Naupastad 10 Stella tablets treat symptoms of vomiting and nausea (10 blisters x 10 tablets)

Dosage form Box of 10 blisters x 10 tablets
Specifications Domperidone

Ingredient

Composition information	Content
Domperidone	10mg

Uses

Indications

naupastad 10 is indicated to treat symptoms of vomiting and nausea.

Pharmacokology

Pharmacological group: Drugs to treat stomach dysfunction; The drug promotes stomach peristalsis.

domperidone is a dopamine resistant with anti -vomiting properties. In people using domperidone, especially adults, unwanted effects as the surgeon syndrome is rare, but domperidone promotes prolactin secretion in the pituitary gland.

Anti -vomiting effects may be due to peripheral coordination (gastric movement) and dopamine receptor resistance in CTZ chemical sensor area located outside the brain blood barrier in the postrema area.

Human studies show that the use of oral domeridone increases the pressure of the lower esophageal pressure, improves the permanent peristalsis and increases the empty process of the stomach. The drug does not affect the excretion of the stomach.

pharmacokinetic

Despite the rapid absorption, bioavailability of the domeridone's body only reaches about 15% in hungry people who drink single dose, and increase when using domperidone after meals. Low bioavailability due to drugs is metabolized through the liver for the first time and metabolism in the intestine.

more than 90% of domperidone is connected to plasma proteins and has a final waste time of 7.5 hours. Fast metabolism and many liver. The main metabolic path is reducing the Alkyl root at N's position thanks to the isenzyme CYP3A4 of Cytochrom P450 and the aromatic hydroxylation hydroxyl thanks to CYP3A4, CYP1A2 and CYP2E1.

About 30% of oral doses are excreted in urine within 24 hours, most of them in the form of metabolites; The rest is eliminated through feces after a few days and about 10% in intact form. Medicines are difficult to pass the brain barrier.

Small amount of domeridone is distributed into breast milk, the concentration reaches 10-50% in the mother's serum.

Before taking Naupastad 10 Stella tablets treat symptoms of vomiting and nausea (10 blisters x 10 tablets)

How to use

Naupastad 10 should only be used at the lowest doses that are effective in the shortest time to control vomiting and nausea.

Should drink Naupastad 10 before meals. If taken after meals, the drug may be slowly absorbed.

Patients should take medicine at a fixed time. If you forget a dose, you can skip the dose and continue taking the drug according to the same schedule. Do not double the dose to compensate for the forgotten dose.

Maximum treatment time should not exceed a week.

Dosage

Adults and adolescents (aged 12 and older and weighing 35 kg or more): Can be used up to 10 mg 3 times/day, a maximum dose of 30 mg/day.

Patients with liver failure: Naupastad 10 is contraindicated to patients with average and severe liver failure. No need to adjust the dose for patients with mild liver failure.

Patients with kidney failure: Due to the prolonged semi -waste time of the domeridone in patients with severe renal impairment, if used repeated, the number of Naupastad 10 use should be reduced to 1-2 times/day and adjust the dose depending on the degree of renal failure.

Note: The above dose is for reference only. Specific dosage depends on the condition and level of progression of the disease. For a suitable dose, you need to consult a doctor or medical specialist.

What to do when overdose?

Symptoms

Symptoms of overdose include chicken sleep, loss of orientation and foreign reactions, especially in children.

Handling

There is no specific antidote for domperidone, but in case of overdose, gastric lavage as well as use of activated carbon may be useful. Strict medical monitoring and supportive treatment. Anti -anti -cholinergic drugs, Parkinson's treatments can be helpful in controlling foreign reactions. Should monitor the electrocardiogram because it is likely to extend QT.

What to do when you forget a dose? However, if close to the next dose, skip the forgotten dose and take the next dose at the time as planned. Note that it should not be used double the prescribed dose.

Side Effects

Unwanted effects (ADR) when using Naupastad 10 mg that you may encounter:

Uncommon: Breast pain. Eye of eye; Reduce libido; ventricular arrhythmia, extending the QTC, twisted, sudden death due to cardiovascular. Periodic dysfunction in infants and children

Warnings

Contraindicated

Naupastad 10 mg is contraindicated in the following cases:

Hypersensitivity to any ingredients of the drug.

Panisons with pituitary tumors cause prolactin secretion (prolactinoma).

