefprozil.

In laboratory interactive studies: Cephalosporin antibiotics can cause false positive reactions in some urine tests according to the principle of reducing copper, this phenomenon does not occur with tests based on enzymes. There may be false negative reactions for test ferricyanid to check blood sugar.

The presence of Cefprozil in the blood does not affect the creatinine tests in the blood and urine by alkaline picrat.

Storage

Leave a cool place, avoid light, temperatures below 30⁰C.

To be out of reach of children, read the instructions carefully before use.

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