Cases of stimulating stomach peristalsis can be dangerous for example, patients with gastrointestinal bleeding, mechanical bowel obstruction or puncture of the digestive tract.

Patients with average or severe liver failure.

Patients with prolonged heart impulse transmission time, especially about QTC, patients with clear electrolytes or patients with cardiovascular disease such as congestive heart failure.

Simultaneous use of the drugs extending the QT.

Concentric use of CYP3A4 inhibitors (regardless of the effect of extension of QT).

Precautions when used

Renal failure: Domperidone's waste time is prolonged in patients with severe renal impairment. In the case of repeated use, the frequency of using domperidone should be reduced to 1-2 times/day depending on the level of renal failure. Can adjust the dose if needed.

Cardiovascular:

domperidone extends the QT distance on the electrocardiogram. In the process of post -commerce monitoring, there are very few reports on the QT interval and the top torsion related to the use of domperidone. These reports have risk factors such as electrolyte disorders or simultaneous medications.

Epidemiological studies show that domperidone may increase the risk of severe ventricular arrhythmia or sudden cardiovascular disease. This risk is higher for patients over 60 years old, patients taking daily doses greater than 30 mg and patients with simultaneous use of the drug extending the QT or CYP3A4 inhibitors.

Use domperidone with the lowest doses effectively in adults and children.

Contraindicated for patients with prolonged heart impulse transmission time, especially about QTC, patients with significant electrolyte disorders (hypotension, hyperkalemia, hypoglycemia), blood rhythm or cardiovascular patients with cardiovascular disease such as serious heart failure due to the risk of ventricular disorders. Electrolyte disorders (hypotension, hyperkalemia, hypoglycemia) or slow heart rate have been known as a factor that increases the risk of arrhythmia.

Need to stop treatment with domperidone and exchange with health workers if there are any symptoms or signs related to arrhythmia.

Advise patients to quickly report symptoms on the heart.

Naupastad 10 contains lactose. This drug should not be used for patients with rare genetic problems galactose intolerance, total lactase enzyme deficiency or glucose - galactose.

The ability to drive and operate machinery

When using domperidone may occur from the foreign tower and drowsiness at a very low rate. If these unwanted effects, patients should not drive or operate machinery.

Pregnancy

unknown ability of drugs in humans. Therefore, domeridone should only be used during pregnancy when the benefits are proven.

Breastfeeding period

domperidone excreted through breast milk and breastfed babies receive less than 0.1% dose by mother's weight. Unwanted effects, especially the effect on the heart can still occur after breastfed babies. The benefits of breastfeeding and the benefits of mothers treat to decide to stop breastfeeding or stop/avoid domeridone treatment. Be careful in case of risk factors that extend QTC in breastfeeding.

Drug interaction

Increased risk of extending the QT distance due to pharmacokinetic interaction and/or pharmacodynamic.

Contraindicated with the following drugs:

The drug extends the range of QTC:

IA's anti -arrhyths (for example: disopyramid, hydroquinidin, quinidine).

Anti -arrhythmia group III (for example: Amiodaron, dofetilid, droneedaron, ibutilid, sotalol).

Some anti -psychotic drugs (for example: Haloperidol, Pimozid, Servindol).

Some antidepressants (e.g. citalopram, Escitalopram).

Some antibiotics (for example: erythromycin, levofloxacin, moxifloxacin, spiramycin).

Some antifungal drugs (for example, pentamidin).

Some medications for malaria treatment (especially halofantrin, lumefantrin).

Some gastric - intestinal drugs (for example: Cisaprid, Dolasetron, Prucaloprid).

Some antihistamine drugs (for example: Mequitazin, Mizolastin).

Some cancer treatments (for example: Toremifen, Vandetanib, Vincamin).

Some other drugs (for example: Bepridil, Diphemanil, Methadon).

Strong CYP3A4 inhibitors (regardless of the effect of extending QT), for example:

Protease inhibitors.

Azol body antifungal drugs.

Some macrolid drugs (erythromycin, clarithromycin and telithromycin).

It is not recommended to simultaneously use the following drugs

Average CYP3A4 inhibitors, for example: diltiazem, verapamil and some macrolid drug groups.

Use cautiously when used simultaneously with the following drugs:

Heart rate slow, medications that reduce potassium potassium and some macrolid drugs after contributing to extending the QT interval: azithromycin and Roxithromycin.

Storage

Store in closed packaging, dry place. The temperature does not exceed 300C.

Other drugs

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